Diffuse large B cell lymphoma risk factors
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There are several factors including family history, old age, male gender, white ethnicity, geography, certain viruses, exposure to certain drugs and chemicals, radiation exposure, autoimmune diseases, and weak immune system that can increase the chances of getting Non-Hodgkin Lymphoma (NHL). Diffuse Large B cell Lymphoma ((DLBC) is the most common sub-type.On the other hand, factors that are associated with a decreased risk of DLBCL include blood transfusion, alcohol consumption, vegetables consumption, sun exposure, and allergies.
Factors that increase the risk:
Genetic susceptibility is an important risk factor. TNF/LTA; 6p25.3; 6p21.33; 2p23.3; 8q24-21 loci have been identified.
The overall risk of Non-Hodgkin Lymphoma is higher in men than in women, but there are certain types that are more commonly seen in women. Reasons for this finding are unknown.
Race, Ethnicity and Geography:
Worldwide, it is more common in developed countries with USA and Europe having the highest prevalence.
Drug and Chemical Exposure:
Some chemicals like Benzene and Herbicides and Insecticides may be associated with an increased risk of NHL but research is in progress to clarify these links. Some chemotherapeutic drugs might be associated as a treatment for Hodgkin Lymphoma increases the risk of NHL but it is unclear whether it is treatment related or related to disease itself.
There is an increased risk of many types of cancers in people exposed to high intensity. It has been reported that survivors of several nuclear reactor accidents and atomic bombs tend to have certain types of cancers including NHL, Leukemia and Thyroid cancer. Also, people with Hodgkin Lymphoma who get treated with radiotherapy have a slightly increased incidence to develop NHL later in life.
There is an increased risk of NHL in people with immunodeficiency. Examples include organ transplant recipients who are on immunosuppressive drugs, HIV Infection. Some genetic conditions in which children are born with weak immune system like Wiskott-Aldrich Syndrome and Ataxia-telengectasia(AT) also have a higher risk of NHL. However, type 2 diabetes mellitus has no significant effect.
Factors that decrease the risk:
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