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Septic arthritis resident survival guide:

Complete diagnostic approach:

Common Presentation

Symptoms in newborns or infants:

  • Cries when infected joint is moved (e.g. diaper change causes crying if hip joint is infected)
  • Fever
  • Inability to move the limb with the infected joint (pseudoparalysis)
  • Irritability

Symptoms in children and adults:

Less common Presentation

 
 
 
 
 
 
 
 

Focused History

  • Intravenous drug use
  • Sexual activity
  • Terminal complement deficiency
  • Dog or cat bite
  • Ingestion of unpasteurized dairy products
  • Nail through shoe
  • Soil exposure/gardening
  • Soil or dust exposure containing decomposed wood

(north-central and southern United States)

  • Southwestern United States, Central and South America

(primary respiratory illness)

  • Cleaning fish tank
 
 
 
 
 
 
 
 

Physical Examination

Appearance of the Patient

Vital Signs

Skin

  • Warmth over the joint

Extremities

Most commonly involves knee > hip > shoulder > ankle.[2] Other joints such as sacroiliac joint (~10%), sternoclavicular or costoclavicular joints may be involved in patient with history of intravenous drug abuse (IVDA), penetrating trauma, animal or human bites and local steroid injections.

  • Swelling of the joint that involved
  • Decreased range of motion such as pseudo paralysis
  • Patient hold the hip in flexed and externally rotated position if SA involving hip.
  • If child, unwillingness to bear weight on the affected joint (antalgic gait)
 
 
 
 
 
 
 
 

Laboratory Workup

 
 
 
 
 
 
 
 

Imaging Study

Plain radiographs of swollen joints

  • Swelling of the joint capsule and soft tissue around the joint
  • Fat pad displacement
  • Joint space widening due to localized edema and effusion.[3][4][5]

Computed tomography (CT)

  • Visualization of joint effusion
  • Soft tissue swelling
  • Para-articular abscesses
  • Joint space widening due to localized edema, bone erosions, foci of osteitis, and scleroses.[6][4]


Magnetic resonance imaging (MRI)

  • Synovial enhancement
  • Perisynovial edema
  • Joint effusion
  • Signal abnormalities in the bone marrow
 
 
 
 
 
 
 
 

Other Investigation

PCR

Arthrocentesis

  • In the presence of joint effusion to differentiate between different causes of arthritis[7]
 
 
  1. Goldenberg DL (1998) Septic arthritis. Lancet 351 (9097):197-202. DOI:10.1016/S0140-6736(97)09522-6 PMID: 9449882
  2. Barton LL, Dunkle LM, Habib FH (1987) Septic arthritis in childhood. A 13-year review. Am J Dis Child 141 (8):898-900. PMID: 3498362
  3. Jaramillo D, Treves ST, Kasser JR, Harper M, Sundel R, Laor T (1995) Osteomyelitis and septic arthritis in children: appropriate use of imaging to guide treatment. AJR Am J Roentgenol 165 (2):399-403. DOI:10.2214/ajr.165.2.7618566 PMID: 7618566
  4. 4.0 4.1 Shirtliff ME, Mader JT (2002) Acute septic arthritis. Clin Microbiol Rev 15 (4):527-44. PMID: 12364368
  5. Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML (2011) Approach to septic arthritis. Am Fam Physician 84 (6):653-60. PMID: 21916390
  6. Seltzer SE (1984) Value of computed tomography in planning medical and surgical treatment of chronic osteomyelitis. J Comput Assist Tomogr 8 (3):482-7. PMID: 6725696
  7. Goldenberg DL, Cohen AS (1978). "Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease". Medicine (Baltimore). 57 (3): 239–52. PMID 642792.