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Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and a potent anticholinergic.

Common use

Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine.

It also used to discourage abuse in certain opiate analgesics due its unpleasant side effects at high doses.

Adverse effects

Common adverse effects are those associated with most anticholinergics, effects are more pronounced in children and the elderly.



Phenyltoloxamine is available in most countries, though is rare in several western countries it remains widely used around the world, particularly in the developing world.

It is not a controlled substance; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with acetaminophen is generally over the counter.

Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world:

  • Ed-Flex, Dologesic, Flextra-650, Novagesic, Phenylgesic - North America
  • Codipront - Europe/South America