Myasthenia gravis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Natural history: The age of onset before age of 50 is female predominant and after age of 60 is male predominant. Between the age of 50-60 there is no significant different between male and female. About 50 percent of patiens have ptosis and diplopia as their presenting sign. Complications: Complications from the treatment of myasthenia gravis such as: Glucocorticoids, azathioprine, cyclosporine, tacrolimus, cyclophosphamide, plasmapheresis, intravenous immune globulin and myasthenia crises (Respiratory failur). The prognosis of myasthenia gravis depends on: Disease duration at diagnosis, disease severity and the age of onset.

Natural History, Complications, and Prognosis

Natural History


Complications that can develop as a result of myasthenia gravis are:

  • Myasthenia crises (Respiratory failur): because of respiratory muscle weakness, MG patients may experience crises in which the respiratory weakness is so severe that may result in intubation.[42]
  • since the myasthenia is a chronic disease,most of the Complications that can develop as a result of this disease, may be equal to disease symptoms.


The prognosis of myasthenia gravis depends on:

  • Disease duration at diagnosis: If the symptoms last less than 1 year, the patient has a 25 percent chance of going into remission by 10 years.[43]
  • Disease severity[43]
  • The age of onset: Younger patients seems to have better chance for remission than older ones.[43] Patients more than 50 years old are more prone to myasthenia crises like respiratory failure.[21]


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