Adenosine A2b receptor

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The correct title of this article is Adenosine A2b receptor. It appears incorrectly here because of technical restrictions.

Adenosine A2b receptor
Symbol(s) ADORA2B; ADORA2
External IDs OMIM: 600446 MGI99403 Homologene20167
RNA expression pattern

PBB GE ADORA2B 205891 at tn.png

More reference expression data

Human Mouse
Entrez 136 11541
Ensembl ENSG00000170425 na
Uniprot P29275 na
Refseq NM_000676 (mRNA)
NP_000667 (protein)
XM_906642 (mRNA)
XP_911735 (protein)
Location Chr 17: 15.79 - 15.82 Mb na
Pubmed search [1] [2]

The adenosine A2b receptor, also known as ADORA2B, is an adenosine receptor, and also denotes the human gene incoding it.[1]


This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.


The gene is located near the Smith-Magenis syndrome region on chromosome 17.[1]


Further reading

  • Stiles GL (1992). "Adenosine receptors.". J. Biol. Chem. 267 (10): 6451–4. PMID 1551861. 
  • Pierce KD, Furlong TJ, Selbie LA, Shine J (1992). "Molecular cloning and expression of an adenosine A2b receptor from human brain.". Biochem. Biophys. Res. Commun. 187 (1): 86–93. PMID 1325798. 
  • Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA (1995). "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.". Genomics. 27 (2): 374–6. PMID 7558011. doi:10.1006/geno.1995.1061. 
  • Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR (1995). "Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids.". Genomics. 25 (2): 605–7. PMID 7790006. 
  • Strohmeier GR, Reppert SM, Lencer WI, Madara JL (1995). "The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.". J. Biol. Chem. 270 (5): 2387–94. PMID 7836474. 
  • Feoktistov I, Murray JJ, Biaggioni I (1994). "Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.". Mol. Pharmacol. 45 (6): 1160–7. PMID 8022409. 
  • Mirabet M, Herrera C, Cordero OJ; et al. (1999). "Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation.". J. Cell. Sci. 112 ( Pt 4): 491–502. PMID 9914161. 
  • Feoktistov I, Goldstein AE, Biaggioni I (1999). "Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.". Mol. Pharmacol. 55 (4): 726–34. PMID 10101031. 
  • Corset V, Nguyen-Ba-Charvet KT, Forcet C; et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.". Nature. 407 (6805): 747–50. PMID 11048721. doi:10.1038/35037600. 
  • Herrera C, Casadó V, Ciruela F; et al. (2001). "Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells.". Mol. Pharmacol. 59 (1): 127–34. PMID 11125033. 
  • Christofi FL, Zhang H, Yu JG; et al. (2001). "Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.". J. Comp. Neurol. 439 (1): 46–64. PMID 11579381. doi:10.1002/cne.1334. 
  • Hayallah AM, Sandoval-Ramírez J, Reith U; et al. (2002). "1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.". J. Med. Chem. 45 (7): 1500–10. PMID 11906291. 
  • Sitaraman SV, Wang L, Wong M; et al. (2002). "The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.". J. Biol. Chem. 277 (36): 33188–95. PMID 12080047. doi:10.1074/jbc.M202522200. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I (2003). "Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.". Circ. Res. 92 (5): 485–92. PMID 12600879. doi:10.1161/01.RES.0000061572.10929.2D. 
  • Eltzschig HK, Ibla JC, Furuta GT; et al. (2003). "Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.". J. Exp. Med. 198 (5): 783–96. PMID 12939345. doi:10.1084/jem.20030891. 
  • Ryzhov S, Goldstein AE, Matafonov A; et al. (2004). "Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.". J. Immunol. 172 (12): 7726–33. PMID 15187156. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Kolachala V, Asamoah V, Wang L; et al. (2005). "Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase.". J. Biol. Chem. 280 (6): 4048–57. PMID 15550390. doi:10.1074/jbc.M409577200.