Menopause laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Rahmah Al-Edresi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of menopause include an elevated Follicle Stimulating Hormone > 40 mIU/mL, decreased estradiol level <20 pg/ml, and decreased serum of the Anti-Mullerian Hormone level < 0.20 ng/ml. In addition to other blood tests that are related to premature menopause such as positive karyotype test of FMR1 in Fragile X syndrome and decrease of Thyroid-stimulating hormone.
laboratory findings
Laboratory findings consistent with the diagnosis of menopause include:
- An elevated serum of Follicle Stimulating Hormone (FSH) > 40 mIU/mL is diagnostic of menopause, but an elevated FSH level on two blood samples is diagnostic of premature menopause with intervals of about 4–6 weeks between samples.[1]
- A decreased serum of the AMH level < 0.20 ng/ml is normal in postmenopausal women, but decreased serum of the Anti-Mullerian Hormone level is a diagnostic test of premature menopause[2]
- A decreased estradiol level <20 pg/ml.
- Positive of karyotype analysis of FMR1 in Fragile X syndrome case.
- Decrease of Thyroid-stimulating hormone (TSH) in thyroid dysfunction case.[3]
References
- ↑ Burger HG (1994). "Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition--an analysis of FSH, oestradiol and inhibin". Eur J Endocrinol. 130 (1): 38–42. doi:10.1530/eje.0.1300038. PMID 8124478.
- ↑ Visser JA, Schipper I, Laven JS, Themmen AP (2012). "Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency". Nat Rev Endocrinol. 8 (6): 331–41. doi:10.1038/nrendo.2011.224. PMID 22231848.
- ↑ Torrealday S, Kodaman P, Pal L (2017). "Premature Ovarian Insufficiency - an update on recent advances in understanding and management". F1000Res. 6: 2069. doi:10.12688/f1000research.11948.1. PMC 5710309. PMID 29225794.