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Amiloride-sensitive cation channel 2, neuronal
Symbol(s) ACCN2; ASIC; ASIC1A; BNaC2; hBNaC2
External IDs OMIM: 602866 MGI1194915 Homologene37440
RNA expression pattern

PBB GE ACCN2 37953 s at tn.png

PBB GE ACCN2 205156 s at tn.png

More reference expression data

Human Mouse
Entrez 41 11419
Ensembl ENSG00000110881 ENSMUSG00000023017
Uniprot na P97811
Refseq NM_001095 (mRNA)
NP_001086 (protein)
NM_009597 (mRNA)
NP_033727 (protein)
Location Chr 12: 48.74 - 48.76 Mb Chr 15: 99.5 - 99.53 Mb
Pubmed search [1] [2]

Amiloride-sensitive cation channel 2, neuronal, also known as ACCN2, is a human gene.[1]

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[1]


Further reading

  • Corey DP, García-Añoveros J (1996). "Mechanosensation and the DEG/ENaC ion channels.". Science. 273 (5273): 323–4. PMID 8685718. 
  • García-Añoveros J, Derfler B, Neville-Golden J; et al. (1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1459–64. PMID 9037075. 
  • Waldmann R, Champigny G, Bassilana F; et al. (1997). "A proton-gated cation channel involved in acid-sensing.". Nature. 386 (6621): 173–7. PMID 9062189. doi:10.1038/386173a0. 
  • Bassilana F, Champigny G, Waldmann R; et al. (1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.". J. Biol. Chem. 272 (46): 28819–22. PMID 9360943. 
  • Bubien JK, Keeton DA, Fuller CM; et al. (1999). "Malignant human gliomas express an amiloride-sensitive Na+ conductance.". Am. J. Physiol. 276 (6 Pt 1): C1405–10. PMID 10362604. 
  • Askwith CC, Cheng C, Ikuma M; et al. (2000). "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.". Neuron. 26 (1): 133–41. PMID 10798398. 
  • Bässler EL, Ngo-Anh TJ, Geisler HS; et al. (2001). "Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.". J. Biol. Chem. 276 (36): 33782–7. PMID 11448963. doi:10.1074/jbc.M104030200. 
  • Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). "Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells.". Pflugers Arch. 442 (5): 668–74. PMID 11512022. 
  • Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.". J. Biol. Chem. 277 (7): 5203–8. PMID 11739374. doi:10.1074/jbc.M104748200. 
  • Ji HL, Jovov B, Fu J; et al. (2002). "Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes.". J. Biol. Chem. 277 (10): 8395–405. PMID 11748227. doi:10.1074/jbc.M109465200. 
  • Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).". Biochem. J. 361 (Pt 3): 443–50. PMID 11802773. 
  • Wemmie JA, Chen J, Askwith CC; et al. (2002). "The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.". Neuron. 34 (3): 463–77. PMID 11988176. 
  • Berdiev BK, Xia J, Jovov B; et al. (2003). "Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function.". J. Biol. Chem. 277 (48): 45734–40. PMID 12244121. doi:10.1074/jbc.M208995200. 
  • Ugawa S, Ueda T, Ishida Y; et al. (2002). "Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.". J. Clin. Invest. 110 (8): 1185–90. PMID 12393854. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Leonard AS, Yermolaieva O, Hruska-Hageman A; et al. (2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. PMID 12578970. doi:10.1073/pnas.252782799. 
  • Wemmie JA, Coryell MW, Askwith CC; et al. (2004). "Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3621–6. PMID 14988500. doi:10.1073/pnas.0308753101. 
  • Poirot O, Vukicevic M, Boesch A, Kellenberger S (2004). "Selective regulation of acid-sensing ion channel 1 by serine proteases.". J. Biol. Chem. 279 (37): 38448–57. PMID 15247234. doi:10.1074/jbc.M407381200. 
  • Price MP, Thompson RJ, Eshcol JO; et al. (2005). "Stomatin modulates gating of acid-sensing ion channels.". J. Biol. Chem. 279 (51): 53886–91. PMID 15471860. doi:10.1074/jbc.M407708200.