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{{DiseaseDisorder infobox |
__NOTOC__
  Name        = Bronchitis |
  ICD10      = {{ICD10|J|20||j|20}}-{{ICD10|J|21||j|20}} |
  ICD9        = {{ICD9|490}}-{{ICD9|491}} |
  MeshID      = D001991 |
}}
{{Bronchitis}}
{{Bronchitis}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''<br>
{{CMG}}; {{AE}}{{MehdiP}}
<br>
{{SK}} Inflammation of bronchus
==Overview==
Bronchitis is an [[inflammation]] of the [[bronchus|bronchi]] (medium and large size airways).<ref name=CDCBronchitis> Bronchitis (Chest Cold) - Get Smart: Know When Antibiotics Work. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/getsmart/community/for-patients/common-illnesses/bronchitis.html Accessed on July 28, 2016 </ref> [[Acute bronchitis]] is a self-limiting disease usually caused by [[virus]]es or [[bacteria]]. [[Chronic bronchitis]] is a subtype of the [[chronic obstructive pulmonary disease]] (COPD), and it is defined as a chronic productive cough for at least three months in two consecutive years, after excluding other causes of chronic cough. The inflammatory response of the bronchial epithelium to infections or [[irritants]] that involve the medium and large-sized airways results in thickening of the bronchial and tracheal [[mucosa]]. Hallmark features of the pathophysiology of chronic bronchitis include [[hyperplasia]] and [[hypertrophy]] of the [[Goblet cell|goblet cells]] of the airway, resulting in an increased mucus secretion, which contributes to the airway obstruction. [[Microscope|Microscopically]], there is [[Infiltration (medical)|infiltration]] of the walls of the airway with [[Inflammation|inflammatory]] cells, particularly [[neutrophils]]. Inflammation is followed by scarring and remodeling that thickens the walls, resulting in narrowing of the small airway. Further progression leads to [[metaplasia]] and [[fibrosis]] of the lower airway. The consequence of these changes is a limitation of airflow.<ref name="pmid19494220">{{cite journal |vauthors=Cosio MG, Saetta M, Agusti A |title=Immunologic aspects of chronic obstructive pulmonary disease |journal=N. Engl. J. Med. |volume=360 |issue=23 |pages=2445–54 |year=2009 |pmid=19494220 |doi=10.1056/NEJMra0804752 |url=}}</ref><ref name=kc>Kumar P, Clark M (2005). ''Clinical Medicine'', 6ed. Elsevier Saunders. pp 900-901. ISBN 0702027634.</ref><ref name="pmid22029978">{{cite journal |vauthors=McDonough JE, Yuan R, Suzuki M, Seyednejad N, Elliott WM, Sanchez PG, Wright AC, Gefter WB, Litzky L, Coxson HO, Paré PD, Sin DD, Pierce RA, Woods JC, McWilliams AM, Mayo JR, Lam SC, Cooper JD, Hogg JC |title=Small-airway obstruction and emphysema in chronic obstructive pulmonary disease |journal=N. Engl. J. Med. |volume=365 |issue=17 |pages=1567–75 |year=2011 |pmid=22029978 |pmc=3238466 |doi=10.1056/NEJMoa1106955 |url=}}</ref> Acute bronchitis affects young children and old people. Its overall incidence is approximately 5% in the U.S. There is no racial or gender predilection for this disease.<ref name="pmid11209098">{{cite journal |vauthors=Macfarlane J, Holmes W, Gard P, Macfarlane R, Rose D, Weston V, Leinonen M, Saikku P, Myint S |title=Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community |journal=Thorax |volume=56 |issue=2 |pages=109–14 |year=2001 |pmid=11209098 |pmc=1746009 |doi= |url=}}</ref><ref name="pmid17108344">{{cite journal |vauthors=Wenzel RP, Fowler AA |title=Clinical practice. Acute bronchitis |journal=N. Engl. J. Med. |volume=355 |issue=20 |pages=2125–30 |year=2006 |pmid=17108344 |doi=10.1056/NEJMcp061493 |url=}}</ref><ref name=book1>Ferri FF. Ferri's Clinical Advisor 2016, 5 Books in 1. Elsevier Health Sciences; 2015.</ref>Although chronic bronchitis is common among geriatric patients, it occurs more commonly among caucasian individuals compared to other races, and there is no sexual predilection.<ref>[http://www.wrongdiagnosis.com/c/copd/prevalence.htm wrongdiagnosis.com > Prevalence and Incidence of COPD] Retrieved on Mars 14, 2010</ref>
Age, season of the year and the immunization status are the main determining risk factors for acquiring acute bronchitis.<ref name="pmid11119400">{{cite journal |vauthors=Gonzales R, Sande MA |title=Uncomplicated acute bronchitis |journal=Ann. Intern. Med. |volume=133 |issue=12 |pages=981–91 |year=2000 |pmid=11119400 |doi= |url=}}</ref><ref name="pmid17108344">{{cite journal |vauthors=Wenzel RP, Fowler AA |title=Clinical practice. Acute bronchitis |journal=N. Engl. J. Med. |volume=355 |issue=20 |pages=2125–30 |year=2006 |pmid=17108344 |doi=10.1056/NEJMcp061493 |url=}}</ref><ref name="pmid21121518">{{cite journal |vauthors=Albert RH |title=Diagnosis and treatment of acute bronchitis |journal=Am Fam Physician |volume=82 |issue=11 |pages=1345–50 |year=2010 |pmid=21121518 |doi= |url=}}</ref> The most potent risk factor in the development of [[chronic bronchitis]] is cigarette smoking.<ref name="medcauses">[http://www.medicinenet.com/chronic_obstructive_pulmonary_disease_copd/page3.htm7whatcauses MedicineNet.com - COPD causes]</ref> Other risk factors are occupational pollutants such as cadmium and silica, air pollutants, and genetic factors such as [[alpha 1 antitrypsin deficiency]]<ref>[http://www.nlm.nih.gov/medlineplus/ency/article/000091.htm MedlinePlus Medical Encyclopedia]</ref>
Acute bronchitis is a self limiting lower respiratory tract infection that usually presents with cough that lasts for up to 3 weeks.<ref name="pmid11119400">{{cite journal |vauthors=Gonzales R, Sande MA |title=Uncomplicated acute bronchitis |journal=Ann. Intern. Med. |volume=133 |issue=12 |pages=981–91 |year=2000 |pmid=11119400 |doi= |url=}}</ref><ref name="pmid16798599">{{cite journal |vauthors=Landau LI |title=Acute and chronic cough |journal=Paediatr Respir Rev |volume=7 Suppl 1 |issue= |pages=S64–7 |year=2006 |pmid=16798599 |doi=10.1016/j.prrv.2006.04.172 |url=}}</ref> Chronic bronchitis gradually worsens over time and can result in death. The rate of deterioration varies between individuals and depends on the level of airflow obstruction. The prognosis is dependent on early recognition and smoking cessation, which improves the outcome significantly. Smoking cessation, good hand hygiene, vaccination, and a reduction in occupational exposure to known risk factors, are important to ensure decreased severity and risk of bronchitis.<ref name="pmid21121518">{{cite journal |vauthors=Albert RH |title=Diagnosis and treatment of acute bronchitis |journal=Am Fam Physician |volume=82 |issue=11 |pages=1345–50 |year=2010 |pmid=21121518 |doi= |url=}}</ref><ref name="pmid16428698">{{cite journal |vauthors=Braman SS |title=Chronic cough due to acute bronchitis: ACCP evidence-based clinical practice guidelines |journal=Chest |volume=129 |issue=1 Suppl |pages=95S–103S |year=2006 |pmid=16428698 |doi=10.1378/chest.129.1_suppl.95S |url=}}</ref>
==Causes==
*<font size="3">'''[[Acute bronchitis|Acute Bronchitis]]:'''</font>  may be caused by either viruses, bacteria or environmental factors.
::'''Viruses:''' [[Influenza]] virus, [[parainfluenza virus]], [[respiratory syncytial virus]], [[coronavirus]], [[adenovirus]], [[enterovirus]], [[rhinovirus]], [[coxsackievirus]], and human [[metapneumovirus]]<ref name="pmid9323784">{{cite journal |vauthors=Jonsson JS, Sigurdsson JA, Kristinsson KG, Guthnadóttir M, Magnusson S |title=Acute bronchitis in adults. How close do we come to its aetiology in general practice? |journal=Scand J Prim Health Care |volume=15 |issue=3 |pages=156–60 |year=1997 |pmid=9323784 |doi= |url=}}</ref><ref name="pmid12402203">{{cite journal |vauthors=Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Côté S, Peret TC, Erdman DD, Anderson LJ |title=Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups |journal=J. Infect. Dis. |volume=186 |issue=9 |pages=1330–4 |year=2002 |pmid=12402203 |doi=10.1086/344319 |url=}}</ref><ref name="pmid16107980">{{cite journal |vauthors=Louie JK, Hacker JK, Gonzales R, Mark J, Maselli JH, Yagi S, Drew WL |title=Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season |journal=Clin. Infect. Dis. |volume=41 |issue=6 |pages=822–8 |year=2005 |pmid=16107980 |doi=10.1086/432800 |url=}}</ref>
::'''Bacteria:''' [[Mycoplasma pneumoniae|''Mycoplasma pneumoniae'']], [[Chlamydophila pneumoniae|''Chlamydophila pneumoniae'']], and ''[[Bordetella pertussis]]''<ref name="pmid17108344">{{cite journal |vauthors=Wenzel RP, Fowler AA |title=Clinical practice. Acute bronchitis |journal=N. Engl. J. Med. |volume=355 |issue=20 |pages=2125–30 |year=2006 |pmid=17108344 |doi=10.1056/NEJMcp061493 |url=}}</ref>
::'''Environmental factors:''' Toxic fume inhalation, tobacco, dust, and aerosols<ref name="pmid11106722">{{cite journal |vauthors=Irwin RS, Madison JM |title=The diagnosis and treatment of cough |journal=N. Engl. J. Med. |volume=343 |issue=23 |pages=1715–21 |year=2000 |pmid=11106722 |doi=10.1056/NEJM200012073432308 |url=}}</ref>
*<font size="3">'''[[Chronic Bronchitis]]:'''</font> may be caused by smoking, air pollutants and occupational exposures in a genetically susceptible person.


'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{CMG}}
==Classification==
Bronchitis is classified into two major categories based on symptom chronicity:
*[[Acute bronchitis]]
*[[Chronic bronchitis]]
==Differential diagnosis==


==[[Bronchitis overview|Overview]]==
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Organ System}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Disease}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Symptoms}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Signs}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Laboratory findings}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Diagnostic modality}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 colspan=1  | {{fontcolor|#FFFFFF|Management}}
|-
| colspan="1" rowspan="5" style="background: #4479BA; padding: 5px 5px;" |{{fontcolor|#FFFFFF|Cardiac}}
| style="padding: 5px 5px; background: #F5F5F5;" | HFpEF
| style="padding: 5px 5px; background: #F5F5F5;" |Exertional [[dyspnea]], reduced exercise tolerance, [[orthopnea]], [[paroxysmal nocturnal dyspnea]], edema
| style="padding: 5px 5px; background: #F5F5F5;" |Elevated [[Jugular venous pressure|JVP]], fine [[Rales|crackles]], [[edema]]
| style="padding: 5px 5px; background: #F5F5F5;" |Increased [[Brain natriuretic peptide|BNP]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Echocardiography]] (normal EF)
| style="padding: 5px 5px; background: #F5F5F5;" |Control of volume overload and [[hypertension]],
treatment of underlying condition ([[obesity]], [[Atrial fibrillation|AF]], [[coronary artery disease]], [[anemia]])
|-
| style="padding: 5px 5px; background: #F5F5F5;" |HFrEF
| style="padding: 5px 5px; background: #F5F5F5;" |Exertional [[dyspnea]], reduced exercise tolerance, [[orthopnea]], [[paroxysmal nocturnal dyspnea]], edema
| style="padding: 5px 5px; background: #F5F5F5;" |Elevated [[Jugular venous pressure|JVP]], fine [[Rales|crackles]], [[edema]]
| style="padding: 5px 5px; background: #F5F5F5;" |Increased [[Brain natriuretic peptide|BNP]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Echocardiography]] (reduced EF)
| style="padding: 5px 5px; background: #F5F5F5;" |[[Diuretics]], [[ACE inhibitor|ACE inhibitors]], [[Angiotensin II receptor antagonist|ARBs]], [[beta blockers]], [[nitrates]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |Pericardial disease
| style="padding: 5px 5px; background: #F5F5F5;" |Exercise intolerance, [[dyspnea]], [[fatigue]]
| style="padding: 5px 5px; background: #F5F5F5;" |Elevated [[Jugular venous pressure|JVP]], pericardial knock, [[kussmaul's sign]], [[pulsus paradoxus]]
| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
| style="padding: 5px 5px; background: #F5F5F5;" |Echocardiography, ECG
| style="padding: 5px 5px; background: #F5F5F5;" |Diuretics, [[pericardiectomy]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Hypertrophic cardiomyopathy]]
| style="padding: 5px 5px; background: #F5F5F5;" |Dyspnea, [[chest pain]], [[palpitation]], [[lightheadedness]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Systolic murmurs|Systolic murmur]]
| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
| style="padding: 5px 5px; background: #F5F5F5;" |Echocardiography, ECG
| style="padding: 5px 5px; background: #F5F5F5;" |[[Beta blockers]], [[verapamil]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |Valvular disease
([[Mitral regurgitation|MR]], [[Tricuspid regurgitation|TR]])
| style="padding: 5px 5px; background: #F5F5F5;" |Edema, [[fatigue]], exercise intolerance, dyspnea, [[lightheadedness]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Cardiac murmur]]
| style="padding: 5px 5px; background: #F5F5F5;" | <nowiki>-</nowiki>
| style="padding: 5px 5px; background: #F5F5F5;" |Echocardiography, ECG
| style="padding: 5px 5px; background: #F5F5F5;" |Valve repair or replacement, diuretics, [[beta blockers]]
|-
| colspan="1" rowspan="5" style="background: #4479BA; padding: 5px 5px;" |{{fontcolor|#FFFFFF|Pulmonary}}
| style="padding: 5px 5px; background: #F5F5F5;" |[[Chronic obstructive pulmonary disease|Chronic airway disease]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Cough]], dyspnea, chest pain, exercise intolerance
| style="padding: 5px 5px; background: #F5F5F5;" |Tachypnea, respiratory distress, [[cyanosis]], edema, [[rhonchi]] and [[crackles]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Hypoxemia]], hypercapnea, [[polycythemia]],
| style="padding: 5px 5px; background: #F5F5F5;" |[[PFTs|PFT]], chest imaging
| style="padding: 5px 5px; background: #F5F5F5;" |[[Bronchodilator|Bronchodilators]], [[Corticosteroid|corticosteroids]], [[Anticholinergic|anticholinergics]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Interstitial lung disease|Interstitial lung diseaee]]
| style="padding: 5px 5px; background: #F5F5F5;" |Exercise intolerance, cough
| style="padding: 5px 5px; background: #F5F5F5;" |Crackles, [[clubbing]], cyanosis
| style="padding: 5px 5px; background: #F5F5F5;" |Hypoxemia
| style="padding: 5px 5px; background: #F5F5F5;" |PFT, Chest imaging, lung biopsy
| style="padding: 5px 5px; background: #F5F5F5;" |Corticosteroids, bronchodilators
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Pulmonary hypertension]]
| style="padding: 5px 5px; background: #F5F5F5;" |Dyspnea, fatigue, chest pain, [[syncope]], [[palpitation]]
| style="padding: 5px 5px; background: #F5F5F5;" |Edema, clubbing, elevated [[Jugular venous pressure|JVP]], [[Tricuspid regurgitation|TR]] murmur
| style="padding: 5px 5px; background: #F5F5F5;" |Elevated BNP, elevated [[d-dimer]]
| style="padding: 5px 5px; background: #F5F5F5;" |Echocardiography, cardiac cathaterization
| style="padding: 5px 5px; background: #F5F5F5;" |Diuretics, [[Calcium channel blocker|calcium channel blockers]], [[endothelin receptor antagonist]], [[Sildenafil|phosphodiesterase 5 inhibitor]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Sleep apnea]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Snoring]], [[somnolence]], headache, fatigue, irritability
| style="padding: 5px 5px; background: #F5F5F5;" |Tachypnea, hypertension, tachycardia
| style="padding: 5px 5px; background: #F5F5F5;" |Hypoxemia, polycythemia
| style="padding: 5px 5px; background: #F5F5F5;" |[[Polysomnography]]
| style="padding: 5px 5px; background: #F5F5F5;" |Weight reduction, [[CPAP]]
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Asthma]]
| style="padding: 5px 5px; background: #F5F5F5;" |Dry [[cough]], [[dyspnea]], [[wheezing]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Wheezing]], [[tachypnea]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Hypoxemia]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[PFTs|PFT]]
| style="padding: 5px 5px; background: #F5F5F5;" |[[Bronchodilator|Bronchodilators]], [[Corticosteroid|corticosteroids]], [[Anticholinergic|anticholinergics]]
|}


==[[Bronchitis pathophysiology|Pathophysiology]]==
==References==
==[[Bronchitis causes|Causes]]==
{{Reflist|2}}
==[[Bronchitis differential diagnosis|Differentiating Bronchitis from other Diseases]]==


==[[Bronchitis epidemiology and demographics|Epidemiology and Demographics]]==
[[Category:Disease]]
 
[[Category:Up-To-Date]]
==[[Bronchitis risk factors|Risk Factors]]==
 
==[[Bronchitis natural history, complications and prognosis |Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Bronchitis history and symptoms|History and Symptoms]] | [[Bronchitis physical examination|Physical Examination]] | [[Bronchitis laboratory tests|Laboratory Findings]]| [[Bronchitis x ray|Chest X Ray]] | [[Bronchitis other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Bronchitis medical therapy|Medical Therapy]] | [[Bronchitis primary prevention|Primary Prevention]]
 
==Case Studies==
[[Bronchitis case study one|Case #1]]
 
 
[[Category:Inflammation]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:General practice]]
[[Category:Emergency medicine]]
[[Category:Pediatrics]]
[[Category:Infectious disease]]
[[Category:Infectious disease]]
[[Category:Overview complete]]
[[fr:Bronchite]]
[[ja:気管支炎]]
[[no:Bronkitt]]
[[pl:Zapalenie oskrzeli]]
[[pt:Bronquite]]
[[ru:Бронхит]]
[[sq:Bronkiti akut]]
[[tr:Bronşit]]
[[zh:支气管炎]]
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Latest revision as of 20:44, 29 July 2020

Bronchitis Main page

Patient Information

Overview

Causes

Classification

Acute bronchitis
Chronic bronchitis

Differential Diagnosis

For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Synonyms and keywords: Inflammation of bronchus

Overview

Bronchitis is an inflammation of the bronchi (medium and large size airways).[1] Acute bronchitis is a self-limiting disease usually caused by viruses or bacteria. Chronic bronchitis is a subtype of the chronic obstructive pulmonary disease (COPD), and it is defined as a chronic productive cough for at least three months in two consecutive years, after excluding other causes of chronic cough. The inflammatory response of the bronchial epithelium to infections or irritants that involve the medium and large-sized airways results in thickening of the bronchial and tracheal mucosa. Hallmark features of the pathophysiology of chronic bronchitis include hyperplasia and hypertrophy of the goblet cells of the airway, resulting in an increased mucus secretion, which contributes to the airway obstruction. Microscopically, there is infiltration of the walls of the airway with inflammatory cells, particularly neutrophils. Inflammation is followed by scarring and remodeling that thickens the walls, resulting in narrowing of the small airway. Further progression leads to metaplasia and fibrosis of the lower airway. The consequence of these changes is a limitation of airflow.[2][3][4] Acute bronchitis affects young children and old people. Its overall incidence is approximately 5% in the U.S. There is no racial or gender predilection for this disease.[5][6][7]Although chronic bronchitis is common among geriatric patients, it occurs more commonly among caucasian individuals compared to other races, and there is no sexual predilection.[8] Age, season of the year and the immunization status are the main determining risk factors for acquiring acute bronchitis.[9][6][10] The most potent risk factor in the development of chronic bronchitis is cigarette smoking.[11] Other risk factors are occupational pollutants such as cadmium and silica, air pollutants, and genetic factors such as alpha 1 antitrypsin deficiency[12] Acute bronchitis is a self limiting lower respiratory tract infection that usually presents with cough that lasts for up to 3 weeks.[9][13] Chronic bronchitis gradually worsens over time and can result in death. The rate of deterioration varies between individuals and depends on the level of airflow obstruction. The prognosis is dependent on early recognition and smoking cessation, which improves the outcome significantly. Smoking cessation, good hand hygiene, vaccination, and a reduction in occupational exposure to known risk factors, are important to ensure decreased severity and risk of bronchitis.[10][14]

Causes

  • Acute Bronchitis: may be caused by either viruses, bacteria or environmental factors.
Viruses: Influenza virus, parainfluenza virus, respiratory syncytial virus, coronavirus, adenovirus, enterovirus, rhinovirus, coxsackievirus, and human metapneumovirus[15][16][17]
Bacteria: Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Bordetella pertussis[6]
Environmental factors: Toxic fume inhalation, tobacco, dust, and aerosols[18]
  • Chronic Bronchitis: may be caused by smoking, air pollutants and occupational exposures in a genetically susceptible person.


Classification

Bronchitis is classified into two major categories based on symptom chronicity:

Differential diagnosis

Organ System Disease Symptoms Signs Laboratory findings Diagnostic modality Management
Cardiac HFpEF Exertional dyspnea, reduced exercise tolerance, orthopnea, paroxysmal nocturnal dyspnea, edema Elevated JVP, fine crackles, edema Increased BNP Echocardiography (normal EF) Control of volume overload and hypertension,

treatment of underlying condition (obesity, AF, coronary artery disease, anemia)

HFrEF Exertional dyspnea, reduced exercise tolerance, orthopnea, paroxysmal nocturnal dyspnea, edema Elevated JVP, fine crackles, edema Increased BNP Echocardiography (reduced EF) Diuretics, ACE inhibitors, ARBs, beta blockers, nitrates
Pericardial disease Exercise intolerance, dyspnea, fatigue Elevated JVP, pericardial knock, kussmaul's sign, pulsus paradoxus - Echocardiography, ECG Diuretics, pericardiectomy
Hypertrophic cardiomyopathy Dyspnea, chest pain, palpitation, lightheadedness Systolic murmur - Echocardiography, ECG Beta blockers, verapamil
Valvular disease

(MR, TR)

Edema, fatigue, exercise intolerance, dyspnea, lightheadedness Cardiac murmur - Echocardiography, ECG Valve repair or replacement, diuretics, beta blockers
Pulmonary Chronic airway disease Cough, dyspnea, chest pain, exercise intolerance Tachypnea, respiratory distress, cyanosis, edema, rhonchi and crackles Hypoxemia, hypercapnea, polycythemia, PFT, chest imaging Bronchodilators, corticosteroids, anticholinergics
Interstitial lung diseaee Exercise intolerance, cough Crackles, clubbing, cyanosis Hypoxemia PFT, Chest imaging, lung biopsy Corticosteroids, bronchodilators
Pulmonary hypertension Dyspnea, fatigue, chest pain, syncope, palpitation Edema, clubbing, elevated JVP, TR murmur Elevated BNP, elevated d-dimer Echocardiography, cardiac cathaterization Diuretics, calcium channel blockers, endothelin receptor antagonist, phosphodiesterase 5 inhibitor
Sleep apnea Snoring, somnolence, headache, fatigue, irritability Tachypnea, hypertension, tachycardia Hypoxemia, polycythemia Polysomnography Weight reduction, CPAP
Asthma Dry cough, dyspnea, wheezing Wheezing, tachypnea Hypoxemia PFT Bronchodilators, corticosteroids, anticholinergics

References

  1. Bronchitis (Chest Cold) - Get Smart: Know When Antibiotics Work. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/getsmart/community/for-patients/common-illnesses/bronchitis.html Accessed on July 28, 2016
  2. Cosio MG, Saetta M, Agusti A (2009). "Immunologic aspects of chronic obstructive pulmonary disease". N. Engl. J. Med. 360 (23): 2445–54. doi:10.1056/NEJMra0804752. PMID 19494220.
  3. Kumar P, Clark M (2005). Clinical Medicine, 6ed. Elsevier Saunders. pp 900-901. ISBN 0702027634.
  4. McDonough JE, Yuan R, Suzuki M, Seyednejad N, Elliott WM, Sanchez PG, Wright AC, Gefter WB, Litzky L, Coxson HO, Paré PD, Sin DD, Pierce RA, Woods JC, McWilliams AM, Mayo JR, Lam SC, Cooper JD, Hogg JC (2011). "Small-airway obstruction and emphysema in chronic obstructive pulmonary disease". N. Engl. J. Med. 365 (17): 1567–75. doi:10.1056/NEJMoa1106955. PMC 3238466. PMID 22029978.
  5. Macfarlane J, Holmes W, Gard P, Macfarlane R, Rose D, Weston V, Leinonen M, Saikku P, Myint S (2001). "Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community". Thorax. 56 (2): 109–14. PMC 1746009. PMID 11209098.
  6. 6.0 6.1 6.2 Wenzel RP, Fowler AA (2006). "Clinical practice. Acute bronchitis". N. Engl. J. Med. 355 (20): 2125–30. doi:10.1056/NEJMcp061493. PMID 17108344.
  7. Ferri FF. Ferri's Clinical Advisor 2016, 5 Books in 1. Elsevier Health Sciences; 2015.
  8. wrongdiagnosis.com > Prevalence and Incidence of COPD Retrieved on Mars 14, 2010
  9. 9.0 9.1 Gonzales R, Sande MA (2000). "Uncomplicated acute bronchitis". Ann. Intern. Med. 133 (12): 981–91. PMID 11119400.
  10. 10.0 10.1 Albert RH (2010). "Diagnosis and treatment of acute bronchitis". Am Fam Physician. 82 (11): 1345–50. PMID 21121518.
  11. MedicineNet.com - COPD causes
  12. MedlinePlus Medical Encyclopedia
  13. Landau LI (2006). "Acute and chronic cough". Paediatr Respir Rev. 7 Suppl 1: S64–7. doi:10.1016/j.prrv.2006.04.172. PMID 16798599.
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