Pulmonary nodule differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2], Joanna Ekabua, M.D. [3], Maria Fernanda Villarreal, M.D. [4]

Overview

Pulmonary nodule may be differentiated according to imaging (size, border characteristics, and attenuation), histological, and clinical features, from other diseases that demonstrate similar imaging findings. Common differential diagnoses of pulmonary nodule include hamartoma, granulomas, rheumatoid nodule, and metastatic lesions.

Differentiating Pulmonary Nodule from Other Diseases

• The table below summarizes the findings that differentiate pulmonary nodule from other conditions that cause similar radiological findings on CT scan of the chest.

ABBREVIATIONS:N/A: Not available , SOB: Shortness of breath, M/C: Most common
Diseases	Clinical manifestations							Para-clinical findings					Gold standard	Additional findings
	Symptoms						Physical exam
								Lab Findings	CT scan			Histopathology
	Productive cough	Hemoptysis	Weight loss	SOB	Fever	Other	Auscultation	Sputum analysis	Nodule	Nodule content	Other findings
Pulmonary Nodule(benign)	-	-	-	-	-	N/A	Normal Pleural friction rub Egophony Crackling or bubbling Whispered pectoriloquy Absent breath sounds	Normal	Single Round, oval <5 mm nodule Ground glass CT showing Ground glass opacity nodule. (Picture courtesy: Wikipedia)	Fat Calcification Types: Central dense nidus Diffuse solid Laminated Popcorn	Well-defined smooth border Growth rate > 18 months Cavity wall thickness of 1 mm CT showing Pulmonary hamartoma with well-defined smooth border. Case courtesy of Dr Domenico Nicoletti (Picture courtesy: Radiopaedia)	N/A	N/A	↓ O2 Sat
Pulmonary Nodule (malignant)	++	++	++	+	-	Recurrent pneumonia Wheezing Chest pain Cachexia Fatigue Anorexia Dysphonia Dysphagia	Normal Pleural friction rub Egophony Crackling or bubbling Whispered pectoriloquy Absent breath sounds	Tumor cells	Single or multiple Small or > 2 cm of size CT showing bronchogenic carcinoma. Case courtesy of Dr Ahmed Abdrabou (Picture courtesy: Radiopaedia)	Calcification Amorphous Punctate Reticular Stippled or eccentric Cavity Ulceration CT showing bronchogenic lung cancer with cavity Case courtesy of Dr Ahmed Abdrabou (Picture courtesy: Radiopaedia)	Spiculated border Rapid growth rate (Doubling time 1-18 months) Cavity wall thickness over 15 mm	Central necrosis Cavity: Lined bycancer cells No necrosis	Biopsy and histopathology	↓ O2 Sat
Diseases	Productive cough	Hemoptysis	Weight loss	SOB	Fever	Other	Auscultation	Sputum analysis	Nodule	Content	Other findings	Histopathology	Gold standard	Additional findings
Abscess	++	-	-	+	++	Pleuritic chest pain Foul smelling sputum Night sweats Fatigue	Decreased breath sound Bronchial breath sound Inspiratory crackles Localised crepitations	Causative agents	Vary in size Round in shape	Fluid/gas-fluid level Consolidation Cavity persists longer than consolidation CT showing lung abscess Case courtesy of Dr Vijay Mistry (Picture courtesy: Radiopaedia)	. The wall of the abscess is typically thick and the luminal surface is irregular Bronchial vessels and bronchi are truncated	Central necrotic tissue with necrotic granulocytes and bacteria Neutrophils Dilated blood vessels Inflammatory edema	Histopathology	Clubbing of finger
Septic pulmonary emboli	-	-	-	++	++	Chest pain Primary infection (M/C right heart endocarditis)	Prominent P2 component of second heart sound Decreased breath sound Rales Crackles Pleural friction rub	N/A	Multiple peripheral nodules Size 0.5 - 3.5 cm Variable shapes CT of a patient with angioinvasive aspergillosis Case courtesy of Dr Ahmed Abdrabou (Picture courtesy: Radiopaedia)	Central low attenuation Feeding vessels Pleura based wedge-shaped lesions CT of a patient with angioinvasive aspergillosis Case courtesy of Dr Ahmed Abdrabou (Picture courtesy: Radiopaedia)	Air bronchogram Abscess or infection related changes at the primary focus	N/A	Culture and sensitivity	N/A
Fungal infection	+/-	+	-	+	+	Chest pain Hypersensitivity Allergic reactions History of travel	Decreased breath sound Rales Crackles Pleural friction rub	KOH stain: Fungi	Multiple nodules Size 0.5 - 3 cm Nodules surrounded by ground-glass opacity/halo CT of a patient with angioinvasive aspergillosis Case courtesy of Assoc Prof Frank Gaillard (Picture courtesy: Creativecommons)	Cavity	Halo sign in aspergillosis Patchy infiltrate Consolidation Mediastinal adenopathy	Causative agent	Culture and sensitivity	N/A
Parasites	+/-	+/-	+/-	_	+	Asymptomatic Chest pain Pneumothorax Wheeze Urticaria Anaphylaxis (rarely)	Decreased breath sound Rales Crackles	N/A	Cysts: Single or multiple well-defined homogenous Coin lesion: 1 - 3 cm	Cyst: Fluid or gas Worm Coin lesion: Central necrotic Granulomatous reaction and fibrous wall	Calcified cyst wall Consolidation Pleural effusion Worm	Larvae or eggs Microfilaria(larva) of loa loa (Picture courtesy: Creativecommons)	Visualization of parasite, egg or larvae	N/A
Diseases	Productive cough	Hemoptysis	Weight loss	SOB	Fever	Other	Auscultation	Sputum analysis	Nodule	Content	Other findings	Histopathology	Gold standard	Additional findings
Mycobacterial infections	+	+	+	++	+/-	Chronic cough Night sweats Dyspnea Wheezing Cachexia Fatigue Loss of appetite	Decreased breath sounds Rales Rhonchi Bronchial breath sounds	AFB+	Micronodules in the subpleural region and peribronchovascular interstitium Fluffy upper zone shadowing Cavity	Superinfected cavities shows air-fluid level CT showing cavitating lesion with air-fluid level. Case courtesy of Dr Ayush Goel (Picture courtesy: Radiopaedia)	Fluffy upper zone shadowing Interlobular septal thickening Homogeneous and dense consolidation	Granulomas: necrotizing/non-necrotizing Langhans giant cells Caseous necrosis	Culture and sensitivity	N/A
Chronic inflammatory conditions (Granulomatosis with polyangiitis)	+/-	+	-	+	-	Hoarseness Chest pain Stridor	Pleural friction rub Absent breath sound Crackles	N/A	Multiple round lesions Size 0.5 - 10 cm CT showing multiple lung nodules bilaterally Case courtesy of Dr Abdallah Al Khateeb (Picture courtesy: Radiopaedia)	Patchy or diffuse ground-glass opacities, or both	Cavity Thick wall Irregular inner contour Atelectasis	Pathologic triad of granulomatous inflammation, vasculitis, and necrosis Micrograph of Granulomatosis with polyangiitis (Picture courtesy: Wikipedia)	Biopsy	c-ANCA p-ANCA
Diseases	Productive cough	Hemoptysis	Weight loss	SOB	Fever	Other	Auscultation	Sputum analysis	Nodule	Content	Other findings	Histopathology	Gold standard	Additional findings
Pulmonary AVMs	-	+/-	-	+	-	Epistaxis Palpitation Chest pain GI bleeding Mucocutaneous telangiectasia	Bruit	RBCs	Solitary or multiple nodules Round, oval, or polycyclic Size 1 - 5 cm	Feeding pulmonary arteries and draining pulmonary veins CT showing pulmonary arteriovenous malformation Case courtesy of Dr Vikas Shah (Picture courtesy: Radiopaedia)	Well-defined borders Lower and middle third of the lung CT showing pulmonary arteriovenous malformation Case courtesy of Dr Vikas Shah (Picture courtesy: Radiopaedia)	Not done	Pulmonary angiography	Solitary rounded opacity on X-ray X-ray showing pulmonary arteriovenous malformation Case courtesy of Dr Vikas Shah (Picture courtesy: Radiopaedia)
Pneumoconiosis	+	-	+	+	-	Chest pain	Fine crackles Rhonchi Bronchial breath sounds Expiratory wheezing Egophony Bronchophony	Inorganic particle	Solitary or multiple nodules Size 1 - 10 cm In the upper lobes	N/A	Massive fibrosis or conglomerate masses Small nodular opacities Pleural plaques Lymphadenopathy, eggshell calcification X-ray showing pleural plaques in a patient with asbestosis (Picture courtesy: Medpix)	Calcification Central necrosis Dense collagen Malignant cells Ferruginous bodies Pneumoconiosis due to asbestosis showing ferruginous bodies (Picture courtesy: Wikipedia)	CT scan CT scan showing multifocal areas of ground-glass opacities in a patient with hard-metal pneumoconiosis. Case courtesy of Dr Azza Elgendy (Picture courtesy: Radiopaedia)	N/A
ABBREVIATIONS:N/A: Not available , SOB: Shortness of breath, M/C: Most common