ERBB2IP

Erbb2 interacting protein
PDB rendering based on 1mfg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mfg​, 1mfl​, 1n7t​, 2h3l​
Identifiers
Symbols	ERBB2IP ; LAP2; ERBIN
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41282
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Erbb2 interacting protein, also known as ERBB2IP, is a human gene.

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolch W (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE. 2003 (199): pe37. doi:10.1126/stke.2003.199.pe37. PMID 12966186.
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borg JP, Marchetto S, Le Bivic A; et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell Biol. 2 (7): 407–14. doi:10.1038/35017038. PMID 10878805.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaulin-Bastard F, Saito H, Le Bivic A; et al. (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang YZ, Wang Q, Xiong WC, Mei L (2001). "Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95". J. Biol. Chem. 276 (22): 19318–26. doi:10.1074/jbc.M100494200. PMID 11279080.CS1 maint: Multiple names: authors list (link)
• Favre B, Fontao L, Koster J; et al. (2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. 276 (35): 32427–36. doi:10.1074/jbc.M011005200. PMID 11375975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito H, Santoni MJ, Arsanto JP; et al. (2001). "Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells". J. Biol. Chem. 276 (34): 32051–5. doi:10.1074/jbc.C100330200. PMID 11440998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaulin-Bastard F, Arsanto JP, Le Bivic A; et al. (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laura RP, Witt AS, Held HA; et al. (2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izawa I, Nishizawa M, Tomono Y; et al. (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. PMID 12047349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohno H, Hirabayashi S, Iizuka T; et al. (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang YZ, Zang M, Xiong WC; et al. (2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): 1108–14. doi:10.1074/jbc.M205413200. PMID 12379659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birrane G, Chung J, Ladias JA (2003). "Novel mode of ligand recognition by the Erbin PDZ domain". J. Biol. Chem. 278 (3): 1399–402. doi:10.1074/jbc.C200571200. PMID 12444095.CS1 maint: Multiple names: authors list (link)
• Skelton NJ, Koehler MF, Zobel K; et al. (2003). "Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain". J. Biol. Chem. 278 (9): 7645–54. doi:10.1074/jbc.M209751200. PMID 12446668.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. PMID 12650946.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)