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==Overview==
==Overview==
Discovery of the hypopituitarism returns back to 1914 when Dr. Simmonds described the [[disease]] for the first time. The diagnosis has been based on the patients' presentation only since then till 1950 when Dr. Yalow and Berson discovered the [[radioimmunoassay]] which helped in the measurement the [[hormonal]] levels. Through the 20th and 21st centuries, causes of the hypopituitarism were being described.
Hypopituitarism was first described by Dr. Simmonds for the first time in 1914. Dr. Yalow and Berson discovered the [[radioimmunoassay]], in 1950. Causes of the hypopituitarism were being described through the 20th and 21st centuries.


==Historical Perspective==
==Historical Perspective==
*In 1914, Dr. Simmonds was the first one to describe the hypopituitarism. He described it as the inability of the [[pituitary gland]] to secrete [[hormones]] matching the [[organs]] need.<ref name="pmid17467517">{{cite journal| author=Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E| title=Hypopituitarism. | journal=Lancet | year= 2007 | volume= 369 | issue= 9571 | pages= 1461-70 | pmid=17467517 | doi=10.1016/S0140-6736(07)60673-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17467517  }} </ref>
*In 1914, Dr. Simmonds was the first one to describe hypopituitarism. He described it as the inability of the [[pituitary gland]] to secrete [[hormones]] matching the [[organs]] need.<ref name="pmid17467517">{{cite journal| author=Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E| title=Hypopituitarism. | journal=Lancet | year= 2007 | volume= 369 | issue= 9571 | pages= 1461-70 | pmid=17467517 | doi=10.1016/S0140-6736(07)60673-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17467517  }} </ref>
*In 1950, Dr. Yalow and Berson discovered the [[radioimmunoassay]] which helped in the measurement of the [[Pituitary gland|pituitary]] [[hormones]] after the diagnosis was only based on the signs and symptoms presented by the patients.<ref name="pmid441860">{{cite journal| author=Prozesky OW| title=Measles vaccination. | journal=S Afr Med J | year= 1979 | volume= 55 | issue= 7 | pages= 236 | pmid=441860 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=441860  }} </ref>
*In 1950, Dr. Yalow and Berson discovered the [[radioimmunoassay]], which helped with the measurement of the [[Pituitary gland|pituitary]] [[hormones]] for the diagnosis of hypopituitarism. Previously, it was based on only the presenting [[Signs and Symptoms|signs and symptoms]] of the patients.<ref name="pmid441860">{{cite journal| author=Prozesky OW| title=Measles vaccination. | journal=S Afr Med J | year= 1979 | volume= 55 | issue= 7 | pages= 236 | pmid=441860 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=441860  }} </ref>
*In 1973, combined stimulation tests of the hormones [[insulin]], [[GnRH]], and [[TRH]] were performed for the first time to assess the [[pituitary gland]] function.<ref name="pmid4202260">{{cite journal| author=Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR| title=Combined test for assessment of anterior pituitary function. | journal=Br Med J | year= 1973 | volume= 4 | issue= 5888 | pages= 326-9 | pmid=4202260 | doi= | pmc=1587416 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4202260  }} </ref>
*In 1973, combined stimulation tests of [[insulin]], [[Gonadotropin-releasing hormone|gonadotrophin releasing hormone]] ([[GnRH]]), and [[Thyrotropin-releasing hormone|thyroid releasing hormone]] ([[TRH]]) were performed for the first time, to assess the [[pituitary gland]] function.<ref name="pmid4202260">{{cite journal| author=Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR| title=Combined test for assessment of anterior pituitary function. | journal=Br Med J | year= 1973 | volume= 4 | issue= 5888 | pages= 326-9 | pmid=4202260 | doi= | pmc=1587416 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4202260  }} </ref>
*Through the 20th and 21st centuries, causes of the hypopituitarism were being described.
*Through the 20th and 21st centuries, causes of the hypopituitarism were further explained.


==References==
==References==
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{{Reflist|2}}
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[[Category:Medicine]]
[[Category:Endocrinology]]
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Latest revision as of 22:19, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Hypopituitarism was first described by Dr. Simmonds for the first time in 1914. Dr. Yalow and Berson discovered the radioimmunoassay, in 1950. Causes of the hypopituitarism were being described through the 20th and 21st centuries.

Historical Perspective

References

  1. Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E (2007). "Hypopituitarism". Lancet. 369 (9571): 1461–70. doi:10.1016/S0140-6736(07)60673-4. PMID 17467517.
  2. Prozesky OW (1979). "Measles vaccination". S Afr Med J. 55 (7): 236. PMID 441860.
  3. Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR (1973). "Combined test for assessment of anterior pituitary function". Br Med J. 4 (5888): 326–9. PMC 1587416. PMID 4202260.

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