Myasthenia gravis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Fahimeh Shojaei, M.D.


Myasthenia gravis is a neuromuscular disease caused by an autoimmune reactions. The main problem in this disease is the abnormal transmission of nerve impulses to muscle fibers in NMJ. Genes involved in the pathogenesis of Myasthenia gravis include: The Major Histocompatibility Complex, the CHRNA1 Locus, the PTPN22 Gene, the FCGR2 Locus and the CTLA4 Locus.





Genes involved in the pathogenesis of Myasthenia gravis include:

Associated Conditions

Conditions associated with Myasthenia gravis include:

  • Thymus abnormalities:
    • Thymus abnormalities including thymic hyperplasia and thymoma are very common in myasthenia gravis and thymectomy is one of the treatment of this disease.[31][32]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].


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