Paget's disease of the breast differential diagnosis: Difference between revisions
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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology | ||
|- | |- | ||
!Rash | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash | ||
!Nipple | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nipple Discharge | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Erythema | |||
!Erythema | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Single/ | ||
!Single/ | |||
Multiple | Multiple | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" | | ||
!Involved areas | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Involved areas | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mastalgia | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mastalgia | ||
!Breast Exam | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Breast Exam | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum IgE | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum IgE | ||
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! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Eczema]] | ! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Eczema]] | ||
|Benign | style="background:#F5F5F5;" text-align: center;" |Benign | ||
| align="center" style="background:#F5F5F5;" | | | align="center" style="background:#F5F5F5;" | | ||
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*[[Erythema]], [[Exudate|exudates]], [[papules]],[[vesicles]], scales and crusts | *[[Erythema]], [[Exudate|exudates]], [[papules]],[[vesicles]], scales and crusts | ||
* Infiltrated [[erythema]], [[prurigo]], scales and crusts | * Infiltrated [[erythema]], [[prurigo]], scales and crusts | ||
| | | align="center" style="background:#F5F5F5;" | | ||
| align="center" style="background:#F5F5F5;" | – | | align="center" style="background:#F5F5F5;" | – | ||
| align="center" style="background:#F5F5F5;" | Multiple | | align="center" style="background:#F5F5F5;" | Multiple | ||
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* Adults - facial involvement and skin flexures | * Adults - facial involvement and skin flexures | ||
| align="center" style="background:#F5F5F5;" | – | | align="center" style="background:#F5F5F5;" | – | ||
| | | align="center" style="background:#F5F5F5;" | | ||
| align="center" style="background:#F5F5F5;" | | | align="center" style="background:#F5F5F5;" | | ||
* Centrofacial pallor | * Centrofacial pallor |
Revision as of 16:27, 21 February 2019
Paget's disease of the breast Microchapters |
Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Paget's disease of the breast differential diagnosis On the Web |
American Roentgen Ray Society Images of Paget's disease of the breast differential diagnosis |
Paget's disease of the breast differential diagnosis in the news |
Blogs on Paget's disease of the breast differential diagnosis |
Directions to Hospitals Treating Paget's disease of the breast |
Risk calculators and risk factors for Paget's disease of the breast differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Paget's disease of the breast must be differentiated from atopic dermatitis, eczema, psoriasis, malignant melanoma, Bowen's disease, basal cell carcinoma, and pagetoid dyskeratosis.[1][2]
Differential Diagnosis
Paget’s disease of the breast must be differentiated from other benign and malignant processes of nipple-areola complex such as:[1][2]
- Atopic dermatitis
- Chronic contact dermatitis
- Lactiferous duct ectasia
- Chronic eczema
- Psoriasis
- Nipple duct adenoma
- Malignant melanoma
- Bowen’s disease
- Superficial basal cell carcinoma
- Pagetoid basal cell carcinoma
- Benign intraductal papilloma
- Pagetoid dyskeratosis
Category | Diseases | Benign or Malignant | Etiology | Clinical manifestations | Para-clinical findings | Gold Standard | Associated factors | ||||||||||
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Symptoms | Physical examination | ||||||||||||||||
Lab Findings | Histopathology | ||||||||||||||||
Rash | Nipple Discharge | Erythema | Single/
Multiple |
Involved areas | Mastalgia | Breast Exam | Other | Serum IgE | |||||||||
Eczema
style="background:#F5F5F5;" text-align: center;" |Benign |
|
Scalp, face, trunk, postauricular, diaper area and axilla | + | – | + |
|
Nl |
|
Risk factors include
Generalized seborrheic erythroderma in immunodeficient patients |
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Skin disorders | Atopic dermatitis | Benign |
|
– | Multiple | + |
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– |
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↑ |
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Allergic contact dermatitis[3] | Benign |
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Erythematous well-demarcated papules | – | May be multiple after 1-2 days of exposure | + | Surrounding the area in contact with the offending agent | + |
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Nl |
|
| |||||
Psoriasis | Benign |
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Well-circumscribed, pink papules and symmetrically distributed cutaneous plaques with silvery scales | + | Multiple | + |
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+ |
|
Nl |
|
Risk factors include
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Malignant melanoma | |||||||||||||||||
Bowen’s disease | |||||||||||||||||
Superficial basal cell carcinoma | |||||||||||||||||
Pagetoid basal cell carcinoma | |||||||||||||||||
Benign intraductal papilloma | |||||||||||||||||
Pagetoid dyskeratosis | |||||||||||||||||
Lactiferous duct ectasia | Benign |
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Nipple duct adenoma | |||||||||||||||||
Benign Toker cell hyperplasia | |||||||||||||||||
Breast abscess | Benign | + |
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Mondors disease | |||||||||||||||||
Mastitis |
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+ | ± |
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|
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Inflammatory Breast Cancer |
References
- ↑ 1.0 1.1 Gaspari, Eleonora; Ricci, Aurora; Liberto, Valeria; Scarano, Angela Lia; Fornari, Maria; Simonetti, Giovanni (2013). "An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/206235. ISSN 2090-6862.
- ↑ 2.0 2.1 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ Nosbaum A, Vocanson M, Rozieres A, Hennino A, Nicolas JF (2009). "Allergic and irritant contact dermatitis". Eur J Dermatol. 19 (4): 325–32. doi:10.1684/ejd.2009.0686. PMID 19447733.