Histoplasmosis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]


The gold standard for diagnosis of histoplasma infection is direct visualization of the oviod yeast cells in the tissue samples and body fluid specimen. Antigen testing is an useful method for rapid diagnosis of histoplasma infection.

Other Diagnostic Studies



Antigen Testing

Antibody Testing

Molecular Testing



  1. Azar MM, Hage CA (2017). "Laboratory diagnostics for Histoplasmosis". J Clin Microbiol. doi:10.1128/JCM.02430-16. PMID 28275076.
  2. 2.0 2.1 Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ (2015). "Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management". Semin Respir Crit Care Med. 36 (5): 729–45. doi:10.1055/s-0035-1562899. PMID 26398539.
  3. Cunningham L, Cook A, Hanzlicek A, Harkin K, Wheat J, Goad C; et al. (2015). "Sensitivity and Specificity of Histoplasma Antigen Detection by Enzyme Immunoassay". J Am Anim Hosp Assoc. 51 (5): 306–10. doi:10.5326/JAAHA-MS-6202. PMID 26355580.
  4. Dieng T, Massaly A, Sow D, Vellaissamy S, Sylla K, Tine RC; et al. (2017). "Amplification of blood smear DNA to confirm disseminated histoplasmosis". Infection. doi:10.1007/s15010-017-0989-0. PMID 28214953.
  5. Damasceno LS, Leitão TM, Taylor ML, Muniz MM, Zancopé-Oliveira RM (2016). "The use of genetic markers in the molecular epidemiology of histoplasmosis: a systematic review". Eur J Clin Microbiol Infect Dis. 35 (1): 19–27. doi:10.1007/s10096-015-2508-5. PMID 26589702.
  6. 6.0 6.1 6.2 6.3 6.4 "Public Health Image Library (PHIL)".