Stretch-activated ion channel
Though little is known about these channels, they may be linked to molecules in the cytoskeleton, which may open them by transmitting physical forces of stretch or pressure to the channels, causing them to undergo a conformational change. The channels may also be pulled open due to tension on the membrane itself. Opening the channels allows ions to which they are permeable to flow down their electrochemical gradients into or out of the cell, causing a change in membrane potential.
This can also be referred to as the Stress-activated gate because the gate (protein receptor) responds to pressure or stress.
- Mechanosensitive ion channel
- Large-conductance mechanosensitive channel
- Voltage-gated ion channels
- Ligand-gated ion channels
- Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science, 4th ed., Pages 113-114. McGraw-Hill, New York (2000). ISBN 0-8385-7701-6
- Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.
- Ozeki-Miyawaki C, Moriya Y, Tatsumi H, Iida H, Sokabe M (2005). "Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca2+ permeation". Exp. Cell Res. 311 (1): 84–95. doi:10.1016/j.yexcr.2005.08.014. PMID 16202999.
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