KCNS3: Difference between revisions
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'''Potassium voltage-gated channel subfamily S member 3''' (Kv9.3) is a [[protein]] that in humans is encoded by the ''KCNS3'' [[gene]].<ref name="pmid10484328">{{cite journal | vauthors = Shepard AR, Rae JL | title = Electrically silent potassium channel subunits from human lens epithelium | journal = The American Journal of Physiology | volume = 277 | issue = 3 | pages = C412-24 | date = September 1999 | pmid = 10484328 | pmc = | doi = 10.1152/ajpcell.1999.277.3.C412 }}</ref><ref name="pmid16382104">{{cite journal | vauthors = Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 473–508 | date = December 2005 | pmid = 16382104 | pmc = | doi = 10.1124/pr.57.4.10 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3790| access-date = 19 June 2017}}</ref> KCNS3 gene belongs to the S subfamily of the potassium channel family.<ref name="entrez" /> It is highly expressed in [[pulmonary artery]] [[myocyte]]s,<ref name="Patel1997">{{cite journal | vauthors = Patel AJ, Lazdunski M, Honoré E | title = Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K<sup>+</sup> channel in oxygen-sensitive pulmonary artery myocytes | journal = The EMBO Journal | volume = 16 | issue = 22 | pages = 6615–25 | date = November 1997 | pmid = 9362476 | pmc = 1170266 | doi = 10.1093/emboj/16.22.6615 }}</ref><ref name="Stocker1998">{{cite journal | vauthors = Stocker M, Kerschensteiner D | title = Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain | journal = Biochemical and Biophysical Research Communications | volume = 248 | issue = 3 | pages = 927–34 | date = July 1998 | pmid = 9704029 | doi = 10.1006/bbrc.1998.9072 }}</ref><ref name="Fantozzi2006">{{cite journal | vauthors = Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX | title = Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K<sup>+</sup> channels in human pulmonary artery smooth muscle cells | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 291 | issue = 5 | pages = L993-1004 | date = November 2006 | pmid = 16815889 | doi = 10.1152/ajplung.00191.2005 }}</ref> [[placenta]],<ref name="Fyfe2012">{{cite journal | vauthors = Fyfe GK, Panicker S, Jones RL, Wareing M | title = Expression of an electrically silent voltage-gated potassium channel in the human placenta | journal = Journal of Obstetrics and Gynaecology | volume = 32 | issue = 7 | pages = 624–9 | date = October 2012 | pmid = 22943705 | doi = 10.3109/01443615.2012.709288 }}</ref> and [[parvalbumin]]-containing [[Gamma- | '''Potassium voltage-gated channel subfamily S member 3''' (Kv9.3) is a [[protein]] that in humans is encoded by the ''KCNS3'' [[gene]].<ref name="pmid10484328">{{cite journal | vauthors = Shepard AR, Rae JL | title = Electrically silent potassium channel subunits from human lens epithelium | journal = The American Journal of Physiology | volume = 277 | issue = 3 | pages = C412-24 | date = September 1999 | pmid = 10484328 | pmc = | doi = 10.1152/ajpcell.1999.277.3.C412 }}</ref><ref name="pmid16382104">{{cite journal | vauthors = Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 473–508 | date = December 2005 | pmid = 16382104 | pmc = | doi = 10.1124/pr.57.4.10 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3790| access-date = 19 June 2017}}</ref> KCNS3 gene belongs to the S subfamily of the potassium channel family.<ref name="entrez" /> It is highly expressed in [[pulmonary artery]] [[myocyte]]s,<ref name="Patel1997">{{cite journal | vauthors = Patel AJ, Lazdunski M, Honoré E | title = Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K<sup>+</sup> channel in oxygen-sensitive pulmonary artery myocytes | journal = The EMBO Journal | volume = 16 | issue = 22 | pages = 6615–25 | date = November 1997 | pmid = 9362476 | pmc = 1170266 | doi = 10.1093/emboj/16.22.6615 }}</ref><ref name="Stocker1998">{{cite journal | vauthors = Stocker M, Kerschensteiner D | title = Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain | journal = Biochemical and Biophysical Research Communications | volume = 248 | issue = 3 | pages = 927–34 | date = July 1998 | pmid = 9704029 | doi = 10.1006/bbrc.1998.9072 }}</ref><ref name="Fantozzi2006">{{cite journal | vauthors = Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX | title = Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K<sup>+</sup> channels in human pulmonary artery smooth muscle cells | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 291 | issue = 5 | pages = L993-1004 | date = November 2006 | pmid = 16815889 | doi = 10.1152/ajplung.00191.2005 }}</ref> [[placenta]],<ref name="Fyfe2012">{{cite journal | vauthors = Fyfe GK, Panicker S, Jones RL, Wareing M | title = Expression of an electrically silent voltage-gated potassium channel in the human placenta | journal = Journal of Obstetrics and Gynaecology | volume = 32 | issue = 7 | pages = 624–9 | date = October 2012 | pmid = 22943705 | doi = 10.3109/01443615.2012.709288 }}</ref> and [[parvalbumin]]-containing [[Gamma-Aminobutyric acid|GABA]] [[neuron]]s in [[brain cortex]].<ref name="Georgiev2012">{{cite journal | vauthors = Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T | title = Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex | journal = PLOS One | volume = 7 | issue = 8 | pages = e43904 | year = 2012 | pmid = 22937123 | doi = 10.1371/journal.pone.0043904 }}</ref><ref name="Georgiev2014">{{cite journal | vauthors = Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T | title = Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia | journal = The American Journal of Psychiatry | volume = 171 | issue = 1 | pages = 62–71 | date = January 2014 | pmid = 24170294 | doi = 10.1176/appi.ajp.2013.13040468 }}</ref> In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with [[airway hyperresponsiveness]],<ref name="Hao2005">{{cite journal | vauthors = Hao K, Niu T, Xu X, Fang Z, Xu X | title = Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness | journal = Human Genetics | volume = 116 | issue = 5 | pages = 378–83 | date = April 2005 | pmid = 15714333 | doi = 10.1007/s00439-005-1256-5 }}</ref> whereas decreased KCNS3 mRNA expression is found in the [[prefrontal cortex]] of patients with [[schizophrenia]].<ref name="Georgiev2014"/> | ||
== Function == | == Function == | ||
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== References == | == References == | ||
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[[Category:Ion channels]] | [[Category:Ion channels]] | ||
{{membrane-protein-stub}} | {{membrane-protein-stub}} | ||
Latest revision as of 18:27, 5 January 2019
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Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene.[1][2][3] KCNS3 gene belongs to the S subfamily of the potassium channel family.[3] It is highly expressed in pulmonary artery myocytes,[4][5][6] placenta,[7] and parvalbumin-containing GABA neurons in brain cortex.[8][9] In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness,[10] whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia.[9]
Function
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The Kv9.3 protein (encoded by KCNS3 gene) is not functional by itself[5] but can form functional heteromultimers with Kv2.1 (encoded by KCNB1) and Kv2.2 (encoded by KCNB2) (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins.[4] Heteromeric Kv2.1/Kv9.3 channels form with fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit.[11]
See also
References
- ↑ Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3): C412–24. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.
- ↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- ↑ 3.0 3.1 "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017.
- ↑ 4.0 4.1 Patel AJ, Lazdunski M, Honoré E (November 1997). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". The EMBO Journal. 16 (22): 6615–25. doi:10.1093/emboj/16.22.6615. PMC 1170266. PMID 9362476.
- ↑ 5.0 5.1 Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–34. doi:10.1006/bbrc.1998.9072. PMID 9704029.
- ↑ Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX (November 2006). "Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L993–1004. doi:10.1152/ajplung.00191.2005. PMID 16815889.
- ↑ Fyfe GK, Panicker S, Jones RL, Wareing M (October 2012). "Expression of an electrically silent voltage-gated potassium channel in the human placenta". Journal of Obstetrics and Gynaecology. 32 (7): 624–9. doi:10.3109/01443615.2012.709288. PMID 22943705.
- ↑ Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T (2012). "Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex". PLOS One. 7 (8): e43904. doi:10.1371/journal.pone.0043904. PMID 22937123.
- ↑ 9.0 9.1 Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T (January 2014). "Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia". The American Journal of Psychiatry. 171 (1): 62–71. doi:10.1176/appi.ajp.2013.13040468. PMID 24170294.
- ↑ Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–83. doi:10.1007/s00439-005-1256-5. PMID 15714333.
- ↑ Kerschensteiner D, Soto F, Stocker M (April 2005). "Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6160–6165. doi:10.1073/pnas.0500468102. PMC 1087924. PMID 15827117.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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