Delayed puberty history and symptoms: Difference between revisions

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==Overview==
==Overview==
The hallmark of delayed [[puberty]] is lack of [[testicular]] enlargement in boys or [[breast]] development in girls in a specific stage of life. The age, in which [[secondary sexual characteristics]] are checked, is 2-2.5 [[Standard deviation|SD]] more than the standard population average age of [[puberty]] onset. The age is 14 for boys and 13 for girls, on average. A positive [[family history]] of delayed [[puberty]] is strongly associated with delayed [[puberty]]. The most common contributing symptom of delayed [[puberty]] is [[anosmia]] or [[hyposmia]]. Less common symptoms of delayed [[puberty]] are including the symptoms related to its underlying [[diseases]].
The hallmark of delayed [[puberty]] is lack of [[testicular]] enlargement in boys or [[breast]] development in girls in a specific stage of life. The age, in which [[secondary sexual characteristics]] are checked, is 2-2.5 [[Standard deviation|SD]] more than the standard population average age of [[puberty]] onset; the age is 14 for boys and 13 for girls, on average. A positive [[family history]] of delayed [[puberty]] is strongly associated with delayed [[puberty]]. The most common contributing symptom of delayed [[puberty]] is [[anosmia]] or [[hyposmia]]. Less common symptoms of delayed [[puberty]] are including the symptoms related to its underlying [[diseases]].


==History and Symptoms==
==History and Symptoms==

Revision as of 16:14, 28 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

The hallmark of delayed puberty is lack of testicular enlargement in boys or breast development in girls in a specific stage of life. The age, in which secondary sexual characteristics are checked, is 2-2.5 SD more than the standard population average age of puberty onset; the age is 14 for boys and 13 for girls, on average. A positive family history of delayed puberty is strongly associated with delayed puberty. The most common contributing symptom of delayed puberty is anosmia or hyposmia. Less common symptoms of delayed puberty are including the symptoms related to its underlying diseases.

History and Symptoms

History

Patients with delayed puberty may have a positive history of:[1]

Klinefelter's syndrome - via Wikimedia Commons[2]
Prader-Willi syndrome - via Wikimedia Commons[3]
CHARGE syndrome, ear abnormality - via Wikimedia Commons [4]

Common Symptoms

Common symptoms of delayed puberty are including:

Less Common Symptoms

Less common symptoms of delayed puberty are including the symptoms related to its underlying diseases:

References

  1. 1.0 1.1 Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.
  2. http://smithperiod6.wikispaces.com/Klinefelter's+Syndrome [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0) or Attribution]
  3. By Fanny Cortés M1, M. Angélica Alliende R1,a, Andrés Barrios R1,2, Bianca Curotto L1,b, Lorena Santa María V1,c, Ximena Barraza O3, Ledia Troncoso A2, Cecilia Mellado S4,6, Rosa Pardo V [CC BY 4.0 (http://creativecommons.org/licenses/by/4.0)]
  4. By Kim D Blake, Chitra Prasad [CC BY 2.0 (http://creativecommons.org/licenses/by/2.0)]
  5. Marshall WA, Tanner JM (1970). "Variations in the pattern of pubertal changes in boys". Arch Dis Child. 45 (239): 13–23. PMC 2020414. PMID 5440182.
  6. Marshall WA, Tanner JM (1969). "Variations in pattern of pubertal changes in girls". Arch Dis Child. 44 (235): 291–303. PMC 2020314. PMID 5785179.
  7. Martha PM, Rogol AD, Veldhuis JD, Kerrigan JR, Goodman DW, Blizzard RM (1989). "Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys". J. Clin. Endocrinol. Metab. 69 (3): 563–70. doi:10.1210/jcem-69-3-563. PMID 2760171.
  8. Veldhuis JD, Metzger DL, Martha PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM (1997). "Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement". J. Clin. Endocrinol. Metab. 82 (10): 3414–20. doi:10.1210/jcem.82.10.4317. PMID 9329378.
  9. Rugarli EI, Ballabio A (1993). "Kallmann syndrome. From genetics to neurobiology". JAMA. 270 (22): 2713–6. PMID 8133589.
  10. Simpson JL, Rajkovic A (1999). "Ovarian differentiation and gonadal failure". Am. J. Med. Genet. 89 (4): 186–200. PMID 10727994.
  11. Smyth CM, Bremner WJ (1998). "Klinefelter syndrome". Arch. Intern. Med. 158 (12): 1309–14. PMID 9645824.
  12. Cassidy SB, Schwartz S, Miller JL, Driscoll DJ (2012). "Prader-Willi syndrome". Genet Med. 14 (1): 10–26. doi:10.1038/gim.0b013e31822bead0. PMID 22237428.
  13. "CHARGE syndrome - Genetics Home Reference".
  14. "septo-optic dysplasia - Genetics Home Reference".

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