Hairy cell leukemia MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

MRI of the femur may be helpful in the diagnosis of hairy cell leukemia. Diffuse hyperintense lesions on T2-weighted MRI image is suggestive of bone marrow infiltration by malignant leukemic cells.

MRI of the femur may be helpful in the diagnosis of hairy cell leukemia. Findings on MRI suggestive of hairy cell leukemia include:^[1]^[2]^[3]^[4]

Diffuse hyperintense lesions on T2-weighted MRI image
Bone marrow infiltration by malignant leukemic cells
Marrow-based lesion in the left femur neck, left proximal femur and both greater trochanters
Posterior iliac crest bone marrow involvement can be seen
Multiple hypointense metastatic bone lesions on T1-weighted image

↑ Silingardi V, Davolio-Marani S, Federico M, Piccinini L, Frassoldati A, Sarti M, Burani A, Canossi G (1989). "Bone marrow infiltration in hairy cell leukemia after interferon therapy detected by magnetic resonance imaging". Eur J Cancer Clin Oncol. 25 (2): 209–13. PMID 2702977.
↑ Thompson JA, Shields AF, Porter BA, Olson DO, Rubin E, Kidd P, Fefer A (1987). "Magnetic resonance imaging of bone marrow in hairy cell leukemia: correlation with clinical response to alpha-interferon". Leukemia. 1 (4): 315–6. PMID 3669752.
↑ Gray MT, Rutherford MN, Bonin DM, Patterson B, Lopez PG (2013). "Hairy-cell leukemia presenting as lytic bone lesions". J. Clin. Oncol. 31 (25): e410–2. doi:10.1200/JCO.2012.47.5301. PMID 23797001.
↑ Lal A, Tallman MS, Soble MB, Golubovich I, Peterson L (November 2002). "Hairy cell leukemia presenting as localized skeletal involvement". Leuk. Lymphoma. 43 (11): 2207–11. doi:10.1080/1042819021000016122. PMID 12533048.