Mequitazine: Difference between revisions

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{{drugbox
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 407774264
| IUPAC_name = 10-(4-azabicyclo[2.2.2] oct-7-ylmethyl) phenothiazine
| IUPAC_name = 10-(4-azabicyclo[2.2.2] oct-7-ylmethyl) phenothiazine
| image = Mequitazine.svg
| image = Mequitazine.png
 
<!--Clinical data-->
| tradename = Primalan
| Drugs.com = {{drugs.com|international|mequitazine}}
| pregnancy_category = 
| legal_status = 
| routes_of_administration = 
 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
 
<!--Identifiers-->
| CASNo_Ref = {{cascite}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 29216-28-2
| CAS_number = 29216-28-2
| ATC_prefix = R06
| ATC_prefix = R06
| ATC_suffix = AD07
| ATC_suffix = AD07
| ATC_supplemental =
| PubChem = 4066
| PubChem = 4066
| DrugBank = APRD00386
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| C=20 | H=22 | N=2 | S=1
| DrugBank = DB01071
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 3926
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = Y463242LY2
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01324
 
<!--Chemical data-->
| C=20 | H=22 | N=2 | S=1  
| molecular_weight = 322.468 g/mol
| molecular_weight = 322.468 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
| routes_of_administration =
}}
}}
__NOTOC__
{{SI}}
{{SI}}
{{EH}}
{{CMG}}
==Overview==
'''Mequitazine''' (trade name '''Primalan''') is an [[antihistamine]] and [[anticholinergic]] of the [[phenothiazine]] [[chemical class]]. It is used to treat [[allergies]] and [[rhinitis]].


'''Mequitazine''' is an [[antihistamine]].
==Contraindications==
Severe liver disease; premature infants or full-term neonates .


==External links==
==Special precautions==
* {{cite journal | author = Ramírez Chanona N, del Rio Navarro B, Pérez Martín J | title = Efficacy of mequitazine (Primalan) on the relief of symptoms of [[allergic]] rhinoconjunctivitis in children. Documented clinical experience | journal = Rev Alerg Mex | volume = 52 | issue = 6 | pages = 221-5 | year = | id = PMID 16568706}}
Pregnancy, lactation; severe CardioVascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.
* {{cite journal | author = Theunissen E, Vermeeren A, van Oers A, van Maris I, Ramaekers J | title = A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and [[placebo]]. | journal = Clin Exp Allergy | volume = 34 | issue = 2 | pages = 250-8 | year = 2004 | id = PMID 14987305}}
 
* {{cite journal | author = Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T | title = Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human [[liver]] microsomes. | journal = J Pharmacol Exp Ther | volume = 284 | issue = 2 | pages = 437-42 | year = 1998 | id = PMID 9454781}}
==Adverse drug reactions==
* {{cite journal | author = Persi L, Dupin O, Arnaud B, Trinquand C, Michel F, Bousquet J | title = Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic [[conjunctivitis]]. | journal = Allergy | volume = 52 | issue = 4 | pages = 451-4 | year = 1997 | id = PMID 9188930}}
CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.
 
==Drug Interactions==
Enhanced effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation reported with spiramycin.
 
== See also ==
* [[Phenothiazine]]
 
==References==
{{reflist|2}}


{{Antihistamines}}
{{Antihistamines}}


{{SIB}}
[[Category:Phenothiazines]]
[[Category: Antihistamines]]
[[Category:Drug]]
 
[[th:มีควิทาซีน]]
{{WH}}
{{WikiDoc Sources}}

Latest revision as of 17:23, 8 April 2015

Mequitazine
Clinical data
Trade namesPrimalan
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC20H22N2S
Molar mass322.468 g/mol
 ☒N☑Y (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mequitazine (trade name Primalan) is an antihistamine and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

Contraindications

Severe liver disease; premature infants or full-term neonates .

Special precautions

Pregnancy, lactation; severe CardioVascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.

Adverse drug reactions

CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.

Drug Interactions

Enhanced effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation reported with spiramycin.

See also

References

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