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Slow-wave sleep (SWS) is made up of the two deepest stages of non-rapid eye movement sleep.
SWS is often referred to as deep sleep. The highest arousal thresholds (e.g. difficulty of awakening, such as by a sound of a particular volume) are observed in Stages 4 and 3, respectively. One will typically feel more groggy when awoken from these stages, and indeed, cognitive tests administered after awakening from stages 3-4 indicate that mental performance is somewhat impaired for periods up to 30 minutes or so, relative to awakenings from other stages. This phenomenon has been called "sleep inertia." If deprived of sleep, there is a sharp rebound of SWS, suggesting there is more of a "need" for this stage relative to the other stages. The major factor determining how much slow wave sleep is observed in a given sleep period is the duration of preceding wakefulness, likely related to accumulation of sleep-promoting substances in the brain. Some of the few endogenous factors known to increase slow-wave sleep in the sleep period that follows them include body heating (as by immersion in a hot tub), high carbohydrate ingestion, and intense prolonged exercise. The latter probably exerts its influence by increasing body temperature, and may delay sleep onset when occurring proximal to sleep.
In addition to these factors, the duration of SWS periods can be increased by ingestion of alcohol, THC, SSRIs, and other drugs. In instances such as these, TST (Total Sleep Time) is often unaffected due to circadian rhythms and/or a person's alarm clock and early morning obligations. This increase of SWS can lead to increased REM latency and a decrease in REM period durations. If the total time spent in REM is decreased long enough and repeatedly over a substantial amount of nights a "REM rebound" will occur in response to removal of its inhibitor. An increase in REM is believed to produce symptoms of depression and bipolar disorder in many patients for an amount of time relative to the severity of the previous "REM suppression". It is debatable whether or not this could explain the return in symptoms of depression disorder after removal of SSRI medications.
Large 75 microvolt (.5 - 3 Hz) delta waves predominate the electroencephalogram (EEG). Stage 3 is defined by Rechtschaffen and Kales as the point where delta waves make up 20-50% of a 30 second EEG epoch (generally 8-13 delta waves). Stage four is defined as a 30 second epoch that consists of greater than 50% delta waves (usually 14 or more delta waves per 30 second epoch).
Longer periods of slow wave sleep occur in the first part of the night, primarily in the first two sleep cycles (roughly 3 hours). Children and young adults will have more total slow wave sleep in a night than older adults. The elderly may not go into slow wave sleep at all during many nights of sleep.
The slow wave seen in the cortical EEG is generated through thalamocortical communication through the thalamocortical neurones. In the TC neurones this is generated by the 'slow oscillation' and is dependent on membrane potential bistability, a property of these neurones due to an electrophysiological component known as I t Window. I t Window is due to the overlap underneath activation/inactivation curves if plotted for T-type calcium channels (inward current). If these two curves are multiplied, and another line superimposed on the graph to show a small Ik leak current (outward), then the interplay between these inward (It Window) and outward (small Ik leak), three equilibrium points are seen at -90, -70 and -60mv, -90 and -60 being stable and -70 unstable. This property allows the generation of slow waves due to an oscillation between two stable points. It is important to note that in vitro, mGluR must be activated on these neurones to allow a small Ik Leak, as seen in vivo situations.
- Rechtschaffen, A (1968). A Manual of Standardized Terminology, Techniques and Scoring System For Sleep Stages of Human Subjects. US Dept of Health, Education, and Welfare; National Institutes of Health. Unknown parameter