Alanine transaminase: Difference between revisions

Jump to navigation Jump to search
Line 63: Line 63:
**[[Pralidoxime]]
**[[Pralidoxime]]
**[[Sorafenib]]
**[[Sorafenib]]
**[[Tigecycline]]
* [[Epstein-Barr Virus]]
* [[Epstein-Barr Virus]]
* [[Fatty liver]]
* [[Fatty liver]]

Revision as of 03:16, 22 January 2015

glutamic-pyruvate transaminase
Identifiers
SymbolGPT
Entrez2875
HUGO4552
OMIM138200
RefSeqNM_005309
UniProtP24298
Other data
EC number2.6.1.2
LocusChr. 8 q24.2-qter

WikiDoc Resources for Alanine transaminase

Articles

Most recent articles on Alanine transaminase

Most cited articles on Alanine transaminase

Review articles on Alanine transaminase

Articles on Alanine transaminase in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Alanine transaminase

Images of Alanine transaminase

Photos of Alanine transaminase

Podcasts & MP3s on Alanine transaminase

Videos on Alanine transaminase

Evidence Based Medicine

Cochrane Collaboration on Alanine transaminase

Bandolier on Alanine transaminase

TRIP on Alanine transaminase

Clinical Trials

Ongoing Trials on Alanine transaminase at Clinical Trials.gov

Trial results on Alanine transaminase

Clinical Trials on Alanine transaminase at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Alanine transaminase

NICE Guidance on Alanine transaminase

NHS PRODIGY Guidance

FDA on Alanine transaminase

CDC on Alanine transaminase

Books

Books on Alanine transaminase

News

Alanine transaminase in the news

Be alerted to news on Alanine transaminase

News trends on Alanine transaminase

Commentary

Blogs on Alanine transaminase

Definitions

Definitions of Alanine transaminase

Patient Resources / Community

Patient resources on Alanine transaminase

Discussion groups on Alanine transaminase

Patient Handouts on Alanine transaminase

Directions to Hospitals Treating Alanine transaminase

Risk calculators and risk factors for Alanine transaminase

Healthcare Provider Resources

Symptoms of Alanine transaminase

Causes & Risk Factors for Alanine transaminase

Diagnostic studies for Alanine transaminase

Treatment of Alanine transaminase

Continuing Medical Education (CME)

CME Programs on Alanine transaminase

International

Alanine transaminase en Espanol

Alanine transaminase en Francais

Business

Alanine transaminase in the Marketplace

Patents on Alanine transaminase

Experimental / Informatics

List of terms related to Alanine transaminase

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Alanine transaminase or ALT is a transaminase enzyme (EC 2.6.1.2). It is also known as SGPT

ALT is found in serum and in various bodily tissues, but is most commonly associated with the liver;

Function

It catalyzes the transfer of an amino group from alanine to a-ketoglutarate, the products of this reversible transamination reaction being pyruvate and glutamate.

glutamate + pyruvate Template:Unicode α-ketoglutarate + alanine
Alanine transaminase

Clinical significance

It is commonly measured clinically as a part of a diagnostic liver function test, to determine liver health. It is also called serum glutamate pyruvate transaminase (SGPT) or alanine aminotransferase (ALAT). Diagnostically, it is almost always measured in units/litre (U/L).

Elevated levels

Elevated levels of ALT often suggest the existence of other medical problems such as alcoholic or viral hepatitis, congestive heart failure, liver damage, biliary duct problems, infectious mononucleosis, or myopathy. For this reason, ALT is commonly used as a way of screening for liver problems. However, elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and ALT levels can also increase in response to strenuous physical exercise [1].

When elevated ALT levels are found in the blood, the possible underlying causes can be further narrowed down by measuring other enzymes. For example, elevated ALT levels due to liver-cell damage can be distinguished from biliary duct problems by measuring alkaline phosphatase. Also, myopathy-related ALT levels can be ruled out by measuring creatine kinase enzymes.

For years, the American Red Cross used ALT testing as part of the battery of tests to ensure the safety of its blood supply by deferring donors with elevated ALT levels. The intent was to identify donors potentially infected with Hepatitis C ("non-A non-B Hepatitis") because there was no specific test for that disease at the time. With the introduction of second generation ELISA antibody tests for Hepatitis C, the Red Cross changed the ALT policy. As of July 2003, donors previously disqualified for elevated ALT levels and no other reason may be reinstated as donors by contacting the donor counseling department of their regional Red Cross organization[2].

Differential Diagnosis of Elevated ALT

See also

References

External links


de:Alanin-Aminotransferase nl:Alanineaminotransferase sv:Alaninaminotransferas

Template:WH Template:WS