Diffuse large B cell lymphoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]

Overview

The most common symptoms of diffuse large B cell lymphoma include a rapidly enlarging, non-painful mass that may be located in neck, groin, or abdomen. The less common symptoms of diffuse large B cell lymphoma include fever, weight loss, and drenching night sweats also known as ''B symptoms"[1][2].

Common Symptoms

  • Mass/Lump
  • Rapidly enlarging lump (enlarged lymph nodes)
  • Painless
  • May be present in neck, groin or abdomen
  • It is not uncommon to have lymphoma outside the Lymph nodes(Extranodal sites) and can lead to the rapid Progression to Large lumps.
  • Localized symptoms:

Other symptoms might depend on the organ of Involvement for example DLBCL in Chest can lead to shortness of breath or cough while DLBCL involving gut or Stomach can cause Abdominal Pain/ Diarrhea/ Bleeding etc.

Constitutional/B Symptoms


References

  1. Swerdlow SH, et al (editors). WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edition. 2008. International Agency for Research on Cancer (IARC), Lyon, Franc
  2. Tilly H, et al. Diffuse large B-cell lymphoma (DLBCL): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2015; 26: v116-v125


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