Tetralogy of fallot medical treatment
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. ; Associate Editors-In-Chief: Priyamvada Singh, MBBS ; Cafer Zorkun, M.D., Ph.D. ; Keri Shafer, M.D. ; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. 
Although operative repair of tetralogy of Fallot is definitive, medical therapy can be used to manage hypoxic or tet spells. Tet spells cause acute hypoxia and may be treated with beta blockers, morphine, phenylephrine, and oxygen.
Emergency Medical Management of Tet Spells
- Beta-blockers such as propranolol or esmolol. The beta-blockers causes relaxation of the right ventricular outflow tract and increases blood flow into the pulmonary vessels.
- Morphine to reduce ventilatory drive
- Phenylephrine to increase systemic afterload that in turn increases the flow across right ventricle and the pulmonary artery and decreases right to left shunting.
- Procedures such as the knee-chest position which increases aortic wave reflection, increasing pressure on the left side of the heart, decreasing the right-to-left shunt thus decreasing the amount of deoxygenated blood entering the systemic circulation.
- Oxygen is ineffective in treating hypoxic spells as the underlying problem is lack of blood flow through the pulmonary circuit and not alveolar oxygenation.
- In case all these measures fail, an emergency Blalock-Taussig shunt might be needed.
- Prostaglandins can be administered while awaiting surgery to maintain patency of the ductus arteriosus.
- Antibiotic prophylaxis is suggested to prevent infective endocarditis, particularly in the repaired tetralogy of Fallot patient with a patch.
- Murakami T (2002). "Squatting: the hemodynamic change is induced by enhanced aortic wave reflection". Am. J. Hypertens. 15 (11): 986–8. PMID 12441219.
- Abe K, Shimada Y, Takezawa J, Oka N, Yoshiya I (March 1982). "Long-term administration of prostaglandin E1: report of two cases with tetralogy of Fallot and esophageal atresia". Crit. Care Med. 10 (3): 155–8. doi:10.1097/00003246-198203000-00003. PMID 7199417.
- Tsze DS, Vitberg YM, Berezow J, Starc TJ, Dayan PS (July 2014). "Treatment of tetralogy of Fallot hypoxic spell with intranasal fentanyl". Pediatrics. 134 (1): e266–9. doi:10.1542/peds.2013-3183. PMID 24936003.