CCR3 (gene): Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
(→‎Function: Added content)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''C-C chemokine receptor type 3''' is a [[protein]] that in humans is encoded by the ''CCR3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CCR3 has also recently been designated '''CD193''' ([[cluster of differentiation]] 193).
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chemokine (C-C motif) receptor 3
| HGNCid = 1604
| Symbol = CCR3
| AltSymbols =; CC-CKR-3; CD193; CKR3; CMKBR3; MGC102841
| OMIM = 601268
| ECnumber = 
| Homologene = 20436
| MGIid = 104616
| GeneAtlas_image1 = PBB_GE_CCR3_208304_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1232
    | Hs_Ensembl = ENSG00000183625
    | Hs_RefseqProtein = NP_001828
    | Hs_RefseqmRNA = NM_001837
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 46227186
    | Hs_GenLoc_end = 46283103
    | Hs_Uniprot = P51677
    | Mm_EntrezGene = 12771
    | Mm_Ensembl = ENSMUSG00000035448
    | Mm_RefseqmRNA = NM_009914
    | Mm_RefseqProtein = NP_034044
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 123870898
    | Mm_GenLoc_end = 123879738
    | Mm_Uniprot = Q3U5L7
  }}
}}
'''Chemokine (C-C motif) receptor 3''', also known as '''CCR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}</ref>


CCR3 has also recently been designated '''CD193''' ([[cluster of differentiation]] 193).
== Function ==


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a receptor for C-C type [[chemokine]]s. It belongs to family 1 of the [[G protein-coupled receptor]]s. This receptor binds and responds to a variety of chemokines, including eotaxin ([[CCL11]]), eotaxin-3 ([[CCL26]]), MCP-3 ([[CCL7]]), MCP-4 ([[CCL13]]), and RANTES ([[CCL5]]). It is highly expressed in eosinophils and basophils,<ref>•Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.</ref> and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for [[HIV-1]]. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== Interactions ==
{{reflist|2}}
 
CCR3 (gene) has been shown to [[Protein-protein interaction|interact]] with [[CCL5]].<ref>{{cite journal | vauthors = Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR | title = Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils | journal = J. Exp. Med. | volume = 183 | issue = 6 | pages = 2437–48 | pmid = 8676064 | pmc = 2192612 | doi = 10.1084/jem.183.6.2437 }}</ref><ref name = pmid8642344>{{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | date = May 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 }}</ref><ref name = pmid11449371>{{cite journal | vauthors = Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J | title = Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils | journal = Eur. J. Immunol. | volume = 31 | issue = 7 | pages = 2170–8 | date = July 2001 | pmid = 11449371 | doi = 10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d }}</ref>
 
== References ==
{{reflist|30em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Choe H, Martin KA, Farzan M, Sodroski J, Gerard NP, Gerard C | title = Structural interactions between chemokine receptors, gp120 Env and CD4 | journal = Semin. Immunol. | volume = 10 | issue = 3 | pages = 249–57 | year = 1998 | pmid = 9653051 | doi = 10.1006/smim.1998.0127 }}
| citations =
* {{cite journal | vauthors = Marone G, Florio G, Petraroli A, de Paulis A | title = Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection | journal = J. Allergy Clin. Immunol. | volume = 107 | issue = 1 | pages = 22–30 | year = 2001 | pmid = 11149986 | doi = 10.1067/mai.2001.111589 }}
*{{cite journal | author=Choe H, Martin KA, Farzan M, ''et al.'' |title=Structural interactions between chemokine receptors, gp120 Env and CD4. |journal=Semin. Immunol. |volume=10 |issue= 3 |pages= 249-57 |year= 1998 |pmid= 9653051 |doi= }}
* {{cite journal | vauthors = Marone G, Florio G, Triggiani M, Petraroli A, de Paulis A | title = Mechanisms of IgE elevation in HIV-1 infection | journal = Crit. Rev. Immunol. | volume = 20 | issue = 6 | pages = 477–96 | year = 2001 | pmid = 11396683 | doi = 10.1615/critrevimmunol.v20.i6.40 }}
*{{cite journal | author=Marone G, Florio G, Petraroli A, de Paulis A |title=Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. |journal=J. Allergy Clin. Immunol. |volume=107 |issue= 1 |pages= 22-30 |year= 2001 |pmid= 11149986 |doi= }}
* {{cite journal | vauthors = Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM | title = HIV-1 infection and chemokine receptor modulation | journal = Curr. HIV Res. | volume = 2 | issue = 1 | pages = 39–50 | year = 2004 | pmid = 15053339 | doi = 10.2174/1570162043484997 }}
*{{cite journal | author=Marone G, Florio G, Triggiani M, ''et al.'' |title=Mechanisms of IgE elevation in HIV-1 infection. |journal=Crit. Rev. Immunol. |volume=20 |issue= 6 |pages= 477-96 |year= 2001 |pmid= 11396683 |doi= }}
* {{cite journal | vauthors = Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C | title = Molecular characterization of two murine eosinophil beta chemokine receptors | journal = J. Immunol. | volume = 155 | issue = 11 | pages = 5299–305 | year = 1995 | pmid = 7594543 | doi =  }}
*{{cite journal | author=Ruibal-Ares BH, Belmonte L, Baré PC, ''et al.'' |title=HIV-1 infection and chemokine receptor modulation. |journal=Curr. HIV Res. |volume=2 |issue= 1 |pages= 39-50 |year= 2004 |pmid= 15053339 |doi= }}
* {{cite journal | vauthors = Combadiere C, Ahuja SK, Murphy PM | title = Cloning and functional expression of a human eosinophil CC chemokine receptor | journal = J. Biol. Chem. | volume = 270 | issue = 28 | pages = 16491–4 | year = 1995 | pmid = 7622448 | doi = 10.1074/jbc.270.28.16491 }}
*{{cite journal | author=Post TW, Bozic CR, Rothenberg ME, ''et al.'' |title=Molecular characterization of two murine eosinophil beta chemokine receptors. |journal=J. Immunol. |volume=155 |issue= 11 |pages= 5299-305 |year= 1995 |pmid= 7594543 |doi=  }}
* {{cite journal | vauthors = Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR | title = Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils | journal = J. Clin. Invest. | volume = 97 | issue = 3 | pages = 604–12 | year = 1996 | pmid = 8609214 | pmc = 507095 | doi = 10.1172/JCI118456 }}
*{{cite journal | author=Combadiere C, Ahuja SK, Murphy PM |title=Cloning and functional expression of a human eosinophil CC chemokine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 28 |pages= 16491-4 |year= 1995 |pmid= 7622448 |doi= }}
* {{cite journal | vauthors = Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O | title = Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 | journal = J. Biol. Chem. | volume = 271 | issue = 13 | pages = 7725–30 | year = 1996 | pmid = 8631813 | doi = 10.1074/jbc.271.13.7725 }}
*{{cite journal | author=Ponath PD, Qin S, Ringler DJ, ''et al.'' |title=Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. |journal=J. Clin. Invest. |volume=97 |issue= 3 |pages= 604-12 |year= 1996 |pmid= 8609214 |doi= }}
* {{cite journal | vauthors = Combadiere C, Ahuja SK, Murphy PM | title = Cloning and functional expression of a human eosinophil CC chemokine receptor | journal = J. Biol. Chem. | volume = 271 | issue = 18 | pages = 11034 | year = 1996 | pmid = 8631926 | doi =  }}
*{{cite journal | author=Kitaura M, Nakajima T, Imai T, ''et al.'' |title=Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7725-30 |year= 1996 |pmid= 8631813 |doi= }}
* {{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | year = 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 }}
*{{cite journal | author=Combadiere C, Ahuja SK, Murphy PM |title=Cloning and functional expression of a human eosinophil CC chemokine receptor. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 11034 |year= 1996 |pmid= 8631926 |doi=  }}
* {{cite journal | vauthors = Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J | title = The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates | journal = Cell | volume = 85 | issue = 7 | pages = 1135–48 | year = 1996 | pmid = 8674119 | doi = 10.1016/S0092-8674(00)81313-6 }}
*{{cite journal | author=Daugherty BL, Siciliano SJ, DeMartino JA, ''et al.'' |title=Cloning, expression, and characterization of the human eosinophil eotaxin receptor. |journal=J. Exp. Med. |volume=183 |issue= 5 |pages= 2349-54 |year= 1996 |pmid= 8642344 |doi= }}
* {{cite journal | vauthors = Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR | title = Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils | journal = J. Exp. Med. | volume = 183 | issue = 6 | pages = 2437–48 | year = 1996 | pmid = 8676064 | pmc = 2192612 | doi = 10.1084/jem.183.6.2437 }}
*{{cite journal | author=Choe H, Farzan M, Sun Y, ''et al.'' |title=The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. |journal=Cell |volume=85 |issue= 7 |pages= 1135-48 |year= 1996 |pmid= 8674119 |doi= }}
* {{cite journal | vauthors = Samson M, Soularue P, Vassart G, Parmentier M | title = The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3 | journal = Genomics | volume = 36 | issue = 3 | pages = 522–6 | year = 1997 | pmid = 8884276 | doi = 10.1006/geno.1996.0498 }}
*{{cite journal | author=Ponath PD, Qin S, Post TW, ''et al.'' |title=Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. |journal=J. Exp. Med. |volume=183 |issue= 6 |pages= 2437-48 |year= 1996 |pmid= 8676064 |doi= }}
* {{cite journal | vauthors = Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR | title = Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody | journal = J. Clin. Invest. | volume = 99 | issue = 2 | pages = 178–84 | year = 1997 | pmid = 9005985 | pmc = 507784 | doi = 10.1172/JCI119145 }}
*{{cite journal | author=Samson M, Soularue P, Vassart G, Parmentier M |title=The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. |journal=Genomics |volume=36 |issue= 3 |pages= 522-6 |year= 1997 |pmid= 8884276 |doi= 10.1006/geno.1996.0498 }}
* {{cite journal | vauthors = He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D | title = CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia | journal = Nature | volume = 385 | issue = 6617 | pages = 645–9 | year = 1997 | pmid = 9024664 | doi = 10.1038/385645a0 }}
*{{cite journal | author=Heath H, Qin S, Rao P, ''et al.'' |title=Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. |journal=J. Clin. Invest. |volume=99 |issue= 2 |pages= 178-84 |year= 1997 |pmid= 9005985 |doi= }}
* {{cite journal | vauthors = Daugherty BL, Springer MS | title = The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21 | journal = Genomics | volume = 41 | issue = 2 | pages = 294–5 | year = 1997 | pmid = 9143512 | doi = 10.1006/geno.1997.4626 }}
*{{cite journal | author=He J, Chen Y, Farzan M, ''et al.'' |title=CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. |journal=Nature |volume=385 |issue= 6617 |pages= 645-9 |year= 1997 |pmid= 9024664 |doi= 10.1038/385645a0 }}
* {{cite journal | vauthors = Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M | title = Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes | journal = J. Exp. Med. | volume = 185 | issue = 12 | pages = 2171–6 | year = 1997 | pmid = 9182688 | pmc = 2196360 | doi = 10.1084/jem.185.12.2171 }}
*{{cite journal | author=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294-5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626 }}
* {{cite journal | vauthors = Alkhatib G, Berger EA, Murphy PM, Pease JE | title = Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions | journal = J. Biol. Chem. | volume = 272 | issue = 33 | pages = 20420–6 | year = 1997 | pmid = 9252350 | doi = 10.1074/jbc.272.33.20420 }}
*{{cite journal | author=Forssmann U, Uguccioni M, Loetscher P, ''et al.'' |title=Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. |journal=J. Exp. Med. |volume=185 |issue= 12 |pages= 2171-6 |year= 1997 |pmid= 9182688 |doi= }}
* {{cite journal | vauthors = Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA | title = Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5 | journal = Biochemistry | volume = 36 | issue = 32 | pages = 9642–8 | year = 1997 | pmid = 9289016 | doi = 10.1021/bi970593z }}
*{{cite journal | author=Alkhatib G, Berger EA, Murphy PM, Pease JE |title=Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20420-6 |year= 1997 |pmid= 9252350 |doi= }}
* {{cite journal | vauthors = Sallusto F, Mackay CR, Lanzavecchia A | title = Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells | journal = Science | volume = 277 | issue = 5334 | pages = 2005–7 | year = 1997 | pmid = 9302298 | doi = 10.1126/science.277.5334.2005 }}
*{{cite journal | author=Pakianathan DR, Kuta EG, Artis DR, ''et al.'' |title=Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5. |journal=Biochemistry |volume=36 |issue= 32 |pages= 9642-8 |year= 1997 |pmid= 9289016 |doi= 10.1021/bi970593z }}
*{{cite journal | author=Sallusto F, Mackay CR, Lanzavecchia A |title=Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. |journal=Science |volume=277 |issue= 5334 |pages= 2005-7 |year= 1997 |pmid= 9302298 |doi= }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2224 | title = Chemokine Receptors: CCR3  | accessdate = | author = | authorlink = | coauthors = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{MeshName|CCR3+protein,+human}}
* {{MeshName|CCR3+protein,+human}}
* {{UCSC gene info|CCR3}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Chemokine receptors}}
{{Cytokine receptors}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Chemokine receptor modulators}}
{{DEFAULTSORT:Ccr3 (Gene)}}
[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 23:59, 16 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.[1]

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,[2] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.[1]

See also

Interactions

CCR3 (gene) has been shown to interact with CCL5.[3][4][5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CCR3 chemokine (C-C motif) receptor 3".
  2. ↑ •Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.
  3. ↑ Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR. "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
  4. ↑ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
  5. ↑ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d. PMID 11449371.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Retrieved from "https://www.wikidoc.org/index.php?title=CCR3_(gene)&oldid=1541739"