Acinic cell carcinoma natural history, complications and prognosis
|
Acinic cell carcinoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case studies |
|
Acinic cell carcinoma natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Acinic cell carcinoma natural history, complications and prognosis |
|
FDA on Acinic cell carcinoma natural history, complications and prognosis |
|
CDC on Acinic cell carcinoma natural history, complications and prognosis |
|
Acinic cell carcinoma natural history, complications and prognosis in the news |
|
Blogs on Acinic cell carcinoma natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- Parotid gland, is the most common site for acinic cell carcinoma affection.[1]
- Typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms.[2][3]
- Pain or fixation to surroundings is a sign of poor prognosis.[4]
- Nodal metastasis of acinic cell carcinoma is extremely rare.
- Another rare complication is cranial nerve VII dysfunction.
- A small minority of of acinic cell carcinoma occurs in sinonasal area or larynx.
- There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor.
- Common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast.
- Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma.[5][6][7]
Complications
- growing mass in salivary glands
- Pain
- Fixation to surrounding tissue
- Dysphagia
- Hoarseness
- Cranial nerve VII involvement
- wight loss
Prognosis
- Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.
- The worst prognosis subtype is high-grade transformation type.
- Cure of acinic cell carcinoma prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.
- Sever findings have suggested that a protracted cilinical course with reccurence occured years or even decades after initial diagnosis.
- The prognostic factors are :
- Age
- Pain
- Gender
- Race
- Perivious inadequate treatment
- Extent of disease.
- Invasion of the skull base.
References
- ↑ "kankerregister.org" (PDF).
- ↑ Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
- ↑ Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
- ↑ Ripamonti, Carla B; Colombo, Mara; Mondini, Patrizia; Siranoush, Manoukian; Peissel, Bernard; Bernard, Loris; Radice, Paolo; Carcangiu, Maria Luisa (2013). "First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report". BMC Cancer. 13 (1). doi:10.1186/1471-2407-13-46. ISSN 1471-2407.
- ↑ Slater, Lee (2013). "Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia". Journal of Oral and Maxillofacial Surgery. 71 (4): 655. doi:10.1016/j.joms.2012.12.022. ISSN 0278-2391.
- ↑ Gnepp, Douglas R.; Schroeder, Walter; Heffner, Dennis (1989). "Synchronous tumors arising in a single major salivary gland". Cancer. 63 (6): 1219–1224. doi:10.1002/1097-0142(19890315)63:6<1219::AID-CNCR2820630631>3.0.CO;2-Y. ISSN 0008-543X.
- ↑ Jia, Yu-Lin; Bishwo, Sedhain P.; Nie, Xiu; Chen, Li-Li (2012). "Synchronous Bilateral Multifocal Acinic Cell Carcinoma of Parotid Gland: Case Report and Review of the Literature". Journal of Oral and Maxillofacial Surgery. 70 (10): e574–e580. doi:10.1016/j.joms.2012.06.006. ISSN 0278-2391.