3D model (JSmol)
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|Molar mass||285.338 g/mol|
|Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds. Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.
Due to its effects on drug metabolism, piperine should be taken cautiously (if at all) by individuals taking other medications.
- Piperidine, a cyclic six-membered amine that results from hydrolysis of piperine
- Capsaicin, the active piquant chemical in chile peppers
- Allyl isothiocyanate, the active piquant chemical in mustard, radishes, horseradish and wasabi
- Allicin, the active piquant flavor chemical in uncooked garlic and onions (see those articles for discussion of other chemicals in them relating to pungency, and eye irritation)
- PMID 12130727
- PMID 3917507
- PMID 8347144
- PMID 9619120
- Merck Index, 11th Edition, 7442.
- MSDS for piperine
- PDRhealth.com - Piperine