Irritable bowel syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sudarshana Datta, MD [2]


There is no definite cause for irritable bowel syndrome (IBS). However, an interplay of several factors contribute to the development of IBS such as emotional disturbances, stress, adverse early life events, history of inflammatory bowel disease, and acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes.


Irritable bowel syndrome (IBS) results from a complex interaction among multiple factors. These may include psychological, epidemiological, genetic, and infectious factors. To review these factors in detail, click here.

Genetic causes

Genetic causes IBS is associated with high twin concordance, familial aggregation, Single nucleotide polymorphisms and TNF polymorphisms in genes.[1][2]


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