Aromatic L-amino acid decarboxylase

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DOPA decarboxylase dimer 1JS3.png
Ribbon diagram of a domestic pig DOPA decarboxylase dimer. From PDB 1JS3.
DOPA decarboxylase (aromatic L-amino acid decarboxylase)
Identifiers
Symbol DDC
Entrez 1644
HUGO 2719
OMIM 107930
RefSeq NM_000790
UniProt P20711
Other data
EC number 4.1.1.28
Locus Chr. 7 p11

Aromatic L-amino acid decarboxylase (EC 4.1.1.28, synonyms: DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) is a lyase enzyme.

Reactions

It catalyzes several different decarboxylation reactions:

The enzyme uses pyridoxal phosphate as a cofactor.

As a rate limiting step

In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AAAD is not the rate-limiting step of in either reaction. However, AAAD becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson's Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia).

AAAD is the rate-limiting enzyme in the formation of biogenic trace amines.

See also

External links



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