Non small cell lung cancer causes: Difference between revisions

Jump to navigation Jump to search
(Created page with "__NOTOC__ {{Non small cell lung cancer}} {{PleaseHelp}} ==References== {{reflist|2}} Category:Hematology Category:Types of cancer Category:Oncology Category:Ne...")
 
No edit summary
 
(16 intermediate revisions by 6 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Non small cell lung cancer}}
{{Non small cell lung cancer}}
{{PleaseHelp}}
{{CMG}}; {{AE}}{{Trusha}},{{MV}}
 
==Overview==
 
Cancers are caused by [[DNA]] changes that turn on [[Oncogene|oncogenes]] or turn off [[Tumor suppressor gene|tumor suppressor genes]]. [[Mutation|DNA mutations]] can be acquired or [[Heredity|hereditary]]. Non-small cell lung cancer may develop by [[Acquired disorder|acquired]] [[Mutation|genetic mutation]] of the ''[[TP53]]'' or [[P16 (gene)|''p16'' tumor suppressor genes]] and the ''[[KRAS|K-RAS]]'' or ''[[ALK-positive ALCL|ALK]]'' oncogenes as result of exposure to environmental factors such as [[smoking]], [[asbestos]] exposure, [[ionizing radiation]], and [[air pollution]], which are considered as [[Non small cell lung cancer risk factors|risk factors for NSCLC]]. [[Heredity|Hereditary]] factors in development of [[lung cancer]] is poorly understood because they are masked by the influence of environmental factors.
 
==Causes==
Non-small cell lung cancer is caused by [[DNA mutations]] as a result of exposure to environmental [[Non small cell lung cancer risk factors|risk factors]].<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
*Genes involved in the pathogenesis of non small cell cancer of the lung include:<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref><ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref><ref name="pmid20139701">{{cite journal |vauthors=Varella-Garcia M |title=Chromosomal and genomic changes in lung cancer |journal=Cell Adh Migr |volume=4 |issue=1 |pages=100–6 |date=2010 |pmid=20139701 |pmc=2852566 |doi= |url=}}</ref>
**[[epidermal growth factor receptor|Activation of EGFR (7p11)]]
**[[KRAS|KRAS (12p12) mutation]]
**[[BRAF]] (7q34)
**[[HER2]]<ref name="pmid24317180">{{cite journal |vauthors=Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S |title=Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas |journal=J. Natl. Cancer Inst. |volume=106 |issue=1 |pages=djt338 |date=January 2014 |pmid=24317180 |pmc=3906987 |doi=10.1093/jnci/djt338 |url=}}</ref>
**PIK3CA (3q26)<ref name="pmid25473901">{{cite journal |vauthors=Scheffler M, Bos M, Gardizi M, König K, Michels S, Fassunke J, Heydt C, Künstlinger H, Ihle M, Ueckeroth F, Albus K, Serke M, Gerigk U, Schulte W, Töpelt K, Nogova L, Zander T, Engel-Riedel W, Stoelben E, Ko YD, Randerath W, Kaminsky B, Panse J, Becker C, Hellmich M, Merkelbach-Bruse S, Heukamp LC, Büttner R, Wolf J |title=PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies |journal=Oncotarget |volume=6 |issue=2 |pages=1315–26 |date=January 2015 |pmid=25473901 |pmc=4359235 |doi=10.18632/oncotarget.2834 |url=}}</ref>
**[[ERBB2IP|ERBB2]] (17q12)
**Fusion between [[EML4]] and [[anaplastic lymphoma kinase|ALK]]<ref name="pmid17625570">{{cite journal| author=Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al.| title=Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. | journal=Nature | year= 2007 | volume= 448 | issue= 7153 | pages= 561-6 | pmid=17625570 | doi=10.1038/nature05945 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17625570  }}</ref>
**[[Tyrosine kinase|Tyrosine kinase fusions]]
**[[ALK(+)-ALCL|ALK (2p23)]]
**[[ROS1 (gene)|ROS1]] (6q22) alteration<ref name="pmid22919003">{{cite journal| author=Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM et al.| title=Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. | journal=Clin Cancer Res | year= 2012 | volume= 18 | issue= 17 | pages= 4570-9 | pmid=22919003 | doi=10.1158/1078-0432.CCR-12-0550 | pmc=PMC3703205 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22919003  }}</ref>
**[[RET proto-oncogene|RET]] (10q11)


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Needs content]]
[[Category:Disease]]
[[Category:Disease]]


{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Pulmonology]]
[[Category:Surgery]]

Latest revision as of 17:49, 28 January 2019

Non Small Cell Lung Cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Non Small Cell Lung Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-Ray

CT Scan

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Management Approach

Stage I
Stage II
Stage III
Stage IV
Metastatic Cancer

Medical Therapy

Chemotherapy
Radiation Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Non small cell lung cancer causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Non small cell lung cancer causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Non small cell lung cancer causes

CDC on Non small cell lung cancer causes

Non small cell lung cancer causes in the news

Blogs on Non small cell lung cancer causes

Directions to Hospitals Treating Non small cell carcinoma of the lung

Risk calculators and risk factors for Non small cell lung cancer causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2],Maria Fernanda Villarreal, M.D. [3]

Overview

Cancers are caused by DNA changes that turn on oncogenes or turn off tumor suppressor genes. DNA mutations can be acquired or hereditary. Non-small cell lung cancer may develop by acquired genetic mutation of the TP53 or p16 tumor suppressor genes and the K-RAS or ALK oncogenes as result of exposure to environmental factors such as smoking, asbestos exposure, ionizing radiation, and air pollution, which are considered as risk factors for NSCLC. Hereditary factors in development of lung cancer is poorly understood because they are masked by the influence of environmental factors.

Causes

Non-small cell lung cancer is caused by DNA mutations as a result of exposure to environmental risk factors.[1]

References

  1. National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015
  2. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  3. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  4. Varella-Garcia M (2010). "Chromosomal and genomic changes in lung cancer". Cell Adh Migr. 4 (1): 100–6. PMC 2852566. PMID 20139701.
  5. Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S (January 2014). "Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas". J. Natl. Cancer Inst. 106 (1): djt338. doi:10.1093/jnci/djt338. PMC 3906987. PMID 24317180.
  6. Scheffler M, Bos M, Gardizi M, König K, Michels S, Fassunke J, Heydt C, Künstlinger H, Ihle M, Ueckeroth F, Albus K, Serke M, Gerigk U, Schulte W, Töpelt K, Nogova L, Zander T, Engel-Riedel W, Stoelben E, Ko YD, Randerath W, Kaminsky B, Panse J, Becker C, Hellmich M, Merkelbach-Bruse S, Heukamp LC, Büttner R, Wolf J (January 2015). "PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies". Oncotarget. 6 (2): 1315–26. doi:10.18632/oncotarget.2834. PMC 4359235. PMID 25473901.
  7. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). "Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer". Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.
  8. Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM; et al. (2012). "Identifying and targeting ROS1 gene fusions in non-small cell lung cancer". Clin Cancer Res. 18 (17): 4570–9. doi:10.1158/1078-0432.CCR-12-0550. PMC 3703205. PMID 22919003.


Template:WikiDoc Sources