Hairy cell leukemia natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2], Vamsikrishna Gunnam M.B.B.S [3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]

Overview

Most patients with hairy cell leukemia are asymptomatic at the time of diagnosis. If left untreated, most of the patients with hairy cell leukemia will gradually develop anemia, recurrent infections, and bleeding. The complications of hairy cell leukemia are mainly due to bone marrow failure.

Natural History, Complications, and Prognosis

Natural History

Most patients with hairy cell leukemia are asymptomatic at the time of diagnosis.^[1]
If left untreated, most of the patients with hairy cell leukemia will gradually develop the following:
- Anemia
- Recurrent infections
- Bleeding

Complications

Common complications of hairy cell leukemia include:^[2]
- Anemia
- Recurrent infections
- Major recurrent bleeding
- Splenic rupture

Prognosis

Prognosis is generally good, and the 5-year survival rate of patients with chronic lymphocytic leukemia is approximately 90%.^[3]
Poor prognostic factors for hairy cell leukemia patients include old age, female gender, and African American race.^[4]
The table below lists prognostic factors for hairy cell leukemia patients:^[5]


Prognostic Factor	Description

Age	Older age at the time of diagnosis is associated with a worse prognosis.
Gender	Female are associated with a worse prognosis when compared to males.
Race	African American individuals are associated with a worse prognosis.
Infections	A recent history of pneumonia or the presence of major infection at the time of diagnosis are associated with a worse prognosis.
Hepatomegaly	The presence of hepatomegaly is associated with a worse prognosis.
Hemoglobin concentration	A hemoglobin concentration of ≤10 g/dl is associated with a poor prognosis.
Reticulocyte count	A reticulocyte count of <1% is associated with a worse prognosis.
Neutrophil count	A neutrophil count ≤350/μl is associated with a worse prognosis.

References

↑ Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.
↑ Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.
↑ Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.
↑ Rekha Chandran, Stuart K. Gardiner, Stephen D. Smith & Stephen E. Spurgeon (2013). "Improved survival in hairy cell leukaemia over three decades: a SEER database analysis of prognostic factors". British journal of haematology. 163 (3): 407–409. doi:10.1111/bjh.12490. PMID 23889044. Unknown parameter |month= ignored (help)
↑ Stewart DJ, Smith TL, Keating MJ, McCredie KB, Hersh EM, Quesada J, Freireich EJ (1984). "Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 53 (5): 1198–1201. PMID 6692307.

Template:WikiDoc Sources

[MatutesWotherspoon2001-1] Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.

[MatutesWotherspoon20012-2] Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.

[MatutesWotherspoon20013-3] Matutes, E; Wotherspoon, A; Brito-Babapulle, V; Catovsky, D (2001). "The natural history and clinico-pathological features of the variant form of hairy cell leukemia". Leukemia. 15 (1): 184–186. doi:10.1038/sj.leu.2401999. ISSN 0887-6924.

[4] Rekha Chandran, Stuart K. Gardiner, Stephen D. Smith & Stephen E. Spurgeon (2013). "Improved survival in hairy cell leukaemia over three decades: a SEER database analysis of prognostic factors". British journal of haematology. 163 (3): 407–409. doi:10.1111/bjh.12490. PMID 23889044. Unknown parameter |month= ignored (help)

[5] Stewart DJ, Smith TL, Keating MJ, McCredie KB, Hersh EM, Quesada J, Freireich EJ (1984). "Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 53 (5): 1198–1201. PMID 6692307.

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