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==Primary Prevention== | ==Primary Prevention== | ||
*Effective measures for the primary prevention of [disease name] include: | *Effective measures for the primary prevention of [disease name] include: | ||
**[Measure1] | **[Measure1] | ||
**[Measure2] | **[Measure2] | ||
**[Measure3] | **[Measure3] | ||
==Risk Factors== | |||
*[ | Common risk factors in the development of IBS may be categorized as [[Psychological Science (journal)|psychological]], [[Epidemiology|epidemiological]], [[Genetics|genetic]], and [[Infection|infectious]]. | ||
**[ | ===Common Risk Factors=== | ||
**[ | *Common risk factors in the development of IBS include: | ||
**[ | **Psychological risk factors such as [[Stress (medicine)|stress]], [[anxiety]]<ref name="pmid216977452">{{cite journal |vauthors=Devanarayana NM, Mettananda S, Liyanarachchi C, Nanayakkara N, Mendis N, Perera N, Rajindrajith S |title=Abdominal pain-predominant functional gastrointestinal diseases in children and adolescents: prevalence, symptomatology, and association with emotional stress |journal=J. Pediatr. Gastroenterol. Nutr. |volume=53 |issue=6 |pages=659–65 |year=2011 |pmid=21697745 |doi=10.1097/MPG.0b013e3182296033 |url=}}</ref><ref name="pmid253398012">{{cite journal |vauthors=Qin HY, Cheng CW, Tang XD, Bian ZX |title=Impact of psychological stress on irritable bowel syndrome |journal=World J. Gastroenterol. |volume=20 |issue=39 |pages=14126–31 |year=2014 |pmid=25339801 |pmc=4202343 |doi=10.3748/wjg.v20.i39.14126 |url=}}</ref><ref name="pmid274929162">{{cite journal |vauthors=Bharucha AE, Chakraborty S, Sletten CD |title=Common Functional Gastroenterological Disorders Associated With Abdominal Pain |journal=Mayo Clin. Proc. |volume=91 |issue=8 |pages=1118–32 |year=2016 |pmid=27492916 |pmc=4985027 |doi=10.1016/j.mayocp.2016.06.003 |url=}}</ref><ref name="pmid266749802">{{cite journal |vauthors=Ibrahim NK |title=A systematic review of the prevalence and risk factors of irritable bowel syndrome among medical students |journal=Turk J Gastroenterol |volume=27 |issue=1 |pages=10–6 |year=2016 |pmid=26674980 |doi=10.5152/tjg.2015.150333 |url=}}</ref> | ||
**Psychiatric risk factors such as [[depression]], [[Panic disorder|panic disorders]]<ref name="pmid253398012" /><ref name="pmid274929162" /><ref name="pmid170076342">{{cite journal |vauthors=Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA |title=Migraine, fibromyalgia, and depression among people with IBS: a prevalence study |journal=BMC Gastroenterol |volume=6 |issue= |pages=26 |year=2006 |pmid=17007634 |pmc=1592499 |doi=10.1186/1471-230X-6-26 |url=}}</ref><ref name="pmid248767252">{{cite journal |vauthors=Hausteiner-Wiehle C, Henningsen P |title=Irritable bowel syndrome: relations with functional, mental, and somatoform disorders |journal=World J. Gastroenterol. |volume=20 |issue=20 |pages=6024–30 |year=2014 |pmid=24876725 |pmc=4033442 |doi=10.3748/wjg.v20.i20.6024 |url=}}</ref> | |||
**History of physical or [[Sexual assault|sexual abuse]] or adverse early life events | |||
**History of gastrointestinal disorders such as [[Inflammatory bowel disease|IBD]]<ref name="pmid242964622">{{cite journal |vauthors=Major G, Spiller R |title=Irritable bowel syndrome, inflammatory bowel disease and the microbiome |journal=Curr Opin Endocrinol Diabetes Obes |volume=21 |issue=1 |pages=15–21 |year=2014 |pmid=24296462 |pmc=3871405 |doi=10.1097/MED.0000000000000032 |url=}}</ref><ref name="pmid280580092">{{cite journal |vauthors=Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY |title=Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases |journal=World J. Gastroenterol. |volume=22 |issue=47 |pages=10275–10286 |year=2016 |pmid=28058009 |pmc=5175241 |doi=10.3748/wjg.v22.i47.10275 |url=}}</ref> | |||
**History of acute GI infections such as [[Traveler's diarrhea]] i.e post [[Infection|infectious]] state <ref name="pmid243796222">{{cite journal |vauthors=Halliez MC, Buret AG |title=Extra-intestinal and long term consequences of Giardia duodenalis infections |journal=World J. Gastroenterol. |volume=19 |issue=47 |pages=8974–85 |year=2013 |pmid=24379622 |pmc=3870550 |doi=10.3748/wjg.v19.i47.8974 |url=}}</ref><ref name="pmid227304682">{{cite journal |vauthors=Simrén M, Barbara G, Flint HJ, Spiegel BM, Spiller RC, Vanner S, Verdu EF, Whorwell PJ, Zoetendal EG |title=Intestinal microbiota in functional bowel disorders: a Rome foundation report |journal=Gut |volume=62 |issue=1 |pages=159–76 |year=2013 |pmid=22730468 |pmc=3551212 |doi=10.1136/gutjnl-2012-302167 |url=}}</ref><ref name="pmid228950812">{{cite journal |vauthors=Jeffery IB, Quigley EM, Öhman L, Simrén M, O'Toole PW |title=The microbiota link to irritable bowel syndrome: an emerging story |journal=Gut Microbes |volume=3 |issue=6 |pages=572–6 |year=2012 |pmid=22895081 |pmc=3495796 |doi=10.4161/gmic.21772 |url=}}</ref><ref name="pmid275982742">{{cite journal |vauthors=Ibarra C, Herrera V, Pérez de Arce E, Gil LC, Madrid AM, Valenzuela L, Beltrán CJ |title=[Parasitosis and irritable bowel syndrome] |language=Spanish; Castilian |journal=Rev Chilena Infectol |volume=33 |issue=3 |pages=268–74 |year=2016 |pmid=27598274 |doi=10.4067/S0716-10182016000300003 |url=}}</ref><ref name="pmid269001162">{{cite journal |vauthors=Giddings SL, Stevens AM, Leung DT |title=Traveler's Diarrhea |journal=Med. Clin. North Am. |volume=100 |issue=2 |pages=317–30 |year=2016 |pmid=26900116 |pmc=4764790 |doi=10.1016/j.mcna.2015.08.017 |url=}}</ref><ref name="pmid254161622">{{cite journal |vauthors=Keithlin J, Sargeant J, Thomas MK, Fazil A |title=Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae |journal=BMC Public Health |volume=14 |issue= |pages=1203 |year=2014 |pmid=25416162 |pmc=4391665 |doi=10.1186/1471-2458-14-1203 |url=}}</ref><ref name="pmid246040372">{{cite journal |vauthors=Grover M |title=Role of gut pathogens in development of irritable bowel syndrome |journal=Indian J. Med. Res. |volume=139 |issue=1 |pages=11–8 |year=2014 |pmid=24604037 |pmc=3994726 |doi= |url=}}</ref><ref name="pmid244047802">{{cite journal |vauthors=Keithlin J, Sargeant J, Thomas MK, Fazil A |title=Chronic sequelae of E. coli O157: systematic review and meta-analysis of the proportion of E. coli O157 cases that develop chronic sequelae |journal=Foodborne Pathog. Dis. |volume=11 |issue=2 |pages=79–95 |year=2014 |pmid=24404780 |pmc=3925333 |doi=10.1089/fpd.2013.1572 |url=}}</ref><ref name="pmid239925732">{{cite journal |vauthors=Connor BA, Riddle MS |title=Post-infectious sequelae of travelers' diarrhea |journal=J Travel Med |volume=20 |issue=5 |pages=303–12 |year=2013 |pmid=23992573 |doi=10.1111/jtm.12049 |url=}}</ref> | |||
***[[Salmonella]] infection | |||
***[[Giardiasis]] | |||
**History of [[antibiotic]] use<ref name="pmid282741082">{{cite journal |vauthors=Ghoshal UC, Shukla R, Ghoshal U |title=Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy |journal=Gut Liver |volume=11 |issue=2 |pages=196–208 |year=2017 |pmid=28274108 |pmc=5347643 |doi=10.5009/gnl16126 |url=}}</ref><ref name="pmid276215672">{{cite journal |vauthors=Gallo A, Passaro G, Gasbarrini A, Landolfi R, Montalto M |title=Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate |journal=World J. Gastroenterol. |volume=22 |issue=32 |pages=7186–202 |year=2016 |pmid=27621567 |pmc=4997632 |doi=10.3748/wjg.v22.i32.7186 |url=}}</ref><ref name="pmid269002862">{{cite journal |vauthors=Distrutti E, Monaldi L, Ricci P, Fiorucci S |title=Gut microbiota role in irritable bowel syndrome: New therapeutic strategies |journal=World J. Gastroenterol. |volume=22 |issue=7 |pages=2219–41 |year=2016 |pmid=26900286 |pmc=4734998 |doi=10.3748/wjg.v22.i7.2219 |url=}}</ref><ref name="pmid253942362">{{cite journal |vauthors=Shreiner AB, Kao JY, Young VB |title=The gut microbiome in health and in disease |journal=Curr. Opin. Gastroenterol. |volume=31 |issue=1 |pages=69–75 |year=2015 |pmid=25394236 |pmc=4290017 |doi=10.1097/MOG.0000000000000139 |url=}}</ref> | |||
**[[Immune-mediated disease|Immune]] causes:<ref name="pmid242964622" /> | |||
***History of [[Inflammatory bowel disease|IBD]] | |||
***[[Celiac disease]] | |||
***[[Microscopic colitis]] | |||
===Less Common Risk Factors=== | |||
*Less common risk factors in the development of IBS include: | |||
**Age: Second decade of life<ref name="pmid233248722">{{cite journal |vauthors=Goodwin L, White PD, Hotopf M, Stansfeld SA, Clark C |title=Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort |journal=Psychosom Med |volume=75 |issue=2 |pages=202–10 |year=2013 |pmid=23324872 |doi=10.1097/PSY.0b013e31827c351b |url=}}</ref> | |||
**Gender: Women(possibly due to changes in [[menstrual cycle]]) | |||
**Past history of abuse | |||
**Family history of [[Irritable bowel syndrome|IBS]] ([[Genetics]]) <ref name="pmid265257752">{{cite journal |vauthors=Makker J, Chilimuri S, Bella JN |title=Genetic epidemiology of irritable bowel syndrome |journal=World J. Gastroenterol. |volume=21 |issue=40 |pages=11353–61 |year=2015 |pmid=26525775 |pmc=4616211 |doi=10.3748/wjg.v21.i40.11353 |url=}}</ref> | |||
**[[Hormone|Hormonal]] changes<ref name="pmid246275812">{{cite journal |vauthors=Mulak A, Taché Y, Larauche M |title=Sex hormones in the modulation of irritable bowel syndrome |journal=World J. Gastroenterol. |volume=20 |issue=10 |pages=2433–48 |year=2014 |pmid=24627581 |pmc=3949254 |doi=10.3748/wjg.v20.i10.2433 |url=}}</ref><ref name="pmid16611266">{{cite journal |vauthors=Mawe GM, Coates MD, Moses PL |title=Review article: intestinal serotonin signalling in irritable bowel syndrome |journal=Aliment. Pharmacol. Ther. |volume=23 |issue=8 |pages=1067–76 |year=2006 |pmid=16611266 |doi=10.1111/j.1365-2036.2006.02858.x |url=}}</ref> | |||
***Alteration of [[Sex steroid|sex hormones]] | |||
***Alteration of [[serotonin]] levels | |||
**History of [[Migraine Headache|migraine]] headaches<ref name="pmid170076342" /><ref name="pmid164195712">{{cite journal |vauthors=Mulak A, Paradowski L |title=[Migraine and irritable bowel syndrome] |language=Polish |journal=Neurol. Neurochir. Pol. |volume=39 |issue=4 Suppl 1 |pages=S55–60 |year=2005 |pmid=16419571 |doi= |url=}}</ref><ref name="pmid276886562">{{cite journal |vauthors=Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A |title=Gastrointestinal disorders associated with migraine: A comprehensive review |journal=World J. Gastroenterol. |volume=22 |issue=36 |pages=8149–60 |year=2016 |pmid=27688656 |pmc=5037083 |doi=10.3748/wjg.v22.i36.8149 |url=}}</ref><ref name="pmid224471322">{{cite journal |vauthors=Cady RK, Farmer K, Dexter JK, Hall J |title=The bowel and migraine: update on celiac disease and irritable bowel syndrome |journal=Curr Pain Headache Rep |volume=16 |issue=3 |pages=278–86 |year=2012 |pmid=22447132 |doi=10.1007/s11916-012-0258-y |url=}}</ref> | |||
**History of pain disorders such as [[fibromyalgia]]<ref name="pmid170076342" /><ref name="pmid248799162">{{cite journal |vauthors=Vehof J, Zavos HM, Lachance G, Hammond CJ, Williams FM |title=Shared genetic factors underlie chronic pain syndromes |journal=Pain |volume=155 |issue=8 |pages=1562–8 |year=2014 |pmid=24879916 |doi=10.1016/j.pain.2014.05.002 |url=}}</ref> | |||
**Food sensitivities: Fatty food, wheat, carbonated drinks, sorbitol and alcohol<ref name="pmid232561172">{{cite journal |vauthors=Chirila I, Petrariu FD, Ciortescu I, Mihai C, Drug VL |title=Diet and irritable bowel syndrome |journal=J Gastrointestin Liver Dis |volume=21 |issue=4 |pages=357–62 |year=2012 |pmid=23256117 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 05:38, 27 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no established measures for the primary prevention of [disease name].
OR
There are no available vaccines against [disease name].
OR
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
OR
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].
Primary Prevention
Stress—feeling mentally or emotionally tense, troubled, angry, or overwhelmed—can stimulate colon spasms in people with IBS. The colon has many nerves that connect it to the brain. Like the heart and the lungs, the colon is partly controlled by the autonomic nervous system, which responds to stress. These nerves control the normal contractions of the colon and cause abdominal discomfort at stressful times. People often experience cramps or “butterflies” when they are nervous or upset. In people with IBS, the colon can be overly responsive to even slight conflict or stress. Stress makes the mind more aware of the sensations that arise in the colon, making the person perceive these sensations as unpleasant.
Some evidence suggests that IBS is affected by the immune system, which fights infection in the body. The immune system is affected by stress. For all these reasons, stress management is an important part of treatment for IBS. Stress management options include
- Stress reduction (relaxation) training and relaxation therapies such as meditation
- Counseling and support
- Regular exercise such as walking or yoga
- Changes to the stressful situations in your life
- Adequate sleep
Primary Prevention
- Effective measures for the primary prevention of [disease name] include:
- [Measure1]
- [Measure2]
- [Measure3]
Risk Factors
Common risk factors in the development of IBS may be categorized as psychological, epidemiological, genetic, and infectious.
Common Risk Factors
- Common risk factors in the development of IBS include:
- Psychological risk factors such as stress, anxiety[1][2][3][4]
- Psychiatric risk factors such as depression, panic disorders[2][3][5][6]
- History of physical or sexual abuse or adverse early life events
- History of gastrointestinal disorders such as IBD[7][8]
- History of acute GI infections such as Traveler's diarrhea i.e post infectious state [9][10][11][12][13][14][15][16][17]
- Salmonella infection
- Giardiasis
- History of antibiotic use[18][19][20][21]
- Immune causes:[7]
- History of IBD
- Celiac disease
- Microscopic colitis
Less Common Risk Factors
- Less common risk factors in the development of IBS include:
- Age: Second decade of life[22]
- Gender: Women(possibly due to changes in menstrual cycle)
- Past history of abuse
- Family history of IBS (Genetics) [23]
- Hormonal changes[24][25]
- Alteration of sex hormones
- Alteration of serotonin levels
- History of migraine headaches[5][26][27][28]
- History of pain disorders such as fibromyalgia[5][29]
- Food sensitivities: Fatty food, wheat, carbonated drinks, sorbitol and alcohol[30]
References
- ↑ Devanarayana NM, Mettananda S, Liyanarachchi C, Nanayakkara N, Mendis N, Perera N, Rajindrajith S (2011). "Abdominal pain-predominant functional gastrointestinal diseases in children and adolescents: prevalence, symptomatology, and association with emotional stress". J. Pediatr. Gastroenterol. Nutr. 53 (6): 659–65. doi:10.1097/MPG.0b013e3182296033. PMID 21697745.
- ↑ 2.0 2.1 Qin HY, Cheng CW, Tang XD, Bian ZX (2014). "Impact of psychological stress on irritable bowel syndrome". World J. Gastroenterol. 20 (39): 14126–31. doi:10.3748/wjg.v20.i39.14126. PMC 4202343. PMID 25339801.
- ↑ 3.0 3.1 Bharucha AE, Chakraborty S, Sletten CD (2016). "Common Functional Gastroenterological Disorders Associated With Abdominal Pain". Mayo Clin. Proc. 91 (8): 1118–32. doi:10.1016/j.mayocp.2016.06.003. PMC 4985027. PMID 27492916.
- ↑ Ibrahim NK (2016). "A systematic review of the prevalence and risk factors of irritable bowel syndrome among medical students". Turk J Gastroenterol. 27 (1): 10–6. doi:10.5152/tjg.2015.150333. PMID 26674980.
- ↑ 5.0 5.1 5.2 Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA (2006). "Migraine, fibromyalgia, and depression among people with IBS: a prevalence study". BMC Gastroenterol. 6: 26. doi:10.1186/1471-230X-6-26. PMC 1592499. PMID 17007634.
- ↑ Hausteiner-Wiehle C, Henningsen P (2014). "Irritable bowel syndrome: relations with functional, mental, and somatoform disorders". World J. Gastroenterol. 20 (20): 6024–30. doi:10.3748/wjg.v20.i20.6024. PMC 4033442. PMID 24876725.
- ↑ 7.0 7.1 Major G, Spiller R (2014). "Irritable bowel syndrome, inflammatory bowel disease and the microbiome". Curr Opin Endocrinol Diabetes Obes. 21 (1): 15–21. doi:10.1097/MED.0000000000000032. PMC 3871405. PMID 24296462.
- ↑ Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY (2016). "Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases". World J. Gastroenterol. 22 (47): 10275–10286. doi:10.3748/wjg.v22.i47.10275. PMC 5175241. PMID 28058009.
- ↑ Halliez MC, Buret AG (2013). "Extra-intestinal and long term consequences of Giardia duodenalis infections". World J. Gastroenterol. 19 (47): 8974–85. doi:10.3748/wjg.v19.i47.8974. PMC 3870550. PMID 24379622.
- ↑ Simrén M, Barbara G, Flint HJ, Spiegel BM, Spiller RC, Vanner S, Verdu EF, Whorwell PJ, Zoetendal EG (2013). "Intestinal microbiota in functional bowel disorders: a Rome foundation report". Gut. 62 (1): 159–76. doi:10.1136/gutjnl-2012-302167. PMC 3551212. PMID 22730468.
- ↑ Jeffery IB, Quigley EM, Öhman L, Simrén M, O'Toole PW (2012). "The microbiota link to irritable bowel syndrome: an emerging story". Gut Microbes. 3 (6): 572–6. doi:10.4161/gmic.21772. PMC 3495796. PMID 22895081.
- ↑ Ibarra C, Herrera V, Pérez de Arce E, Gil LC, Madrid AM, Valenzuela L, Beltrán CJ (2016). "[Parasitosis and irritable bowel syndrome]". Rev Chilena Infectol (in Spanish; Castilian). 33 (3): 268–74. doi:10.4067/S0716-10182016000300003. PMID 27598274.
- ↑ Giddings SL, Stevens AM, Leung DT (2016). "Traveler's Diarrhea". Med. Clin. North Am. 100 (2): 317–30. doi:10.1016/j.mcna.2015.08.017. PMC 4764790. PMID 26900116.
- ↑ Keithlin J, Sargeant J, Thomas MK, Fazil A (2014). "Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae". BMC Public Health. 14: 1203. doi:10.1186/1471-2458-14-1203. PMC 4391665. PMID 25416162.
- ↑ Grover M (2014). "Role of gut pathogens in development of irritable bowel syndrome". Indian J. Med. Res. 139 (1): 11–8. PMC 3994726. PMID 24604037.
- ↑ Keithlin J, Sargeant J, Thomas MK, Fazil A (2014). "Chronic sequelae of E. coli O157: systematic review and meta-analysis of the proportion of E. coli O157 cases that develop chronic sequelae". Foodborne Pathog. Dis. 11 (2): 79–95. doi:10.1089/fpd.2013.1572. PMC 3925333. PMID 24404780.
- ↑ Connor BA, Riddle MS (2013). "Post-infectious sequelae of travelers' diarrhea". J Travel Med. 20 (5): 303–12. doi:10.1111/jtm.12049. PMID 23992573.
- ↑ Ghoshal UC, Shukla R, Ghoshal U (2017). "Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy". Gut Liver. 11 (2): 196–208. doi:10.5009/gnl16126. PMC 5347643. PMID 28274108.
- ↑ Gallo A, Passaro G, Gasbarrini A, Landolfi R, Montalto M (2016). "Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate". World J. Gastroenterol. 22 (32): 7186–202. doi:10.3748/wjg.v22.i32.7186. PMC 4997632. PMID 27621567.
- ↑ Distrutti E, Monaldi L, Ricci P, Fiorucci S (2016). "Gut microbiota role in irritable bowel syndrome: New therapeutic strategies". World J. Gastroenterol. 22 (7): 2219–41. doi:10.3748/wjg.v22.i7.2219. PMC 4734998. PMID 26900286.
- ↑ Shreiner AB, Kao JY, Young VB (2015). "The gut microbiome in health and in disease". Curr. Opin. Gastroenterol. 31 (1): 69–75. doi:10.1097/MOG.0000000000000139. PMC 4290017. PMID 25394236.
- ↑ Goodwin L, White PD, Hotopf M, Stansfeld SA, Clark C (2013). "Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort". Psychosom Med. 75 (2): 202–10. doi:10.1097/PSY.0b013e31827c351b. PMID 23324872.
- ↑ Makker J, Chilimuri S, Bella JN (2015). "Genetic epidemiology of irritable bowel syndrome". World J. Gastroenterol. 21 (40): 11353–61. doi:10.3748/wjg.v21.i40.11353. PMC 4616211. PMID 26525775.
- ↑ Mulak A, Taché Y, Larauche M (2014). "Sex hormones in the modulation of irritable bowel syndrome". World J. Gastroenterol. 20 (10): 2433–48. doi:10.3748/wjg.v20.i10.2433. PMC 3949254. PMID 24627581.
- ↑ Mawe GM, Coates MD, Moses PL (2006). "Review article: intestinal serotonin signalling in irritable bowel syndrome". Aliment. Pharmacol. Ther. 23 (8): 1067–76. doi:10.1111/j.1365-2036.2006.02858.x. PMID 16611266.
- ↑ Mulak A, Paradowski L (2005). "[Migraine and irritable bowel syndrome]". Neurol. Neurochir. Pol. (in Polish). 39 (4 Suppl 1): S55–60. PMID 16419571.
- ↑ Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A (2016). "Gastrointestinal disorders associated with migraine: A comprehensive review". World J. Gastroenterol. 22 (36): 8149–60. doi:10.3748/wjg.v22.i36.8149. PMC 5037083. PMID 27688656.
- ↑ Cady RK, Farmer K, Dexter JK, Hall J (2012). "The bowel and migraine: update on celiac disease and irritable bowel syndrome". Curr Pain Headache Rep. 16 (3): 278–86. doi:10.1007/s11916-012-0258-y. PMID 22447132.
- ↑ Vehof J, Zavos HM, Lachance G, Hammond CJ, Williams FM (2014). "Shared genetic factors underlie chronic pain syndromes". Pain. 155 (8): 1562–8. doi:10.1016/j.pain.2014.05.002. PMID 24879916.
- ↑ Chirila I, Petrariu FD, Ciortescu I, Mihai C, Drug VL (2012). "Diet and irritable bowel syndrome". J Gastrointestin Liver Dis. 21 (4): 357–62. PMID 23256117.