PCI equipment: guiding catheter selection

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Editors-In-Chief: Alexandra Almonacid M.D.; Jeffrey J.Popma M.D. Associate Editor(s)-in-Chief: Muhammad Saad, M.B.B.S.[1]

Overview

Diagnostic catheters used for coronary arteriography are usually constructed from polyethylene or polyurethane with a fine wire braid within the wall to allow advancement and directional control (torquability) and to prevent kinking. The outer diameter size of the catheters ranges from 4 to 8F, but 5 and 6F catheters are used most commonly for diagnostic arteriography. Guiding catheters for percutaneous coronary intervention (PCI) differ from diagnostic catheters in that they have larger internal lumens, stiffer shafts for backup support, and atraumatic soft tips to minimize coronary artery injury. Selection of the appropriate guiding catheter is a critical determinant of procedural success, as it must provide coaxial alignment with the coronary ostium, adequate backup support for device delivery, and sufficient internal diameter for the planned interventional equipment.

Guiding Catheter Selection

General Principles

Guiding catheter selection should balance the feasibility of engaging the coronary artery with adequate support to complete the procedure.[1] Two types of backup support are recognized:

Passive support: The catheter body rests against the contralateral aortic wall (e.g., EBU/XB catheters seated in the contralateral sinus of Valsalva for left coronary artery PCI), providing support without active operator manipulation.[1]

Active support: Operator-applied torque and push to increase engagement force (e.g., deep-seating of the guide catheter into the coronary artery).[1]

Dedicated transradial access (TRA) guide catheters (Ikari left, MAC, Kimny) provide the option of passive or active support depending on the technique of engagement.[1]

Guiding Catheter Size

The majority of PCIs — including treatment of complex bifurcation lesions, use of covered stents, and aspiration devices — can be performed via 6F guide catheters.[1] A prospective, multicenter, randomized trial of 460 patients demonstrated that 6F guides had similar angioplasty success rates to 7F/8F guides (87% vs. 88%) with significantly fewer femoral complications (13.8% vs. 23.5%; P<0.01), less contrast use (136±68 vs. 168±95 mL; P<0.0001), and shorter procedural time (36±22 vs. 41±28 min; P<0.01).[2]

Larger guide catheters are required for specific situations:[1]

Use of an aspiration device with two 0.014-inch wires in the coronary artery

Rotational atherectomy burrs >1.75 mm

Simultaneous deployment of 2 stents

For larger guides via radial access, sheathless guide techniques or thin-walled 7-in-6F sheaths may be used.[1]

Guiding Catheter Size Requirements by Procedure Type

Procedure / Device Minimum Guide Catheter Size Notes
Standard PCI (single stent, single balloon) 6F Sufficient for the majority of PCI procedures
Rotational atherectomy burr 1.25–1.5 mm 6F Standard 6F inner diameter adequate
Rotational atherectomy burr 1.75 mm Large 6F (0.071-inch ID) or 7F Requires larger inner diameter than standard 6F
Rotational atherectomy burr 2.0 mm Large 7F (0.081-inch ID) or 8F
Rotational atherectomy burr 2.15 mm 8F
Bifurcation PCI: provisional stenting, T-stent, reverse crush, step crush 6F Second stent advanced after first is positioned
Bifurcation PCI: standard crush, V/simultaneous kissing stents ≥7F (0.081-inch ID) or ≥8F (0.088-inch ID) Depends on stent platform
Bifurcation PCI: modified T technique ≥7F
Bifurcation PCI: culottes, Y, skirt techniques ≥8F
Chronic total occlusion PCI 7F–8F preferred 8F recommended for complex cases; 7F adequate for most contemporary techniques
Left main PCI (standard) 6F (EBU 3.5/3.75 or JL 3.5/4.0) Side holes recommended if left main ostium is diseased
Left main PCI (complex: large arteries, RA burr >1.75 mm, simultaneous 2-stent delivery) 7F or 8F

Sources: SCAI Expert Consensus Statement on Calcified Coronary Lesions (2024)[3]; Iakovou et al., JACC (2005)[4]; Rab et al., JACC Cardiovasc Interv (2017)[5]

Judkins Catheters

The left Judkins catheter has been developed to allow entry into the left coronary ostium from the femoral approach with minimal catheter manipulation. A preformed left Judkins catheter can also be used from the left brachial or radial artery, but a catheter with 0.5 cm less curvature than required for the femoral approach is generally better suited for coronary cannulation. The right Judkins catheter is shaped to permit entry into the right coronary artery (RCA) with a small amount of rotational (clockwise) catheter manipulation from any vascular approach.

Selection of Judkins catheter shape is based on the body habitus of the patient and size of the aortic root. The left coronary artery (LCA) is easily engaged with the Judkins left 4.0 catheter from the femoral approach in most patients, whereas patients with a dilated ascending aorta (e.g., in the setting of congenital aortic stenosis and post-stenotic dilation) may require the use of a Judkins left 5.0 or 6.0 catheter.

Patients with large ascending aortic aneurysms may require arteriography with heat-modified catheters to achieve Judkins left 7.0 to 10.0 shapes. Use of a Judkins shape that is too small for the ascending aorta often leads to folding of the catheter within the aortic root. The best technique for removing a folded Judkins left catheter from the body involves withdrawing the folded catheter into the descending aorta and advancing a guidewire anterograde in the contralateral common iliac artery. On withdrawal of the catheter and guidewire together, the catheter straightens and can be removed safely from the body without disrupting the arterial access site.

For diagnostic coronary angiography, an international survey of 987 operators across 6 continents found that Judkins left 4.0 was the most commonly used catheter for LCA angiography (77%) and Judkins right 4.0 for RCA angiography (73%).[6] For interventional procedures, XB 3.5 (29%) and EBU 3.5 (25%) were the most preferred guide catheters for LAD and LCx PCI, while the Judkins right guide catheter was preferred by 86% of operators for RCA PCI.[6]

Amplatz Catheters

Amplatz catheters can be used for the femoral or brachial approach to coronary arteriography. The Amplatz catheters are an excellent alternative in cases in which the Judkins catheter is not appropriately shaped to enter the coronary arteries. The Amplatz L-1 or L-2 catheter may be used for coronary angiography from the right brachial or radial approach and can provide excellent passive backup support for more complex interventions.[1] A modified right Amplatz catheter (AR-1 or AR-2) can be used for engagement of a horizontal or upward takeoff RCA or SVG.

Extra Backup (EBU/XB) Catheters

For left coronary artery PCI, most operators prefer extra backup single-curve guide catheters (e.g., EBU, XB, Voda).[1][6] These catheters offer passive backup support from the contralateral sinus of Valsalva and provide deep-seating capability. Smaller curves tend to point upward and preferentially engage the LAD, while larger curves direct downward to better engage the circumflex.[1]

Dedicated Transradial Access (TRA) Catheters

Although a multiple-catheter strategy using Judkins-shaped catheters is preferred among the majority of operators (JR 4.0 for RCA, JL 3.5 for LCA if right radial, JL 4.0 for LCA if left radial), dedicated TRA catheters (e.g., Kimny, Tiger, Jacky, DxTerity, Ultimate) allow a single catheter to be used to engage either coronary ostium.[1]

For primary PCI in STEMI, the single-guide catheter technique with an extra backup (3.5 or 3.75) or dedicated TRA guide catheters (Ikari left, MAC, Kimny) can engage either the right or left coronary artery and provide the option of passive or active support, depending on the technique of engagement.[1]

Other Catheters

Other catheters used for coronary arteriography include the left IMA catheter with an angulated tip that allows engagement of the IMA or an upward takeoff RCA. Catheter shapes that permit engagement of SVGs include the multipurpose catheter, right Judkins, modified right Amplatz, and hockey stick catheters. Specially designed catheters for engagement of the coronary arteries from the radial artery have also been developed.

Catheter Selection by Target Vessel

Left Coronary Artery System

Clinical Scenario Preferred Guide Catheter(s) Alternative(s)
Standard LAD/LCx PCI EBU 3.5/3.75, XB 3.5 Amplatz left 1 or 2; Voda
Left main PCI (standard) EBU 3.5/3.75 or JL 3.5/4.0 (with side holes if ostium diseased)
Left main PCI (complex: large arteries, RA burr >1.75 mm, 2-stent delivery) 7F or 8F EBU or JL
Transradial LCA PCI EBU 3.5/3.75, XB 3.5 Ikari left, MAC, Kimny (single-catheter technique)
Primary PCI (STEMI) EBU 3.5/3.75 (single-catheter technique) Ikari left, MAC, Kimny

Sources: AHA Scientific Statement (2018)[1]; Damluji et al. (2017)[6]; Rab et al. (2017)[5]

Right Coronary Artery System

The right coronary artery takeoff varies considerably more than the left coronary artery, necessitating a broader range of catheter shapes to accommodate anatomical differences.

RCA Takeoff / Anatomy Preferred Guide Catheter(s) Alternative(s)
Horizontal (standard) JR 4.0
Superior takeoff JR, Hockey Stick, Amplatz left Kiesz Right Superior
Inferior takeoff Multipurpose
Dilated aortic root / shepherd's crook origin Amplatz left (0.75 or 1), MAC (3.0 or 4.0) XB-RCA, Ikari left (3.5 or 4.0)
Anterior origin Amplatz left (0.75 or 1) MAC, XB-RCA

Sources: AHA Scientific Statement (2018)[1]; Damluji et al. (2017)[6]

Saphenous Vein Grafts

Graft Target Preferred Guide Catheter(s) Notes
SVG to RCA Multipurpose Shape of choice via radial or femoral; JR rarely effective for vertical grafts; AL1/AL2 may require more manipulation
SVG to LCx/diagonal JR catheter or AL1/AL2 High and posterior takeoff can be challenging and may require large Amplatz guide
LIMA to LAD Classic IMA catheter Left radial access preferred; extreme subclavian tortuosities can make selective cannulation problematic

Globally, the JR4 catheter is the most commonly used for both left and right SVG PCI. However, in North America, operators prefer the Amplatz left catheter for left SVGs (37%) and the multipurpose catheter for right SVGs (43%).[6]

Sources: Damluji et al. (2017)[6]

Anomalous Coronary Arteries

Engagement of anomalous coronary arteries requires careful preprocedural planning. A deep aortic root angiogram in anteroposterior (AP) and lateral projections is recommended first to identify the origin before catheter selection.[7]

Anomalous Origin Preferred Guide Catheter(s) Notes
Anomalous RCA from left cusp (adjacent to LM) Leya catheter (Amplatz left 90°), R-ACAOS Launcher guide (6F), EBU catheter Most technically challenging; EBU achieved 100% success in Type A (above LCA) and 83.3% in Type B (below LCA)
Anomalous RCA from left cusp (inferior to LM or toward commissure) Amplatz left 1, 2, or 3; Amplatz right 1, 2, or 3 Size selection based on aortic root dimensions
Anomalous RCA from commissure or ascending aorta JR4, Hockey Stick, Multipurpose, Amplatz left/right
When selective engagement cannot be achieved Guide extension catheter (GuideLiner) advanced over coronary guidewire Provides selective engagement when standard catheters fail

Sources: Ben-Dor et al., JACC Cardiovasc Interv (2021)[7]; Gebremedhin et al., PLoS One (2025)[8]

Vascular Access and Catheter Selection

The 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for ACS recommends a radial approach (Class 1, Level of Evidence A) for patients with acute coronary syndrome undergoing PCI to reduce bleeding, vascular complications, and death.[9] The 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization similarly endorses radial access as Class 1, Level of Evidence A for both ACS and stable ischemic heart disease PCI.[10]

The SCAI Expert Consensus Update on Best Practices in the Cardiac Catheterization Laboratory (2021) recommends that all operators develop and maintain competency in both radial and femoral arterial vascular access, and that vascular ultrasound should be available for universal use.[11] The choice of right versus left radial access depends on patient age and height (higher incidence of right subclavian tortuosity in older and shorter patients), presence of hemodialysis fistula grafts, presence of internal mammary artery bypass grafting (favor ipsilateral radial access), and prior procedural difficulty.[11]

Transfemoral access should be considered when temporary mechanical circulatory support is planned and is the default alternative access site when the radial artery cannot be used.[9]

Inadequate support accounts for 7% to 17% of transradial PCI failures, but this becomes less relevant as operator experience increases.[1]

Catheter Selection for Specific Complex PCI Scenarios

Chronic Total Occlusion PCI

Access site selection is critical in chronic total occlusion (CTO) PCI for providing appropriate support and allowing simultaneous use of multiple devices. Many operators recommend 8F guiding catheters, mostly via transfemoral access, for CTO PCI.[12] Currently, most CTO techniques — including antegrade dissection and re-entry with the Stingray LP system and simultaneous IVUS-controlled cap puncture — can be performed with 7F guide catheters using 7F-compatible equipment combinations (e.g., 5F IVUS and low-profile microcatheters).[13] Eight-French guide catheters are still needed for more complex antegrade IVUS-controlled re-entry cases and for ipsilateral single-guide retrograde cases with simultaneous IVUS guidance.[13]

Biradial CTO PCI is increasingly performed using 7F slender sheaths or sheathless 8F transradial guides. However, complex cases (J-CTO score ≥3) performed via transradial access had significantly lower technical success than transfemoral (35.7% vs. 58.2%; P=0.004).[12]

Dual arterial access is commonly used (bifemoral, biradial, femoral-radial) for contralateral injection, which is critical for CTO PCI and should be performed in every case where contralateral collaterals exist.[14]

Left Main PCI

Left main PCI can be performed via femoral or radial access with 6F EBU 3.5/3.75 or JL 3.5/4.0 guiding catheters (with side holes if the left main ostium is diseased).[5] Routine intravascular imaging is recommended for left main PCI.[15] For complex left main bifurcation lesions (Medina 1,1,1 or 0,1,1 with side branch lesion ≥70% and length ≥10 mm), an upfront DK crush (preferred) or other two-stent technique is recommended, which may necessitate ≥7F guide catheters to accommodate simultaneous stent delivery.[15][5] Ad hoc unprotected left main PCI is discouraged.[15]

Guide Catheter Extensions

Guide catheter extensions (GCEs) are coaxial catheters that are advanced through the guiding catheter and into the coronary artery to provide additional backup support and facilitate device delivery. They have become indispensable for contemporary complex PCI, particularly chronic total occlusion PCI.[16]

Available Devices

Currently available GCE devices include:[16]

GuideLiner V3 (Teleflex)

TrapLiner (Teleflex)

Guidezilla II (Boston Scientific)

Telescope (Medtronic)

Guidion (IMDS)

Expressman (ATP Medical)

Boosting Catheter (QX Medical)

LiquID (Seigla Medical)

Key Applications

Increasing backup support for wire crossing in CTO PCI and heavily calcified lesions[16]

Facilitating balloon/stent delivery in uncrossable lesions where standard guide catheter support is insufficient[16]

"Reach and capture" of retrograde microcatheter during retrograde CTO PCI[16]

Selective engagement of anomalous coronary arteries when standard catheters fail[7]

Advancing Techniques

The preferred contemporary approach for advancing GCEs is the "inchworming" technique, in which the GCE and guidewire/balloon are alternately advanced in small increments. Other techniques include distal anchoring (inflating a balloon distally to provide a rail for GCE advancement) and balloon tracking (advancing the GCE over an inflated balloon).[16]

Clinical Evidence

A study of 188 patients in whom the Guidezilla catheter was used (most commonly for CTOs [45%] and heavy proximal calcification [37%]) demonstrated target lesion crossing success and procedural success rates of 99%, with one device-related complication (proximal vessel dissection from deep insertion, treated with stent). Ninety percent of procedures were completed via radial access.[17]

A series of 54 patients using the GuideLiner for complex PCI (CTO [39%], anomalous/angulated takeoff [31%], previously deployed proximal stents [15%], heavy calcification [9%], tortuosity [7%]) showed a procedural success rate of 98% with no device-related periprocedural complications.[18]

Complications of Guiding Catheter Use

Major PCI complications occur in 0.2% to 3.2% of cases (higher in AMI and high-risk PCI).[19] Catheter-related complications include:

Coronary artery dissection: Can result from aggressive catheter engagement, deep-seating, or forceful contrast injection. Management includes confirming intraluminal guidewire position, brief balloon inflations, and stenting.[20]

Coronary perforation: May occur with deep-seating of guide catheters or guide extensions, particularly in tortuous or calcified vessels.[20]

Air embolism: Can result from inadequate flushing of the guide catheter or guide extension system.[20]

Abrupt vessel closure (AVC): Incidence has decreased from approximately 3% in the plain old balloon angioplasty (POBA) era to approximately 0.3% with contemporary techniques. Mechanisms include dissection, intracoronary thrombus, native thrombus/atheroma embolization, air injection, and spasm.[20]

Vascular access complications: Ischemic limbs, retroperitoneal bleeding, AV fistulas, pseudoaneurysms, and expanding hematomas — significantly lower with radial access compared with femoral access.[19]

References

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