Hairy cell leukemia MRI: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Hairy cell leukemia}} | {{Hairy cell leukemia}} | ||
{{CMG}} {{AE}}{{HL}} | {{CMG}}; {{AE}} {{HL}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
MRI of the femur may be helpful in the diagnosis of hairy cell leukemia. Diffuse hyperintense lesions on T2-weighted MRI image is suggestive of bone marrow infiltration by malignant leukemic cells. | [[MRI]] of the [[femur]] may be helpful in the diagnosis of [[hairy cell leukemia]]. [[Diffuse]] hyperintense lesions on T2-weighted [[Magnetic resonance imaging|MRI]] image is suggestive of [[bone marrow]] infiltration by [[malignant]] [[leukemic]] cells. | ||
==MRI== | ==MRI== | ||
[[Magnetic resonance imaging|MRI]] of the [[femur]] may be helpful in the diagnosis of [[hairy cell leukemia]]. Findings on [[MRI]] suggestive of [[hairy cell leukemia]] include:<ref name="pub1">{{cite journal |vauthors=Silingardi V, Davolio-Marani S, Federico M, Piccinini L, Frassoldati A, Sarti M, Burani A, Canossi G |title=Bone marrow infiltration in hairy cell leukemia after interferon therapy detected by magnetic resonance imaging |journal=Eur J Cancer Clin Oncol |volume=25 |issue=2 |pages=209–13 |year=1989 |pmid=2702977 |doi= |url=}}</ref><ref name="pub2">{{cite journal |vauthors=Thompson JA, Shields AF, Porter BA, Olson DO, Rubin E, Kidd P, Fefer A |title=Magnetic resonance imaging of bone marrow in hairy cell leukemia: correlation with clinical response to alpha-interferon |journal=Leukemia |volume=1 |issue=4 |pages=315–6 |year=1987 |pmid=3669752 |doi= |url=}}</ref><ref name="pub3">{{cite journal |vauthors=Gray MT, Rutherford MN, Bonin DM, Patterson B, Lopez PG |title=Hairy-cell leukemia presenting as lytic bone lesions |journal=J. Clin. Oncol. |volume=31 |issue=25 |pages=e410–2 |year=2013 |pmid=23797001 |doi=10.1200/JCO.2012.47.5301 |url=}}</ref><ref name="pmid12533048">{{cite journal |vauthors=Lal A, Tallman MS, Soble MB, Golubovich I, Peterson L |title=Hairy cell leukemia presenting as localized skeletal involvement |journal=Leuk. Lymphoma |volume=43 |issue=11 |pages=2207–11 |date=November 2002 |pmid=12533048 |doi=10.1080/1042819021000016122 |url=}}</ref> | |||
* [[Diffuse]] hyperintense lesions on T2-weighted [[Magnetic resonance imaging|MRI]] image | |||
* [[Bone marrow]] [[Infiltration (medical)|infiltration]] by [[malignant]] [[leukemic]] cells | |||
* Marrow-based lesion in the left [[femur]] neck, left proximal [[femur]] and both greater [[trochanters]] | |||
* [[Posterior]] [[iliac]] crest [[bone marrow]] involvement can be seen | |||
* Multiple hypointense [[Metastasis|metastatic]] bone [[Lesion|lesions]] on T1-weighted image | |||
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* | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 17:23, 8 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
MRI of the femur may be helpful in the diagnosis of hairy cell leukemia. Diffuse hyperintense lesions on T2-weighted MRI image is suggestive of bone marrow infiltration by malignant leukemic cells.
MRI
MRI of the femur may be helpful in the diagnosis of hairy cell leukemia. Findings on MRI suggestive of hairy cell leukemia include:[1][2][3][4]
- Diffuse hyperintense lesions on T2-weighted MRI image
- Bone marrow infiltration by malignant leukemic cells
- Marrow-based lesion in the left femur neck, left proximal femur and both greater trochanters
- Posterior iliac crest bone marrow involvement can be seen
- Multiple hypointense metastatic bone lesions on T1-weighted image
References
- ↑ Silingardi V, Davolio-Marani S, Federico M, Piccinini L, Frassoldati A, Sarti M, Burani A, Canossi G (1989). "Bone marrow infiltration in hairy cell leukemia after interferon therapy detected by magnetic resonance imaging". Eur J Cancer Clin Oncol. 25 (2): 209–13. PMID 2702977.
- ↑ Thompson JA, Shields AF, Porter BA, Olson DO, Rubin E, Kidd P, Fefer A (1987). "Magnetic resonance imaging of bone marrow in hairy cell leukemia: correlation with clinical response to alpha-interferon". Leukemia. 1 (4): 315–6. PMID 3669752.
- ↑ Gray MT, Rutherford MN, Bonin DM, Patterson B, Lopez PG (2013). "Hairy-cell leukemia presenting as lytic bone lesions". J. Clin. Oncol. 31 (25): e410–2. doi:10.1200/JCO.2012.47.5301. PMID 23797001.
- ↑ Lal A, Tallman MS, Soble MB, Golubovich I, Peterson L (November 2002). "Hairy cell leukemia presenting as localized skeletal involvement". Leuk. Lymphoma. 43 (11): 2207–11. doi:10.1080/1042819021000016122. PMID 12533048.