Multiple endocrine neoplasia type 2 differential diagnosis: Difference between revisions
No edit summary |
No edit summary |
||
Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Multiple endocrine neoplasia type 2 must be differentiated from medullary thyroid carcinoma, C-cell hyperplasia, pheochromocytoma, von Hippel Lindau syndrome, hereditary paraganglioma-pheochromocytoma, polycythemia and paraganglioma/pheochromocytoma syndrome, neurofibromatosis type 1 and multiple endocrine neoplasia type 1 (MEN 1). | Multiple endocrine neoplasia type 2 must be differentiated from [[medullary thyroid carcinoma]], [[C-cell hyperplasia]], [[pheochromocytoma]], [[von Hippel Lindau syndrome]], [[hereditary paraganglioma-pheochromocytoma]], [[polycythemia and paraganglioma/pheochromocytoma syndrome]], [[neurofibromatosis type 1]] and [[multiple endocrine neoplasia type 1]] (MEN 1). | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Multiple endocrine neoplasia type 2 must be differentiated from following hereditary diseases. | Multiple endocrine neoplasia type 2 must be differentiated from following hereditary diseases. | ||
Line 13: | Line 13: | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Medullary thyroid carcinoma]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Medullary thyroid carcinoma]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Medullary thyroid cancer (MTC) is a form of thyroid carcinoma which originates from the parafollicular | | style="padding: 5px 5px; background: #F5F5F5;" |[[Medullary thyroid cancer]] (MTC) is a form of [[thyroid carcinoma]] which originates from the [[parafollicular cell]]s (C cells), which produce the [[hormone]] [[calcitonin]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[C-cell hyperplasia]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[C-cell hyperplasia]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |It is a genetic condition that causes proliferation of C | | style="padding: 5px 5px; background: #F5F5F5;" |It is a genetic condition that causes proliferation of [[C cell]]s of [[parathyroid gland]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Pheochromocytoma]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Pheochromocytoma]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" | A neuroendocrine tumor of the medulla of the adrenal | | style="padding: 5px 5px; background: #F5F5F5;" | A [[neuroendocrine tumor]] of the [[medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s), or extra-adrenal [[chromaffin]] [[tissue]] that failed to involute after birth | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[VHL (von Hippel Lindau) syndrome]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[VHL (von Hippel Lindau) syndrome]] | ||
Line 25: | Line 25: | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Hereditary paraganglioma-pheochromocytoma syndrome]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Hereditary paraganglioma-pheochromocytoma syndrome]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |A genetic disorder causing abnormal growth of | | style="padding: 5px 5px; background: #F5F5F5;" |A genetic disorder causing abnormal growth of [[ganglion]]s along with [[tumor]] of the [[medulla]] of [[adrenal gland]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Polycythemia and paraganglioma/pheochromocytoma]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Polycythemia and paraganglioma/pheochromocytoma]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |A genetic disorder causing abnormal growth of [[ganglion]]s and RBC | | style="padding: 5px 5px; background: #F5F5F5;" |A genetic disorder causing abnormal growth of [[ganglion]]s and [[RBC cell]]s. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Neurofibromatosis type 1]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Neurofibromatosis type 1]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Neurofibromatosis type I is a tumor disorder that is caused by the mutation of a gene on chromosome 17 that is responsible for control of cell division causing | | style="padding: 5px 5px; background: #F5F5F5;" |[[Neurofibromatosis type I]] is a [[tumor]] disorder that is caused by the [[mutation]] of a [[gene]] on [[chromosome 17]] that is responsible for control of [[cell]] division causing [[tumor]]s along the [[nervous system]]. Common symptoms of [[neurofibromatosis type I]] include [[scoliosis]] (curvature of the [[spine]]), learning disabilities, [[vision]] disorders, and [[epilepsy]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Multiple endocrine neoplasia type 1 (MEN 1)]] | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Multiple endocrine neoplasia type 1 (MEN 1)]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |An [[autosomal dominant]] genetic disorder causing | | style="padding: 5px 5px; background: #F5F5F5;" |An [[autosomal dominant]] genetic disorder causing [[tumor]]s of [[parathyroid]], [[pancreas]] and [[pituitary gland]]. | ||
|} | |} | ||
==References== | ==References== |
Revision as of 16:30, 28 September 2015
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
---|
Diagnosis |
Treatment |
Multiple endocrine neoplasia type 2 differential diagnosis On the Web |
American Roentgen Ray Society Images of Multiple endocrine neoplasia type 2 differential diagnosis |
FDA on Multiple endocrine neoplasia type 2 differential diagnosis |
CDC on Multiple endocrine neoplasia type 2 differential diagnosis |
Multiple endocrine neoplasia type 2 differential diagnosis in the news |
Blogs on Multiple endocrine neoplasia type 2 differential diagnosis |
Directions to Hospitals Treating Multiple endocrine neoplasia type 2 |
Risk calculators and risk factors for Multiple endocrine neoplasia type 2 differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Multiple endocrine neoplasia type 2 must be differentiated from medullary thyroid carcinoma, C-cell hyperplasia, pheochromocytoma, von Hippel Lindau syndrome, hereditary paraganglioma-pheochromocytoma, polycythemia and paraganglioma/pheochromocytoma syndrome, neurofibromatosis type 1 and multiple endocrine neoplasia type 1 (MEN 1).
Differential Diagnosis
Multiple endocrine neoplasia type 2 must be differentiated from following hereditary diseases.
Disease | Definition |
---|---|
Medullary thyroid carcinoma | Medullary thyroid cancer (MTC) is a form of thyroid carcinoma which originates from the parafollicular cells (C cells), which produce the hormone calcitonin. |
C-cell hyperplasia | It is a genetic condition that causes proliferation of C cells of parathyroid gland. |
Pheochromocytoma | A neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after birth |
VHL (von Hippel Lindau) syndrome | An autosomal dominant genetic disorder causing abnormal growth of blood vessels in different parts of the body. |
Hereditary paraganglioma-pheochromocytoma syndrome | A genetic disorder causing abnormal growth of ganglions along with tumor of the medulla of adrenal gland. |
Polycythemia and paraganglioma/pheochromocytoma | A genetic disorder causing abnormal growth of ganglions and RBC cells. |
Neurofibromatosis type 1 | Neurofibromatosis type I is a tumor disorder that is caused by the mutation of a gene on chromosome 17 that is responsible for control of cell division causing tumors along the nervous system. Common symptoms of neurofibromatosis type I include scoliosis (curvature of the spine), learning disabilities, vision disorders, and epilepsy. |
Multiple endocrine neoplasia type 1 (MEN 1) | An autosomal dominant genetic disorder causing tumors of parathyroid, pancreas and pituitary gland. |