Acinic cell carcinoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]


Parotid gland, is the most common site for acinic cell carcinoma affection. typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms. pain or fixation to surroundings is a sign of poor prognosis. nodal metastasis of acinic cell carcinoma is extremely rare. another rare complication is cranial nerve VII dysfunction. a small minority of of acinic cell carcinoma occurs in sinonasal area or larynx. there is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor. common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast. Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma. the prognostic factors are ge, pain, gender, race, previous inadequate treatment, extent of disease, invasion of the skull base.

Natural History, Complications, and Prognosis

Natural History



  • Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.[10][11]
  • The worst prognosis subtype is high-grade transformation type.
  • Acinic cell carcinoma prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.[12][13]
  • Sever findings have suggested that a protracted clinical course with occurred years or even decades after initial diagnosis.
  • The prognostic factors are :[14]
    • Age
    • Pain
    • Gender
    • Race
    • Previous inadequate treatment
    • Extent of disease
    • Invasion of the skull base.


  1. "" (PDF).
  2. Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
  3. Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
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  5. Slater, Lee (2013). "Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia". Journal of Oral and Maxillofacial Surgery. 71 (4): 655. doi:10.1016/j.joms.2012.12.022. ISSN 0278-2391.
  6. Gnepp, Douglas R.; Schroeder, Walter; Heffner, Dennis (1989). "Synchronous tumors arising in a single major salivary gland". Cancer. 63 (6): 1219–1224. doi:10.1002/1097-0142(19890315)63:6<1219::AID-CNCR2820630631>3.0.CO;2-Y. ISSN 0008-543X.
  7. Jia, Yu-Lin; Bishwo, Sedhain P.; Nie, Xiu; Chen, Li-Li (2012). "Synchronous Bilateral Multifocal Acinic Cell Carcinoma of Parotid Gland: Case Report and Review of the Literature". Journal of Oral and Maxillofacial Surgery. 70 (10): e574–e580. doi:10.1016/j.joms.2012.06.006. ISSN 0278-2391.
  8. Sen, Rajeev; Bhutani, Namita; Kamboj, Jashanpreet; Dahiya, Sakshi (2018). "Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype". Annals of Medicine and Surgery. 35: 137–140. doi:10.1016/j.amsu.2018.09.030. ISSN 2049-0801.
  9. Ilayaraja, Vadivel; Prasad, H; Anuthama, Krishnamurthy; Sruthi, Ranganath (2014). "Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation". Journal of Oral and Maxillofacial Pathology. 18 (1): 97. doi:10.4103/0973-029X.131925. ISSN 0973-029X.
  10. Patel, Neal R.; Sanghvi, Saurin; Khan, Mohemmed N.; Husain, Qasim; Baredes, Soly; Eloy, Jean Anderson (2013). "Demographic trends and disease‐specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases". The Laryngoscope. 124 (1): 172–178. doi:10.1002/lary.24231. ISSN 0023-852X.
  11. Perzin, Karl H.; Livolsi, Virginia A. (1979). "Acinic cell carcinomas arising in salivary glands. A clinicopathologic study". Cancer. 44 (4): 1434–1457. doi:10.1002/1097-0142(197910)44:4<1434::AID-CNCR2820440439>3.0.CO;2-H. ISSN 0008-543X.
  12. Kane, W. J.; McCaffrey, T. V.; Olsen, K. D.; Lewis, J. E. (1991). "Primary Parotid Malignancies: A Clinical and Pathologic Review". Archives of Otolaryngology - Head and Neck Surgery. 117 (3): 307–315. doi:10.1001/archotol.1991.01870150075010. ISSN 0886-4470.
  13. Eneroth, Carl-Magnus; Jakobsson, Per Å.; Blanck, Carl (1966). "Acinic cell carcinoma of the parotid gland". Cancer. 19 (12): 1761–1772. doi:10.1002/1097-0142(196612)19:12<1761::AID-CNCR2820191202>3.0.CO;2-#. ISSN 0008-543X.
  14. Neff, Brian; Moore, Eric; Link, Michael; Carlson, Matthew; Breen, Joseph; Driscoll, Colin (2012). "Skull Base Involvement by Acinic Cell Carcinoma of the Parotid Gland". Journal of Neurological Surgery Part B: Skull Base. 73 (06): 371–378. doi:10.1055/s-0032-1322797. ISSN 2193-6331.

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