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{{Infobox_gene}}
{{PBB_Controls
'''Transient receptor potential cation channel, subfamily C, member 6''', also known as '''TRPC6''', is a [[human]] [[gene]] encoding a [[protein]] of the same name. TRPC6 is a [[transient receptor potential]] [[ion channel]]. It has been associated with [[Depression (mood)|depression]] and [[anxiety]] (see [[TRPC6#Ligands|below]]), as well as with [[focal segmental glomerulosclerosis]] (FSGS).<ref>{{cite journal | vauthors = Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB | title = A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis | journal = Science | volume = 308 | issue = 5729 | pages = 1801–4 | date = June 2005 | pmid = 15879175 | doi = 10.1126/science.1106215 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Transient receptor potential cation channel, subfamily C, member 6
| HGNCid = 12338
| Symbol = TRPC6
| AltSymbols =; FLJ11098; FLJ14863; FSGS2; TRP6
| OMIM = 603652
| ECnumber = 
| Homologene = 37944
| MGIid = 109523
<!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
| DateOfBotUpdate = 06:57, 9 October 2007 (UTC)
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015279 |text = store-operated calcium channel activity}} {{GNF_GO|id=GO:0015281 |text = cation channel activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7225
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004612
    | Hs_RefseqmRNA = NM_004621
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 22068
    | Mm_Ensembl = ENSMUSG00000031997
    | Mm_RefseqmRNA = NM_013838
    | Mm_RefseqProtein = NP_038866
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 8544711
    | Mm_GenLoc_end = 8642583
    | Mm_Uniprot = Q61143
  }}
}}
'''Transient receptor potential cation channel, subfamily C, member 6''', also known as '''TRPC6''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TRPC6 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[FYN]],<ref name = pmid14761972>{{cite journal | vauthors = Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K | title = Regulation of TRPC6 channel activity by tyrosine phosphorylation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 18887–94 | date = April 2004 | pmid = 14761972 | doi = 10.1074/jbc.M311274200 }}</ref>
| section_title =  
* [[TRPC2]],<ref name = pmid14699131>{{cite journal | vauthors = Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA | title = Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 10514–22 | date = March 2004 | pmid = 14699131 | doi = 10.1074/jbc.M308478200 }}</ref>  and
| summary_text =  
* [[TRPC3]].<ref name = pmid12032305>{{cite journal | vauthors = Hofmann T, Schaefer M, Schultz G, Gudermann T | title = Subunit composition of mammalian transient receptor potential channels in living cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7461–6 | date = May 2002 | pmid = 12032305 | pmc = 124253 | doi = 10.1073/pnas.102596199 }}</ref>
}}
'''TRPC6''' is a [[transient receptor potential]] [[ion channel]] associated with [[focal segmental glomerulosclerosis]].<ref>{{cite journal |author=Winn MP, Conlon PJ, Lynn KL, ''et al'' |title=A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis |journal=Science |volume=308 |issue=5729 |pages=1801-4 |year=2005 |pmid=15879175 |doi=10.1126/science.1106215}}</ref>


==References==
== Ligands ==
{{reflist|2}}


Two of the primary [[active constituent]]s responsible for the [[antidepressant]] and [[anxiolytic]] [[therapeutic effect|benefit]]s of ''[[Hypericum perforatum]]'', also known as St. John's Wort, are [[hyperforin]] and [[adhyperforin]].<ref name="pmid11518085">{{cite journal | vauthors = Müller WE, Singer A, Wonnemann M | title = Hyperforin--antidepressant activity by a novel mechanism of action | journal = Pharmacopsychiatry | volume = 34 Suppl 1 | pages = S98-102 | date = July 2001 | pmid = 11518085 | doi = 10.1055/s-2001-15512 }}</ref><ref name="pmid9718074">{{cite journal | vauthors = Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE | title = Hyperforin as a possible antidepressant component of hypericum extracts | journal = Life Sciences | volume = 63 | issue = 6 | pages = 499–510 | year = 1998 | pmid = 9718074 | doi = 10.1016/S0024-3205(98)00299-9 }}</ref> These compounds are [[reuptake inhibitor|inhibitor]]s of the [[reuptake]] of [[serotonin]], [[norepinephrine]], [[dopamine]], [[γ-aminobutyric acid]], and [[glutamate]], and they are reported to exert these [[drug action|effect]]s by [[binding (molecular)|binding]] to and [[receptor theory|activating]] TRPC6.<ref name="pmid9718074" /><ref name="pmid17666455">{{cite journal | vauthors = Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, Harteneck C, Müller WE | title = Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels | journal = FASEB Journal | volume = 21 | issue = 14 | pages = 4101–11 | date = December 2007 | pmid = 17666455 | doi = 10.1096/fj.07-8110com }}</ref> Recent results with hyperforin have cast doubt on these findings as similar currents are seen upon Hyperforin treatment regardless of the presence of TRPC6.<ref>{{cite journal | vauthors = Sell TS, Belkacemi T, Flockerzi V, Beck A | title = Protonophore properties of hyperforin are essential for its pharmacological activity | journal = Scientific Reports | volume = 4 | pages = 7500 | date = December 2014 | pmid = 25511254 | pmc = 4266863 | doi = 10.1038/srep07500 }}</ref>


==Further reading==
== References ==
{{refbegin | 2}}
{{reflist|33em}}
{{PBB_Further_reading
 
| citations =
== Further reading ==
*{{cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533-40 |year= 2004 |pmid= 12765698 |doi= }}
{{refbegin|33em}}
*{{cite journal | author=Walz G |title=Slit or pore? A mutation of the ion channel TRPC6 causes FSGS. |journal=Nephrol. Dial. Transplant. |volume=20 |issue= 9 |pages= 1777-9 |year= 2006 |pmid= 15998650 |doi= 10.1093/ndt/gfh961 }}
* {{cite journal | vauthors = Heiner I, Eisfeld J, Lückhoff A | title = Role and regulation of TRP channels in neutrophil granulocytes | journal = Cell Calcium | volume = 33 | issue = 5-6 | pages = 533–40 | year = 2004 | pmid = 12765698 | doi = 10.1016/S0143-4160(03)00058-7 }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
* {{cite journal | vauthors = Walz G | title = Slit or pore? A mutation of the ion channel TRPC6 causes FSGS | journal = Nephrology, Dialysis, Transplantation | volume = 20 | issue = 9 | pages = 1777–9 | date = September 2005 | pmid = 15998650 | doi = 10.1093/ndt/gfh961 }}
*{{cite journal | author=Schlöndorff JS, Pollak MR |title=TRPC6 in glomerular health and disease: what we know and what we believe. |journal=Semin. Cell Dev. Biol. |volume=17 |issue= 6 |pages= 667-74 |year= 2007 |pmid= 17116414 |doi= 10.1016/j.semcdb.2006.11.003 }}
* {{cite journal | vauthors = Clapham DE, Julius D, Montell C, Schultz G | title = International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 427–50 | date = December 2005 | pmid = 16382100 | doi = 10.1124/pr.57.4.6 }}
*{{cite journal | author=Dietrich A, Gudermann T |title=TRPC6. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 125-41 |year= 2007 |pmid= 17217054 |doi= 10.1007/978-3-540-34891-7_7 }}
* {{cite journal | vauthors = Schlöndorff JS, Pollak MR | title = TRPC6 in glomerular health and disease: what we know and what we believe | journal = Seminars in Cell & Developmental Biology | volume = 17 | issue = 6 | pages = 667–74 | date = December 2006 | pmid = 17116414 | pmc = 2705932 | doi = 10.1016/j.semcdb.2006.11.003 }}
}}
* {{cite journal | vauthors = Dietrich A, Gudermann T | title = TRPC6 | journal = Handbook of Experimental Pharmacology | volume = 179 | issue = 179 | pages = 125–41 | year = 2007 | pmid = 17217054 | doi = 10.1007/978-3-540-34891-7_7 | isbn = 978-3-540-34889-4 | series = Handbook of Experimental Pharmacology }}
{{refend}}
{{refend}}


== External links ==
* {{MeshName|TRPC6+protein,+human}}


==External links==
{{Ion channels|g4}}
*{{MeshName|TRPC6+protein,+human}}
{{Transient receptor potential channel modulators}}


[[Category:Membrane biology]]
[[Category:Ion channels]]


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{biochem-stub}}
{{Ion channels}}
[[Category:Membrane biology]]
[[Category:Ion channels]]
{{WikiDoc Sources}}

Latest revision as of 00:05, 1 May 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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UniProt

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RefSeq (mRNA)

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Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).[1]

Interactions

TRPC6 has been shown to interact with:

Ligands

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.[5][6] These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.[6][7] Recent results with hyperforin have cast doubt on these findings as similar currents are seen upon Hyperforin treatment regardless of the presence of TRPC6.[8]

References

  1. ↑ Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB (June 2005). "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science. 308 (5729): 1801–4. doi:10.1126/science.1106215. PMID 15879175.
  2. ↑ Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (April 2004). "Regulation of TRPC6 channel activity by tyrosine phosphorylation". The Journal of Biological Chemistry. 279 (18): 18887–94. doi:10.1074/jbc.M311274200. PMID 14761972.
  3. ↑ Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA (March 2004). "Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx". The Journal of Biological Chemistry. 279 (11): 10514–22. doi:10.1074/jbc.M308478200. PMID 14699131.
  4. ↑ Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305.
  5. ↑ Müller WE, Singer A, Wonnemann M (July 2001). "Hyperforin--antidepressant activity by a novel mechanism of action". Pharmacopsychiatry. 34 Suppl 1: S98–102. doi:10.1055/s-2001-15512. PMID 11518085.
  6. ↑ 6.0 6.1 Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sciences. 63 (6): 499–510. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074.
  7. ↑ Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, Harteneck C, Müller WE (December 2007). "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". FASEB Journal. 21 (14): 4101–11. doi:10.1096/fj.07-8110com. PMID 17666455.
  8. ↑ Sell TS, Belkacemi T, Flockerzi V, Beck A (December 2014). "Protonophore properties of hyperforin are essential for its pharmacological activity". Scientific Reports. 4: 7500. doi:10.1038/srep07500. PMC 4266863. PMID 25511254.

Further reading

External links

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