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Natural History, Complications & Prognosis
__NOTOC__
{{Swathi}}
{{Acinic cell carcinoma}}


*Acinic cell carcinoma is a slow growing tumor  
{{CMG}}; {{AE}} {{RG}}
*Tumor may affect the facial nerve or other adjacent tissues depending on its location
 
*Prognosis is most favorable when the parotid gland is involved
==Overview==
*Progression of acinic cell carcinoma is slow but it may involve adjacent tissues if not treated adequately.  
[[Parotid gland]], is the most common site for [[acinic cell carcinoma]] affection. typically, [[acinic cell carcinoma]] is a slow growing mass, lacking other [[Symptom|symptoms]]. pain or fixation to surroundings is  a sign of poor prognosis. nodal [[metastasis]] of [[acinic cell carcinoma]] is extremely rare. another rare complication is [[Facial nerve|cranial nerve VII]] dysfunction. a small minority of of [[acinic cell carcinoma]] occurs in [[Sinonasal undifferentiated carcinoma|sinonasal]] area or [[larynx]]. there is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor. common sites for non-salivary acinic cell carcinoma is [[lacrimal gland]], [[pancreas]], and [[breast]]. [[Acinic cell carcinoma]] in pancreas are so called as [[acinar cell carcinoma]]. the prognostic factors are ge, pain, gender, race, previous inadequate treatment, extent of disease, invasion of the [[skull]] base.<br />
*Acinic cell carcinoma can spread to adjacent organs and eventually be lethal if not intervened on time.  
==Natural History, Complications, and Prognosis==
*The prognosis is more favorable when the tumor is in a major salivary gland; the parotid gland is most favorable, followed by the submandibular gland
 
*The least favorable primary sites are the sublingual and minor salivary glands  
===Natural History===
*Large bulky tumors or high-grade tumors carry a least favorable or poor prognosis and may best be treated by surgical resection combined with postoperative radiation therapy
 
*[[Parotid gland]], is the most common site for [[acinic cell carcinoma]] affection.<ref name="urlkankerregister.org">{{cite web |url=https://kankerregister.org/media/docs/StK_publicatie.pdf |title=kankerregister.org |author= |authorlink= |coauthors= |date= |format= |work= |publisher= |pages= |language= |archiveurl= |archivedate= |quote= |accessdate=}}</ref>
* Typically, [[acinic cell carcinoma]] is a slow growing mass, lacking other [[Symptom|symptoms]].<ref name="LewisOlsen1991">{{cite journal|last1=Lewis|first1=Jean E.|last2=Olsen|first2=Kerry D.|last3=Weiland|first3=Louis H.|title=Acinic cell carcinoma. Clinicopathologic review|journal=Cancer|volume=67|issue=1|year=1991|pages=172–179|issn=0008-543X|doi=10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X}}</ref><ref name="NeskeyKlein2013">{{cite journal|last1=Neskey|first1=David M.|last2=Klein|first2=Jonah D.|last3=Hicks|first3=Stephanie|last4=Garden|first4=Adam S.|last5=Bell|first5=Diana M.|last6=El-Naggar|first6=Adel K.|last7=Kies|first7=Merrill S.|last8=Weber|first8=Randal S.|last9=Kupferman|first9=Michael E.|title=Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma|journal=JAMA Otolaryngology–Head & Neck Surgery|volume=139|issue=11|year=2013|pages=1195|issn=2168-6181|doi=10.1001/jamaoto.2013.4728}}</ref>
* Pain or fixation to surroundings is a sign of poor prognosis.<ref name="RipamontiColombo2013">{{cite journal|last1=Ripamonti|first1=Carla B|last2=Colombo|first2=Mara|last3=Mondini|first3=Patrizia|last4=Siranoush|first4=Manoukian|last5=Peissel|first5=Bernard|last6=Bernard|first6=Loris|last7=Radice|first7=Paolo|last8=Carcangiu|first8=Maria Luisa|title=First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report|journal=BMC Cancer|volume=13|issue=1|year=2013|issn=1471-2407|doi=10.1186/1471-2407-13-46}}</ref>
* Nodal [[metastasis]] of [[acinic cell carcinoma]] is extremely rare.
* Another rare complication is [[Facial nerve|cranial nerve VII]] dysfunction.
* A small minority of of [[acinic cell carcinoma]] occurs in [[Sinonasal undifferentiated carcinoma|sinonasal]] area or [[larynx]].
* There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor.<ref name="Slater2013">{{cite journal|last1=Slater|first1=Lee|title=Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia|journal=Journal of Oral and Maxillofacial Surgery|volume=71|issue=4|year=2013|pages=655|issn=02782391|doi=10.1016/j.joms.2012.12.022}}</ref><ref name="GneppSchroeder1989">{{cite journal|last1=Gnepp|first1=Douglas R.|last2=Schroeder|first2=Walter|last3=Heffner|first3=Dennis|title=Synchronous tumors arising in a single major salivary gland|journal=Cancer|volume=63|issue=6|year=1989|pages=1219–1224|issn=0008-543X|doi=10.1002/1097-0142(19890315)63:6<1219::AID-CNCR2820630631>3.0.CO;2-Y}}</ref><ref name="JiaBishwo2012">{{cite journal|last1=Jia|first1=Yu-Lin|last2=Bishwo|first2=Sedhain P.|last3=Nie|first3=Xiu|last4=Chen|first4=Li-Li|title=Synchronous Bilateral Multifocal Acinic Cell Carcinoma of Parotid Gland: Case Report and Review of the Literature|journal=Journal of Oral and Maxillofacial Surgery|volume=70|issue=10|year=2012|pages=e574–e580|issn=02782391|doi=10.1016/j.joms.2012.06.006}}</ref>
* Common sites for non-salivary acinic cell carcinoma is [[lacrimal gland]], [[pancreas]], and [[breast]].<ref name="SenBhutani2018">{{cite journal|last1=Sen|first1=Rajeev|last2=Bhutani|first2=Namita|last3=Kamboj|first3=Jashanpreet|last4=Dahiya|first4=Sakshi|title=Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype|journal=Annals of Medicine and Surgery|volume=35|year=2018|pages=137–140|issn=20490801|doi=10.1016/j.amsu.2018.09.030}}</ref>
*[[Acinic cell carcinoma]] in pancreas are so called as [[acinar cell carcinoma]].<ref name="IlayarajaPrasad2014">{{cite journal|last1=Ilayaraja|first1=Vadivel|last2=Prasad|first2=H|last3=Anuthama|first3=Krishnamurthy|last4=Sruthi|first4=Ranganath|title=Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation|journal=Journal of Oral and Maxillofacial Pathology|volume=18|issue=1|year=2014|pages=97|issn=0973-029X|doi=10.4103/0973-029X.131925}}</ref>
 
===Complications===
 
* growing mass in [[salivary gland]]<nowiki/>s
* Pain
* Fixation to surrounding tissue
*[[Dysphagia]]
*[[Hoarseness]]
*[[Facial nerve]] involvement
* wight loss
 
===Prognosis===
 
* Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.<ref name="PatelSanghvi2013">{{cite journal|last1=Patel|first1=Neal R.|last2=Sanghvi|first2=Saurin|last3=Khan|first3=Mohemmed N.|last4=Husain|first4=Qasim|last5=Baredes|first5=Soly|last6=Eloy|first6=Jean Anderson|title=Demographic trends and disease‐specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases|journal=The Laryngoscope|volume=124|issue=1|year=2013|pages=172–178|issn=0023-852X|doi=10.1002/lary.24231}}</ref><ref name="PerzinLivolsi1979">{{cite journal|last1=Perzin|first1=Karl H.|last2=Livolsi|first2=Virginia A.|title=Acinic cell carcinomas arising in salivary glands. A clinicopathologic study|journal=Cancer|volume=44|issue=4|year=1979|pages=1434–1457|issn=0008-543X|doi=10.1002/1097-0142(197910)44:4<1434::AID-CNCR2820440439>3.0.CO;2-H}}</ref>
* The worst prognosis subtype is high-grade transformation type.
*[[Acinic cell carcinoma]] prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.<ref name="KaneMcCaffrey1991">{{cite journal|last1=Kane|first1=W. J.|last2=McCaffrey|first2=T. V.|last3=Olsen|first3=K. D.|last4=Lewis|first4=J. E.|title=Primary Parotid Malignancies: A Clinical and Pathologic Review|journal=Archives of Otolaryngology - Head and Neck Surgery|volume=117|issue=3|year=1991|pages=307–315|issn=0886-4470|doi=10.1001/archotol.1991.01870150075010}}</ref><ref name="EnerothJakobsson1966">{{cite journal|last1=Eneroth|first1=Carl-Magnus|last2=Jakobsson|first2=Per Å.|last3=Blanck|first3=Carl|title=Acinic cell carcinoma of the parotid gland|journal=Cancer|volume=19|issue=12|year=1966|pages=1761–1772|issn=0008-543X|doi=10.1002/1097-0142(196612)19:12<1761::AID-CNCR2820191202>3.0.CO;2-#}}</ref>
* Sever findings have suggested that a protracted clinical course with occurred years or even decades after initial diagnosis.
* The prognostic factors are :<ref name="NeffMoore2012">{{cite journal|last1=Neff|first1=Brian|last2=Moore|first2=Eric|last3=Link|first3=Michael|last4=Carlson|first4=Matthew|last5=Breen|first5=Joseph|last6=Driscoll|first6=Colin|title=Skull Base Involvement by Acinic Cell Carcinoma of the Parotid Gland|journal=Journal of Neurological Surgery Part B: Skull Base|volume=73|issue=06|year=2012|pages=371–378|issn=2193-6331|doi=10.1055/s-0032-1322797}}</ref>
** Age
** Pain
** Gender
** Race
** Previous inadequate treatment
** Extent of disease
** Invasion of the skull base.
 
==References==
{{Reflist|2}}
 
{{WH}}
{{WS}}
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Latest revision as of 17:01, 2 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Parotid gland, is the most common site for acinic cell carcinoma affection. typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms. pain or fixation to surroundings is a sign of poor prognosis. nodal metastasis of acinic cell carcinoma is extremely rare. another rare complication is cranial nerve VII dysfunction. a small minority of of acinic cell carcinoma occurs in sinonasal area or larynx. there is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor. common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast. Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma. the prognostic factors are ge, pain, gender, race, previous inadequate treatment, extent of disease, invasion of the skull base.

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

  • Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.[10][11]
  • The worst prognosis subtype is high-grade transformation type.
  • Acinic cell carcinoma prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.[12][13]
  • Sever findings have suggested that a protracted clinical course with occurred years or even decades after initial diagnosis.
  • The prognostic factors are :[14]
    • Age
    • Pain
    • Gender
    • Race
    • Previous inadequate treatment
    • Extent of disease
    • Invasion of the skull base.

References

  1. ↑ "kankerregister.org" (PDF).
  2. ↑ Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
  3. ↑ Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
  4. ↑ Ripamonti, Carla B; Colombo, Mara; Mondini, Patrizia; Siranoush, Manoukian; Peissel, Bernard; Bernard, Loris; Radice, Paolo; Carcangiu, Maria Luisa (2013). "First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report". BMC Cancer. 13 (1). doi:10.1186/1471-2407-13-46. ISSN 1471-2407.
  5. ↑ Slater, Lee (2013). "Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia". Journal of Oral and Maxillofacial Surgery. 71 (4): 655. doi:10.1016/j.joms.2012.12.022. ISSN 0278-2391.
  6. ↑ Gnepp, Douglas R.; Schroeder, Walter; Heffner, Dennis (1989). "Synchronous tumors arising in a single major salivary gland". Cancer. 63 (6): 1219–1224. doi:10.1002/1097-0142(19890315)63:6<1219::AID-CNCR2820630631>3.0.CO;2-Y. ISSN 0008-543X.
  7. ↑ Jia, Yu-Lin; Bishwo, Sedhain P.; Nie, Xiu; Chen, Li-Li (2012). "Synchronous Bilateral Multifocal Acinic Cell Carcinoma of Parotid Gland: Case Report and Review of the Literature". Journal of Oral and Maxillofacial Surgery. 70 (10): e574–e580. doi:10.1016/j.joms.2012.06.006. ISSN 0278-2391.
  8. ↑ Sen, Rajeev; Bhutani, Namita; Kamboj, Jashanpreet; Dahiya, Sakshi (2018). "Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype". Annals of Medicine and Surgery. 35: 137–140. doi:10.1016/j.amsu.2018.09.030. ISSN 2049-0801.
  9. ↑ Ilayaraja, Vadivel; Prasad, H; Anuthama, Krishnamurthy; Sruthi, Ranganath (2014). "Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation". Journal of Oral and Maxillofacial Pathology. 18 (1): 97. doi:10.4103/0973-029X.131925. ISSN 0973-029X.
  10. ↑ Patel, Neal R.; Sanghvi, Saurin; Khan, Mohemmed N.; Husain, Qasim; Baredes, Soly; Eloy, Jean Anderson (2013). "Demographic trends and disease‐specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases". The Laryngoscope. 124 (1): 172–178. doi:10.1002/lary.24231. ISSN 0023-852X.
  11. ↑ Perzin, Karl H.; Livolsi, Virginia A. (1979). "Acinic cell carcinomas arising in salivary glands. A clinicopathologic study". Cancer. 44 (4): 1434–1457. doi:10.1002/1097-0142(197910)44:4<1434::AID-CNCR2820440439>3.0.CO;2-H. ISSN 0008-543X.
  12. ↑ Kane, W. J.; McCaffrey, T. V.; Olsen, K. D.; Lewis, J. E. (1991). "Primary Parotid Malignancies: A Clinical and Pathologic Review". Archives of Otolaryngology - Head and Neck Surgery. 117 (3): 307–315. doi:10.1001/archotol.1991.01870150075010. ISSN 0886-4470.
  13. ↑ Eneroth, Carl-Magnus; Jakobsson, Per Å.; Blanck, Carl (1966). "Acinic cell carcinoma of the parotid gland". Cancer. 19 (12): 1761–1772. doi:10.1002/1097-0142(196612)19:12<1761::AID-CNCR2820191202>3.0.CO;2-#. ISSN 0008-543X.
  14. ↑ Neff, Brian; Moore, Eric; Link, Michael; Carlson, Matthew; Breen, Joseph; Driscoll, Colin (2012). "Skull Base Involvement by Acinic Cell Carcinoma of the Parotid Gland". Journal of Neurological Surgery Part B: Skull Base. 73 (06): 371–378. doi:10.1055/s-0032-1322797. ISSN 2193-6331.

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