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__NOTOC__
{{Eosinophilic pneumonia}}
{{Eosinophilic pneumonia}}
{{CMG}} {{AE}} {{MAD}}


'''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:mgibson@perfuse.org] Phone:617-632-7753; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh@perfuse.org]
==Overview==
==Overview==
== Types of eosinophilic pneumonia ==
Causes of eosinophilic lung diseases are acute eosinophilic pneumonia, chrnoic eosinophilic pneumonia, [[tropical pulmonary eosinophilia]], [[Granulomatosis with polyangiitis|eosinophilic granulomatosis with polyangitis]], [[allergic bronchopulmonary aspergillosis]], and [[medications]] such as [[Non-steroidal anti-inflammatory drug|nonsteroidal anti-inflammatory drugs]], [[Anticonvulsants]], [[Antidepressants]], [[Angiotensin converting enzyme inhibitors]], and [[Beta blockers]].
Eosinophilic pneumonia is divided into different categories depending upon whether a cause can be determined or not. Known causes include certain [[medication]]s or environmental triggers, [[parasitic pneumonia|parasitic]] [[infection]]s, and [[cancer]]. EP can also occur when the [[immune system]] attacks the lungs, a disease called [[Churg-Strauss syndrome]]. When a cause can not be found, the EP is labeled "[[idiopathic]]." Idiopathic EP can be divided into "acute eosinophilic pneumonia" (AEP) and "chronic eosinophilic pneumonia" (CEP) depending on the symptoms a person is experiencing.{{ref|Bain}}
 
==References==
==Causes==
 
==== '''Acute eosinophilic pneumonia (AEP)''' ====
* The cause of acute eosinophilic pneumonia is unknown but an acute [[hypersensitivity reaction]] is suggested.<ref name="pmid27514599">{{cite journal| author=Cottin V| title=Eosinophilic Lung Diseases. | journal=Clin Chest Med | year= 2016 | volume= 37 | issue= 3 | pages= 535-56 | pmid=27514599 | doi=10.1016/j.ccm.2016.04.015 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27514599  }}</ref>
'''Chrnoic eosinophilic pneumonia (CEP)'''
* [[Chronic eosinophilic pneumonia]] is an  characterized by an abnormal and marked accumulation of [[eosinophils]] in the [[interstitium]] and alveolar spaces of [[Lung|the lung]].<ref name="pmid29404185">{{cite journal| author=Yıldız T, Dülger S| title=Non-astmatic Eosinophilic Bronchitis. | journal=Turk Thorac J | year= 2018 | volume= 19 | issue= 1 | pages= 41-45 | pmid=29404185 | doi=10.5152/TurkThoracJ.2017.17017 | pmc=5783052 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29404185  }}</ref>
 
==== '''Transpulmonary passage of [[Helminth|helminth larvae]] (Löffler syndrome)''' ====
* Three types of helminths, ''[[Ascariasis|Ascaris]]'', [[hookworms]], and ''[[Strongyloides stercoralis]]'', have larvae that reach the lungs, penetrate into [[alveoli]], and ascend the airways then reach the [[gastrointestinal tract]].
* ''[[Ascariasis|Ascaris]]'' is the most common cause of [[Löffler's syndrome|Löffler syndrome]] worldwide.<ref>{{Cite journal
 
| pmid = 13331628
}}</ref><ref name="pmid294693162">{{cite journal| author=Yang Z, Lei W, Xiao-Li L, Xiao-Jun T, Wei L, Yi-Jun A et al.| title=[Clinical features of imported schistosomiasis mansoni in Beijing City:a report of 6 cases]. | journal=Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi | year= 2017 | volume= 29 | issue= 2 | pages= 150-154 | pmid=29469316 | doi=10.16250/j.32.1374.2016207 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29469316  }}</ref>
 
==== '''Tropical pulmonary eosinophilia''' ====
* [[Tropical pulmonary eosinophilia]] is immune response to the [[Lymphatic filariasis|lymphatic filariae]] and [[Wuchereria bancrofti]].<ref>{{Cite journal
 
| pmid = 15486834
}}</ref>
* [[Pulmonary function tests]] may show a mixed restrictive and obstructive abnormality with a reduction in [[diffusion capacity]].<ref>{{Cite journal
 
| author = [[Jai B. Mullerpattan]], [[Zarir F. Udwadia]] & [[Farokh E. Udwadia]]
| title = Tropical pulmonary eosinophilia--a review
| journal = [[The Indian journal of medical research]]
| volume = 138
| issue = 3
| pages = 295–302
| year = 2013
| month = September
| pmid = 24135173
}}</ref>
 
==== '''Eosinophilic granulomatosis with polyangitis''' ====
* [[Eosinophilic granulomatosis with polyangiitis]] ([[Churg-Strauss syndrome|Churg-Strauss]]) is a vasculitic disorder often characterized by [[sinusitis]], [[asthma]], and prominent peripheral [[Eosinophilia|blood eosinophilia]].<ref>{{Cite journal
 
| author = [[L. Guillevin]], [[P. Cohen]], [[M. Gayraud]], [[F. Lhote]], [[B. Jarrousse]] & [[P. Casassus]]
| title = Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients
| journal = [[Medicine]]
| volume = 78
| issue = 1
| pages = 26–37
| year = 1999
| month = January
| pmid = 9990352
}}</ref>
* It is the sole form of [[vasculitis]] that is associated with both eosinophilia and frequent lung involvement.
* In addition to the lungs, the skin and the cardiovascular, gastrointestinal, renal, and neurologic systems may also be involved.
 
==== '''Allergic bronchopulmonary aspergillosis''' ====
* [[Allergic bronchopulmonary aspergillosis]] is a complex [[hypersensitivity reaction]] that occurs when airways become colonized by ''[[Aspergillus]].''<ref>{{Cite journal
 
| pmid = 16612769
}}</ref>
* Immunologic responses elicited by ''[[Aspergillus fumigatus]]'' are responsible for this syndrome. It can lead to [[bronchiectasis]], and [[fibrosis]].
 
==== Drugs and toxins ====
[[Drug reaction with eosinophilia and systemic symptoms]] (DRESS) is a [[Drug-induced hypersensitivity syndrome|drug-induced hypersensitivity reaction]] that includes skin eruption, [[eosinophilia]], [[Atypical lymphocyte|atypical lymphocytosis]], [[lymphadenopathy]], and kidney involvement. Drugs causing DRESS are:<ref>{{Cite journal
 
| author = [[Peter W. Kim]], [[Alfred F. Sorbello]], [[Ronald T. Wassel]], [[Tracy M. Pham]], [[Joseph M. Tonning]] & [[Sumathi Nambiar]]
| title = Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports
| journal = [[Drug safety]]
| volume = 35
| issue = 6
| pages = 447–457
| year = 2012
| month = June
| doi = 10.2165/11597460-000000000-00000
| pmid = 22612850
}}</ref>
* [[Non-steroidal anti-inflammatory drug|Nonsteroidal anti-inflammatory drugs]]
* [[Anticonvulsants]]
* [[Antidepressants]]
* [[Angiotensin converting enzyme inhibitors]]
* [[Beta blockers]]
* [[Hydrochlorothiazide]]
* [[Cocaine]]<ref name="pmid29487790">{{cite journal| author=Reyes F, Vaitkus V, Al-Ajam M| title=A case of cocaine-induced eosinophilic pneumonia: Case report and review of the literature. | journal=Respir Med Case Rep | year= 2018 | volume= 23 | issue=  | pages= 98-102 | pmid=29487790 | doi=10.1016/j.rmcr.2017.12.012 | pmc=5805849 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29487790  }}</ref>
 
== References ==
{{reflist|2}}
{{reflist|2}}
[[Category:Diseaase]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Infectious disease]]
[[Category:Disease]]
[[Category:Pneumonia|Pneumonia]]
[[Category:Emergency medicine]]
 
{{WH}}
{{WS}}

Latest revision as of 18:29, 29 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Overview

Causes of eosinophilic lung diseases are acute eosinophilic pneumonia, chrnoic eosinophilic pneumonia, tropical pulmonary eosinophilia, eosinophilic granulomatosis with polyangitis, allergic bronchopulmonary aspergillosis, and medications such as nonsteroidal anti-inflammatory drugs, Anticonvulsants, Antidepressants, Angiotensin converting enzyme inhibitors, and Beta blockers.

Causes

Acute eosinophilic pneumonia (AEP)

Chrnoic eosinophilic pneumonia (CEP)

Transpulmonary passage of helminth larvae (Löffler syndrome)

Tropical pulmonary eosinophilia

Eosinophilic granulomatosis with polyangitis

Allergic bronchopulmonary aspergillosis

Drugs and toxins

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that includes skin eruption, eosinophilia, atypical lymphocytosis, lymphadenopathy, and kidney involvement. Drugs causing DRESS are:[9]

References

  1. Cottin V (2016). "Eosinophilic Lung Diseases". Clin Chest Med. 37 (3): 535–56. doi:10.1016/j.ccm.2016.04.015. PMID 27514599.
  2. Yıldız T, Dülger S (2018). "Non-astmatic Eosinophilic Bronchitis". Turk Thorac J. 19 (1): 41–45. doi:10.5152/TurkThoracJ.2017.17017. PMC 5783052. PMID 29404185.
  3. . PMID 13331628. Missing or empty |title= (help)
  4. Yang Z, Lei W, Xiao-Li L, Xiao-Jun T, Wei L, Yi-Jun A; et al. (2017). "[Clinical features of imported schistosomiasis mansoni in Beijing City:a report of 6 cases]". Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 29 (2): 150–154. doi:10.16250/j.32.1374.2016207. PMID 29469316.
  5. . PMID 15486834. Missing or empty |title= (help)
  6. Jai B. Mullerpattan, Zarir F. Udwadia & Farokh E. Udwadia (2013). "Tropical pulmonary eosinophilia--a review". The Indian journal of medical research. 138 (3): 295–302. PMID 24135173. Unknown parameter |month= ignored (help)
  7. L. Guillevin, P. Cohen, M. Gayraud, F. Lhote, B. Jarrousse & P. Casassus (1999). "Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients". Medicine. 78 (1): 26–37. PMID 9990352. Unknown parameter |month= ignored (help)
  8. . PMID 16612769. Missing or empty |title= (help)
  9. Peter W. Kim, Alfred F. Sorbello, Ronald T. Wassel, Tracy M. Pham, Joseph M. Tonning & Sumathi Nambiar (2012). "Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports". Drug safety. 35 (6): 447–457. doi:10.2165/11597460-000000000-00000. PMID 22612850. Unknown parameter |month= ignored (help)
  10. Reyes F, Vaitkus V, Al-Ajam M (2018). "A case of cocaine-induced eosinophilic pneumonia: Case report and review of the literature". Respir Med Case Rep. 23: 98–102. doi:10.1016/j.rmcr.2017.12.012. PMC 5805849. PMID 29487790.