Growth hormone releasing hormone

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Growth hormone releasing hormone
Identifiers
SymbolGHRH
Alt. symbolsGRF, GHRF
Entrez2691
HUGO4265
OMIM139190
RefSeqNM_021081
UniProtP01286
Other data
LocusChr. 20 p12 or q11.2-q12

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753


Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. [1]

Relationship of GRH & somatostatin

The actions of GHRH are opposed by "growth-hormone-inhibiting hormone"

Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary where it inhibits GH secretion. Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH. However recently it had been discovered that somatostatin does not affect the secretion of GH

Sequence

The amino acid sequence of GHRH is:

Tyr - Ala - Asp - Ala - Ile - Phe - Thr - Asn - Ser - Tyr - Arg - Lys - Val - Leu - Gly - Glu - Leu - Ser - Ala - Arg - Lys - Leu - Leu - Gln - Asp - Ile - Met - Ser - Arg - Glu - Gln - Gly - Glu - Ser - Asn - Gln - Glu - Arg - Gly - Ala - Arg - Ala - Arg - LeuNH2

References

  1. Obál F, Krueger J (2001). "The somatotropic axis and sleep". Rev Neurol (Paris). 157 (11 Pt 2): S12–5. PMID 11924022.


bg:Соматотропин-освобождаващ хормон de:Somatoliberin mk:Соматотропен ослободувачки хормон


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