Acinic cell carcinoma natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
* Parotid gland, is the most common site for acinic cell carcinoma affection.{{cite web|url=https://kankerregister.org/media/docs/StK_publicatie.pdf|title=kankerregister.org|format=|work=|accessdate=}} | * Parotid gland, is the most common site for acinic cell carcinoma affection.<ref name="urlkankerregister.org">{{cite web |url=https://kankerregister.org/media/docs/StK_publicatie.pdf |title=kankerregister.org |author= |authorlink= |coauthors= |date= |format= |work= |publisher= |pages= |language= |archiveurl= |archivedate= |quote= |accessdate=}}</ref> | ||
* Typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms. | * Typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms.<ref name="LewisOlsen1991">{{cite journal|last1=Lewis|first1=Jean E.|last2=Olsen|first2=Kerry D.|last3=Weiland|first3=Louis H.|title=Acinic cell carcinoma. Clinicopathologic review|journal=Cancer|volume=67|issue=1|year=1991|pages=172–179|issn=0008-543X|doi=10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X}}</ref><ref name="NeskeyKlein2013">{{cite journal|last1=Neskey|first1=David M.|last2=Klein|first2=Jonah D.|last3=Hicks|first3=Stephanie|last4=Garden|first4=Adam S.|last5=Bell|first5=Diana M.|last6=El-Naggar|first6=Adel K.|last7=Kies|first7=Merrill S.|last8=Weber|first8=Randal S.|last9=Kupferman|first9=Michael E.|title=Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma|journal=JAMA Otolaryngology–Head & Neck Surgery|volume=139|issue=11|year=2013|pages=1195|issn=2168-6181|doi=10.1001/jamaoto.2013.4728}}</ref> | ||
* Pain or fixation to surroundings is a sign of poor prognosis. | * Pain or fixation to surroundings is a sign of poor prognosis.<ref name="RipamontiColombo2013">{{cite journal|last1=Ripamonti|first1=Carla B|last2=Colombo|first2=Mara|last3=Mondini|first3=Patrizia|last4=Siranoush|first4=Manoukian|last5=Peissel|first5=Bernard|last6=Bernard|first6=Loris|last7=Radice|first7=Paolo|last8=Carcangiu|first8=Maria Luisa|title=First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report|journal=BMC Cancer|volume=13|issue=1|year=2013|issn=1471-2407|doi=10.1186/1471-2407-13-46}}</ref> | ||
* Nodal metastasis of acinic cell carcinoma is extremely rare. | * Nodal metastasis of acinic cell carcinoma is extremely rare. | ||
* Another rare complication is cranial nerve VII dysfunction. | * Another rare complication is cranial nerve VII dysfunction. | ||
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* There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor. | * There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor. | ||
* Common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast. | * Common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast. | ||
* Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma. | * Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma.<ref name="Slater2013">{{cite journal|last1=Slater|first1=Lee|title=Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia|journal=Journal of Oral and Maxillofacial Surgery|volume=71|issue=4|year=2013|pages=655|issn=02782391|doi=10.1016/j.joms.2012.12.022}}</ref> | ||
===Complications=== | ===Complications=== |
Revision as of 15:09, 16 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- Parotid gland, is the most common site for acinic cell carcinoma affection.[1]
- Typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms.[2][3]
- Pain or fixation to surroundings is a sign of poor prognosis.[4]
- Nodal metastasis of acinic cell carcinoma is extremely rare.
- Another rare complication is cranial nerve VII dysfunction.
- A small minority of of acinic cell carcinoma occurs in sinonasal area or larynx.
- There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor.
- Common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast.
- Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma.[5]
Complications
- growing mass in salivary glands
- Pain
- Fixation to surrounding tissue
- Dysphagia
- Hoarseness
- Cranial nerve VII involvement
- wight loss
Prognosis
- Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.
- The worst prognosis subtype is high-grade transformation type.
- Cure of acinic cell carcinoma prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.
- Sever findings have suggested that a protracted cilinical course with reccurence occured years or even decades after initial diagnosis.
- The prognostic factors are :
- Age
- Pain
- Gender
- Race
- Perivious inadequate treatment
- Extent of disease.
- Invasion of the skull base.
References
- ↑ "kankerregister.org" (PDF).
- ↑ Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
- ↑ Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
- ↑ Ripamonti, Carla B; Colombo, Mara; Mondini, Patrizia; Siranoush, Manoukian; Peissel, Bernard; Bernard, Loris; Radice, Paolo; Carcangiu, Maria Luisa (2013). "First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report". BMC Cancer. 13 (1). doi:10.1186/1471-2407-13-46. ISSN 1471-2407.
- ↑ Slater, Lee (2013). "Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia". Journal of Oral and Maxillofacial Surgery. 71 (4): 655. doi:10.1016/j.joms.2012.12.022. ISSN 0278-2391.