TIE1: Difference between revisions
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'''Tyrosine kinase with immunoglobulin-like and EGF-like domains 1''' also known as '''TIE1''' is an [[angiopoietin receptor]] which in humans is encoded by the ''TIE1'' [[gene]].<ref name="pmid1312667">{{cite journal |vauthors=Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K | title = A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains | journal = | '''Tyrosine kinase with immunoglobulin-like and EGF-like domains 1''' also known as '''TIE1''' is an [[angiopoietin receptor]] which in humans is encoded by the ''TIE1'' [[gene]].<ref name="pmid1312667">{{cite journal | vauthors = Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K | title = A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains | journal = Molecular and Cellular Biology | volume = 12 | issue = 4 | pages = 1698–707 | date = April 1992 | pmid = 1312667 | pmc = 369613 | doi = | url = http://mcb.asm.org/cgi/content/abstract/12/4/1698 }}</ref> | ||
== Function == | == Function == | ||
TIE1 is a cell surface protein expressed exclusively in [[endothelium|endothelial]] cells, however it has also been shown to be expressed in immature [[hematopoietic cells]]<ref>{{cite journal| | TIE1 is a cell surface protein expressed exclusively in [[endothelium|endothelial]] cells, however it has also been shown to be expressed in immature [[hematopoietic cells]]<ref>{{cite journal | vauthors = Rodewald HR, Sato TN | title = Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells | journal = Oncogene | volume = 12 | issue = 2 | pages = 397–404 | date = January 1996 | pmid = 8570217 }}</ref> and platelets.<ref name="pmid11146396">{{cite journal | vauthors = Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP | title = Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets | journal = Journal of Vascular Research | volume = 37 | issue = 6 | pages = 437–42 | date = 2000 | pmid = 11146396 | doi = 10.1159/000054075 }}</ref> TIE1 upregulates the [[cell adhesion molecule]]s (CAMs) [[VCAM-1]], [[E-selectin]], and [[ICAM-1]] through a [[p38 mitogen-activated protein kinases|p38]]-dependent mechanism. Attachment of [[monocyte]] derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as [[atherosclerosis]].<ref name="pmid18448073">{{cite journal | vauthors = Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP | title = Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules | journal = Biochemical and Biophysical Research Communications | volume = 371 | issue = 3 | pages = 475–9 | date = July 2008 | pmid = 18448073 | doi = 10.1016/j.bbrc.2008.04.091 }}</ref> | ||
==See also== | == See also == | ||
* [[Angiopoietin#Tie_pathway]] | * [[Angiopoietin#Tie_pathway]] | ||
Latest revision as of 13:56, 23 June 2018
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |
|---|---|
| Identifiers | |
| Symbol | TIE1 |
| Alt. symbols | TIE, JTK14 |
| Entrez | 7075 |
| HUGO | 11809 |
| OMIM | 600222 |
| RefSeq | NM_005424 |
| UniProt | P35590 |
| Other data | |
| EC number | 2.7.1.112 |
| Locus | Chr. 1 p34-p33 |
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[1]
Function
TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[2] and platelets.[3] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[4]
See also
References
- ↑ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. PMC 369613. PMID 1312667.
- ↑ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.
- ↑ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396.
- ↑ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.
External links
- Receptor,+TIE-1 at the US National Library of Medicine Medical Subject Headings (MeSH)