EDG8
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| Endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | EDG8 ; Edg-8; S1P5; S1PR5; SPPR-1; SPPR-2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 11031 | ||||||||||
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| Species | Human | Mouse | |||||||||
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EDG8 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[1]
See also
References
Further reading
- Im DS, Heise CE, Ancellin N; et al. (2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". J. Biol. Chem. 275 (19): 14281–6. PMID 10799507.
- Malek RL, Toman RE, Edsall LC; et al. (2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". J. Biol. Chem. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896.
- Hla T. "Sphingosine 1-phosphate receptors". 64 (1–4): 135–142. PMID 11331101.
- Im DS, Clemens J, Macdonald TL, Lynch KR (2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry. 40 (46): 14053–60. PMID 11705398.
- Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. PMID 12044878.
- Niedernberg A, Scherer CR, Busch AE, Kostenis E (2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochem. Pharmacol. 64 (8): 1243–50. PMID 12234605.
- Kothapalli R, Kusmartseva I, Loughran TP (2003). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochim. Biophys. Acta. 1579 (2–3): 117–23. PMID 12427546.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vogler R, Sauer B, Kim DS; et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochem. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
External links
- IUPHAR GPCR Database - Lysophospholipid receptors
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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