Receptor tyrosine kinase-like orphan receptor

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Receptor tyrosine kinase-like orphan receptor
Identifiers
SymbolROR
InterProIPR016247
Membranome720
receptor tyrosine kinase-like orphan receptor 1
Identifiers
SymbolROR1
Alt. symbolsNTRKR1
Entrez4919
HUGO10256
OMIM602336
RefSeqNM_005012
UniProtQ01973
Other data
EC number2.7.10.1
LocusChr. 1 p32-p31
receptor tyrosine kinase-like orphan receptor 2
Identifiers
SymbolROR2
Alt. symbolsNTRKR2, BDB, BDB1
Entrez4920
HUGO10257
OMIM602337
RefSeqNM_004560
UniProtQ01974
Other data
LocusChr. 9 q22

In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR proteins (ROR1 and ROR2 in humans) can modulate Wnt signaling by sequestering Wnt ligands.[1]

References

  1. Green JL, Kuntz SG, Sternberg PW (November 2008). "Ror receptor tyrosine kinases: orphans no more". Trends Cell Biol. 18 (11): 536–44. doi:10.1016/j.tcb.2008.08.006. PMC 4672995. PMID 18848778.

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