Carmofur

Jump to: navigation, search
Carmofur
Carmofur Wiki Str.png
Clinical data
Synonyms1-hexylcarbamoyl-5-fluorouracil
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC11H16FN3O3
Molar mass257.261 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Carmofur

Articles

Most recent articles on Carmofur

Most cited articles on Carmofur

Review articles on Carmofur

Articles on Carmofur in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Carmofur

Images of Carmofur

Photos of Carmofur

Podcasts & MP3s on Carmofur

Videos on Carmofur

Evidence Based Medicine

Cochrane Collaboration on Carmofur

Bandolier on Carmofur

TRIP on Carmofur

Clinical Trials

Ongoing Trials on Carmofur at Clinical Trials.gov

Trial results on Carmofur

Clinical Trials on Carmofur at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Carmofur

NICE Guidance on Carmofur

NHS PRODIGY Guidance

FDA on Carmofur

CDC on Carmofur

Books

Books on Carmofur

News

Carmofur in the news

Be alerted to news on Carmofur

News trends on Carmofur

Commentary

Blogs on Carmofur

Definitions

Definitions of Carmofur

Patient Resources / Community

Patient resources on Carmofur

Discussion groups on Carmofur

Patient Handouts on Carmofur

Directions to Hospitals Treating Carmofur

Risk calculators and risk factors for Carmofur

Healthcare Provider Resources

Symptoms of Carmofur

Causes & Risk Factors for Carmofur

Diagnostic studies for Carmofur

Treatment of Carmofur

Continuing Medical Education (CME)

CME Programs on Carmofur

International

Carmofur en Espanol

Carmofur en Francais

Business

Carmofur in the Marketplace

Patents on Carmofur

Experimental / Informatics

List of terms related to Carmofur

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.

Uses

Breast Cancer

Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.[1]

Adverse effects

As fluorouracil, carmofur has been known to induce leukoencephalopathy.[2][3][4]

References

  1. Sakamoto, J; Hamada, C; Rahman, M; Kodaira, S; Ito, K; Nakazato, H; Ohashi, Y; Yasutomi, M (2005). "An Individual Patient Data Meta-analysis of Adjuvant Therapy with Carmofur in Patients with Curatively Resected Colon Cancer". Japanese Journal of Clinical Oncology. 35 (9): 536–544. doi:10.1093/jjco/hyi147. PMID 16155120.
  2. Yamada T, Okamura S, Okazaki T; et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature". Asia Oceania J Obstet Gynaecol. 15 (2): 161–8. PMID 2667512.
  3. Mizutani T (February 2008). "[Leukoencephalopathy caused by antineoplastic drugs]". Brain Nerve (in Japanese). 60 (2): 137–41. PMID 18306661.
  4. Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients". J Neurol Neurosurg Psychiatr. 79 (5): 535–9. doi:10.1136/jnnp.2007.123737. PMID 17682013.

Linked-in.jpg