Hairy cell leukemia differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2], James Nasr[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, splenic B-cell neoplasms, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differentiating Hairy cell leukemia from other Diseases
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, splenic B-cell neoplasms, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1][2][3][4][5]
| Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 | |
|---|---|---|---|---|---|---|---|
|
Hairy cell leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive | |
|
Chronic lymphocytic leukaemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative | |
|
Prolymphocytic leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative | |
|
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative | |
|
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative | |
|
Hairy Cell Leukemia Variant |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Positive |
- Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:[6][7]
References
- ↑ Troussard X, Cornet E (December 2017). "Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment". Am. J. Hematol. 92 (12): 1382–1390. doi:10.1002/ajh.24936. PMC 5698705. PMID 29110361.
- ↑ Sainati L, Matutes E, Mulligan S, de Oliveira MP, Rani S, Lampert IA, Catovsky D (July 1990). "A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients". Blood. 76 (1): 157–62. PMID 2364167.
- ↑ Abbrederis K, Michlmayr G, Schmalzl F (1979). "[Prolymphocytic and hairy cell leukemias as special forms of chronic lymphatic leukemia]". Acta Med. Austriaca (in German). 6 (5): 226–8. PMID 299012.
- ↑ Gazitt Y, Polliack A (1987). "Phorbol ester induction of plasmacytoid and hairy cell leukemia features in B-type lymphocytic leukemias: the relation to B-cell differentiation and maturation". Blood Cells. 12 (2): 413–39. PMID 3497682.
- ↑ Hasselbalch H, Lisse I, Berild D, Videbaek A (February 1984). "Spongy lymphoid myelofibrosis as a predictor of hairy cell leukaemia or a variant of hairy cell leukaemia without hairy cells?". Scand J Haematol. 32 (2): 135–44. PMID 6701458.
- ↑ Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM (January 1999). "Expression profiling using cDNA microarrays". Nat. Genet. 21 (1 Suppl): 10–4. doi:10.1038/4434. PMID 9915494.
- ↑ Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I (July 2004). "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature". Blood. 104 (1): 250–5. doi:10.1182/blood-2004-01-0181. PMID 15016649.