Leg swelling

Leg swelling

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [2]

Synonyms and keywords: lower extremity swelling

Overview

Leg selling is a non-specific finding on physical examination. Leg swelling often occurs secondary to drugs, obstruction to venous or lymphatic outflow, and leakage from vessels.

Differential Diagnosis of Causes of Leg swelling

Complete Differential Diagnosis of the Causes of Leg swelling

(By organ system)

Cardiovascular	Arteriovenous Fistula , Cardiomyopathy, Chronic Venous insufficiency , Constrictive pericarditis, Cor pulmonale, Ischemia , Kawasaki disease, Kawasaki syndrome, left ventricular failure, May-Thurner syndrome, Mitral Stenosis , Phlebitis, Phlebothrombosis , Phlegmasia cerulea dolens, Postischemic , Post-thrombotic syndrome, Systemic vasculitis , Thrombophlebitis , Thrombosis in the vena cava , Uncompensated hypertension , Varicosis , Venous insufficiency
Chemical / poisoning	No underlying causes
Dermatologic	Angioneurotic edema , erysipelas, Erythema nodosum, Erythromelalgia, hereditary lymphedema, Hypertrophic osteopathy, idiopathic edema, ishemic leg edemas, Lymphedema, Sebaceous cyst, Secondary lymphatic blockage , Thrombophlebitis, Phlebothrombosis , Varicosis , Elephantiasis due to filaria
Drug Side Effect	Abacavir, Acebutolol (patient information), Acitretin (patient information), Acyclovir (patient information), Adalimumab Injection (patient information), Adderall, Albuterol (patient information), Alfuzosin (patient information), Aliskiren, Aliskiren (patient information), Aliskiren (patient information), Alitretinoin (patient information), Amantadine (patient information), Amiodarone, Amlodipine (patient information), Amlodipine and Benazepril (patient information), Anagrelide (patient information), Anastrozole (patient information), Aripiprazole (patient information), Asparaginase (patient information), Atenolol (patient information), Atorvastatin (patient information), Azithromycin, Benazepril (patient information), Bepridil (patient information), Bicalutamide (patient information), Bisoprolol (patient information), Bortezomib (patient information), Candesartan (patient information), Capecitabine (patient information), Carboplatin (patient information), Carmustine (patient information), Carvedilol (patient information), Caspofungin, Chondroitin sulfate, Cidofovir Injection (patient information), Cilostazol (patient information), Ciprofloxacin, Clarithromycin, Clopidogrel (patient information), Cyanocobalamin Injection (patient information), Cyclosporine (patient information), Cytomegalovirus Immune Globulin Intravenous Injection (patient information), Danazol (patient information), Deferasirox (patient information), Dexamethasone Oral (patient information), Diclofenac and Misoprostol (patient information), Didanosine (patient information), Diethylpropion (patient information), Diflunisal, Digoxin Oral (patient information), Diltiazem (patient information), Diphenoxylate and Atropine (patient information), Disopyramide (patient information), Doxazosin (patient information), Enalapril (patient information), Enalapril and Felodipine (patient information), Enalapril and Hydrochlorothiazide (patient information), Eprosartan (patient information), Esomeprazole (patient information), Eszopiclone (patient information), Etanercept Injection (patient information), Etidronate (patient information), Etodolac (patient information), Exenatide Injection (patient information), Ezetimibe (patient information), Famotidine (patient information), Felodipine (patient information), Fenoprofen (patient information), Fexofenadine (patient information), Fexofenadine and Pseudoephedrine (patient information), Fluconazole (patient information), Fluorouracil (patient information), Flutamide (patient information), Fluticasone and Salmeterol Oral Inhalation (patient information), Fluticasone Oral Inhalation (patient information), Fluvastatin (patient information), Formoterol (patient information), Fosinopril (patient information), Gabapentin, Ganciclovir (patient information), Gatifloxacin (patient information), Gefitinib (patient information), Gemcitabine Hydrochloride (patient information), Glatiramer Injection (patient information), Histrelin Injection (patient information), Hydrocortisone Injection (patient information), Hydrocortisone Oral (patient information), Hydrocortisone, Neomycin, and Polymyxin (patient information), Hydroxyurea (patient information), Imatinib (patient information), Imiglucerase Injection (patient information), Indomethacin (patient information), Infliximab Injection (patient information), Insulin Glulisine (rDNA origin) Injection (patient information), Interferon Beta-1b Injection (patient information), Interferon Gamma-1b Injection (patient information), Ipratropium and Albuterol Inhalation (patient information), Ipratropium Oral Inhalation (patient information), Irbesartan (patient information), Isradipine (patient information), Labetalol Oral (patient information), Lamotrigine (patient information), Lansoprazole/clarithromycin/amoxicillin (patient information), Letrozole (patient information), Leuprolide (patient information), Levocarnitine Injection (patient information), Levodopa and Carbidopa (patient information), Levofloxacin Injection (patient information), Levofloxacin Oral (patient information), Lisinopril (patient information), Lisinopril and Hydrochlorothiazide (patient information), Lithium (patient information), Lomefloxacin (patient information), Loratadine (patient information), Losartan (patient information), Losartan and Hydrochlorothiazide (patient information), Lovastatin (patient information), Meclofenamate (patient information), Medroxyprogesterone (patient information), Mefenamic acid, Mesalamine (patient information), Metoclopramide Hydrochloride Injection (patient information), Metoprolol, Mitomycin (patient information), Modafinil (patient information), Moexipril (patient information), Mycophenolate (patient information), Nabumetone (patient information), Nadolol (patient information), Natalizumab injection (patient information), Nevirapine (patient information), Nicardipine (patient information), Nifedipine (patient information), Nisoldipine (patient information), Norethindrone (patient information), Norfloxacin (patient information), Olanzapine (patient information), Olmesartan (patient information), Omeprazole (patient information), Ondansetron (patient information), Oxandrolone, Oxaprozin, Oxcarbazepine (patient information), Oxiconazole (patient information), Oxybutynin (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Pamidronate injection (patient information), Pancrelipase, Pegaspargase (patient information), Peginterferon alfa-2a (patient information), Peginterferon alfa-2b (patient information), Perindopril (patient information), Phenazopyridine (patient information), Phenelzine (patient information), Phentermine (patient information), Phenytoin oral (patient information), Pimecrolimus topical (patient information), Pindolol (patient information), Piroxicam (patient information), Posaconazole (patient information), Pramipexole (patient information), Pramoxine (patient information), Pravastatin (patient information), Prednisolone, Prednisone, Pregabalin (patient information), Propranolol Oral (patient information), Propylthiouracil (patient information), Quinapril (patient information), Raloxifene, Ramipril, Ribavirin (patient information), Risedronate (patient information), Ritonavir (patient information), Ropinirole (patient information), Rosuvastatin (patient information), Salsalate (patient information), Sargramostim injection (patient information), Sibutramine (patient information), Simvastatin (patient information), Sirolimus (patient information), Sodium bicarbonate (patient information), Solifenacin (patient information), Sotalol (patient information), Sulfinpyrazone (patient information), Sulindac (patient information), Sunitinib (patient information), Tacrolimus topical (patient information), Tamoxifen (patient information), Tamsulosin (patient information), Telithromycin (patient information), Telmisartan (patient information), Temozolomide (patient information), Terazosin (patient information), Testosterone Buccal (patient information), Testosterone Topical (patient information), Thioguanine (patient information), Tiludronate (patient information), Timolol Oral (patient information), Tinidazole (patient information), Tolmetin, Trandolapril (patient information), Tranylcypromine (patient information), Trazodone (patient information), Triamcinolone Oral (patient information), Triamcinolone Topical (patient information), Valganciclovir (patient information), Valsartan (patient information), Vardenafil (patient information), Verapamil, Verapamil and Trandolapril (patient information), Voriconazole (patient information), Vorinostat (patient information), Zanamivir Inhalation (patient information),Zoledronic Acid Injection (patient information)|-
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, Diabetic nephropathy, Graves' Disease, hyperaldosteronism, hyperthyroidism, hypothyroidism, Myxedema
Environmental	heat, Allergy, Bee sting
Gastroenterologic	Ascites, exudative enteropathy, Hernia, Hypoalbuminemia, Liver disease with synthesis disorder or portal vein stasis , Malabsorption , Protein-Losing Enteropathy
Genetic	Turner's Syndrome
Hematologic	Deep Vein Thrombosis, Pernicious anemia
Iatrogenic	No underlying causes
Infectious Disease	Adenitis, Bubonic plague, Cellulitis, African Trypanosomiasis, Bubo, Dracunculiasis, elephantiasis, Elephantiasis due to filaria , filariasis, Handigodu Syndrome, erysipelas
Musculoskeletal / Ortho	Baker's cyst , Bursitis, Compartment syndrome, Compartment syndrome, Ewings sarcoma, Fuchs' dystrophy, Ganglion cyst, Giant cell tumor of bone, Iliotibial band syndrome, Infantile cortical hyperostosis, Kohler disease, Meniscal cyst, Myorrhexis , Osteoblastoma, Osteochondroma, Osteochondrosis, Osteosarcoma, Palindromic rheumatism, Pigmented villonodular synovitis, Psoriatic arthritis, Sudeck's atrophy , Synovial osteochondromatosis, Synovial sarcoma, Water on knee
Neurologic	No underlying causes
Nutritional / Metabolic	Beriberi, Beriberi Heart Disease, Malnutrition , Obesity hypoventilation syndrome
Obstetric/Gynecologic	Pre-eclampsia, edema proteinuria hypertension (EPH) gestosis, Pregnancy, Premenstrual
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	Cladribine (patient information), Atenolol (patient information), Bisoprolol (patient information), Cyclosporine (patient information), Ganciclovir (patient information), Metoprolol, Nadolol (patient information), Nifedipine (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Propylthiouracil (patient information)
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	Congenital nephrotic syndrome, glomerulonephritis, Lupus nephritis, Nephrotic Syndrome , Renal failure
Rheum / Immune / Allergy	Allergic Reaction, Allergy, Bee sting, Omenn syndrome, Reiter's Disease:Patient Information, Gout, Diabetic nephropathy, Hypoalbuminemia
Sexual	No underlying causes
Trauma	Local trauma , Posttraumatic
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	After radiation therapy , Benign tumor, cancer, Chemotherapy, hyperhydration, Insect bite and stings, Neoplastic , Orthostatic , Palmar plantar erythrodysesthesia, Postoperative , Tumor compression , Tumor in the area of the hypogastrium , Hernia, Angioneurotic edema , idiopathic edema, ishemic leg edemas, Secondary lymphatic blockage , Hypoalbuminemia

Alphabetical order

(In alphabetical order)

Abacavir Acebutolol (patient information) Acitretin (patient information) Acyclovir (patient information) Adalimumab Injection (patient information) Adderall Adenitis African Trypanosomiasis After radiation therapy Albuterol (patient information) Alfuzosin (patient information) Aliskiren Aliskiren (patient information) Aliskiren (patient information) Alitretinoin (patient information) Allergic Reaction Allergy Amantadine (patient information) Amiodarone Amlodipine (patient information) Amlodipine and Benazepril (patientinformation) Anagrelide (patient information) Anastrozole (patient information) Angioneurotic edema Aripiprazole (patient information) Arteriovenous Fistula Ascites Asparaginase (patient information) Atenolol (patient information) Atorvastatin (patient information) Azithromycin Baker's cyst Bee sting Benazepril (patient information) Benign tumor Bepridil (patient information) Beriberi Beriberi Heart Disease Bicalutamide (patient information) Bisoprolol (patient information) Bortezomib (patient information) Bubo Bubonic plague Bursitis cancer Candesartan (patient information) Capecitabine (patient information) Carboplatin (patient information) Cardiomyopathy Carmustine (patient information) Carvedilol (patient information) Caspofungin Cellulitis Chemotherapy Chondroitin sulfate Chronic Venous insufficiency Cidofovir Injection (patient information) Cilostazol (patient information) Ciprofloxacin Cladribine (patient information) Clarithromycin Clopidogrel (patient information) Compartment syndrome Compartment syndrome Congenital nephrotic syndrome Constrictive pericarditis Cor pulmonale Cyanocobalamin Injection (patient information) Cyclosporine (patient information) Cytomegalovirus Immune Globulin Intravenous Injection (patient information) Danazol (patient information) Deep Vein Thrombosis Deferasirox (patient information) Dexamethasone Oral (patient information) Diabetes mellitus Diabetic nephropathy Diclofenac and Misoprostol (patient information) Didanosine (patient information) Diethylpropion (patient information) Diflunisal Digoxin Oral (patient information) Diltiazem (patient information) Diphenoxylate and Atropine (patient information) Disopyramide (patient information) Doxazosin (patient information) Dracunculiasis edema proteinuria hypertension (EPH) gestosis elephantiasis Elephantiasis due to filaria Enalapril (patient information) Enalapril and Felodipine (patient information) Enalapril and Hydrochlorothiazide (patient information) Eprosartan (patient information) erysipelas Erythema nodosum Erythromelalgia Esomeprazole (patient information) Eszopiclone (patient information) Etanercept Injection (patient information) Etidronate (patient information) Etodolac (patient information) Ewings sarcoma Exenatide Injection (patient information) exudative enteropathy Ezetimibe (patient information) Famotidine (patient information) Felodipine (patient information) Fenoprofen (patient information) Fexofenadine (patient information) Fexofenadine and Pseudoephedrine (patient information) filariasis Fluconazole (patient information)

Fluorouracil (patient information) Flutamide (patient information) Fluticasone and Salmeterol Oral Inhalation (patient information) Fluticasone Oral Inhalation (patient information) Fluvastatin (patient information) Formoterol (patient information) Fosinopril (patient information) Fuchs' dystrophy Gabapentin Ganciclovir (patient information) Ganglion cyst Gatifloxacin (patient information) Gefitinib (patient information) Gemcitabine Hydrochloride (patient information) Giant cell tumor of bone Glatiramer Injection (patient information) glomerulonephritis Gout Graves' Disease Handigodu Syndrome heat hereditary lymphedema Hernia Histrelin Injection (patient information) Hydrocortisone Injection (patient information) Hydrocortisone Oral (patient information) Hydrocortisone, Neomycin, and Polymyxin (patient information) Hydroxyurea (patient information) hyperaldosteronism hyperhydration hyperthyroidism Hypertrophic osteopathy Hypoalbuminemia hypothyroidism idiopathic edema Iliotibial band syndrome Imatinib (patient information) Imiglucerase Injection (patient information) Indomethacin (patient information) Infantile cortical hyperostosis Infliximab Injection (patient information) Insect bite and stings Insulin Glulisine (rDNA origin) Injection (patient information) Interferon Beta-1b Injection (patient information) Interferon Gamma-1b Injection (patient information) Ipratropium and Albuterol Inhalation (patient information) Ipratropium Oral Inhalation (patient information) Irbesartan (patient information) Ischemia ishemic leg edemas Isradipine (patient information) Kohler disease Kawasaki disease Kawasaki syndrome Labetalol Oral (patient information) Lamotrigine (patient information) Lansoprazole/clarithromycin/amoxicillin (patient information) left ventricular failure Letrozole (patient information) Leuprolide (patient information) Levocarnitine Injection (patient information) Levodopa and Carbidopa (patient information) Levofloxacin Injection (patient information) Levofloxacin Oral (patient information) Lisinopril (patient information) Lisinopril and Hydrochlorothiazide (patient information) Lithium (patient information) Liver disease with synthesis disorder or portal vein stasis Local trauma Lomefloxacin (patient information) Loratadine (patient information) Losartan (patient information) Losartan and Hydrochlorothiazide (patient information) Lovastatin (patient information) Lupus nephritis Lymphedema Malabsorption Malnutrition May-Thurner syndrome Meclofenamate (patient information) Medroxyprogesterone (patient information) Mefenamic acid Meniscal cyst Mesalamine (patient information) Metoclopramide Hydrochloride Injection (patient information) Metoprolol Mitomycin (patient information) Mitral Stenosis Modafinil (patient information) Moexipril (patient information) Mycophenolate (patient information) Myorrhexis Myxedema Nabumetone (patient information) Nadolol (patient information) Natalizumab injection (patient information) Neoplastic Nephrotic Syndrome Nevirapine (patient information) Nicardipine (patient information) Nifedipine (patient information) Nisoldipine (patient information) Norethindrone (patient information) Norfloxacin (patient information) Obesity hypoventilation syndrome Olanzapine (patient information) Olmesartan (patient information) Omenn syndrome Omeprazole (patient information) Ondansetron (patient information) Orthostatic Osteoblastoma

Osteochondroma Osteochondrosis Osteosarcoma Oxandrolone Oxaprozin Oxcarbazepine (patient information) Oxiconazole (patient information) Oxybutynin (patient information) Oxycodone and aspirin (patient information) Palifermin (patient information) Palindromic rheumatism Palmar plantar erythrodysesthesia Pamidronate injection (patient information) Pancrelipase Pegaspargase (patient information) Peginterferon alfa-2a (patient information) Peginterferon alfa-2b (patient information) Perindopril (patient information) Pernicious anemia Phenazopyridine (patient information) Phenelzine (patient information) Phentermine (patient information) Phenytoin oral (patient information) Phlebitis Phlebothrombosis Phlegmasia cerulea dolens Pigmented villonodular synovitis Pimecrolimus topical (patient information) Pindolol (patient information) Piroxicam (patient information) Posaconazole (patient information) Postischemic Postoperative Post-thrombotic syndrome Posttraumatic Pramipexole (patient information) Pramoxine (patient information) Pravastatin (patient information) Prednisolone Prednisone Pre-eclampsia Pregabalin (patient information) Pregnancy Premenstrual Propranolol Oral (patient information) Propylthiouracil (patient information) Protein-Losing Enteropathy Psoriatic arthritis Quinapril (patient information) Raloxifene Ramipril Reiter's Disease:Patient Information Renal failure Ribavirin (patient information) Risedronate (patient information) Ritonavir (patient information) Ropinirole (patient information) Rosuvastatin (patient information) Salsalate (patient information) Sargramostim injection (patient information) Sebaceous cyst Secondary lymphatic blockage Sibutramine (patient information) Simvastatin (patient information) Sirolimus (patient information) Sodium bicarbonate (patient information) Solifenacin (patient information) Sotalol (patient information) Sudeck's atrophy Sulfinpyrazone (patient information) Sulindac (patient information) Sunitinib (patient information) Synovial osteochondromatosis Synovial sarcoma Systemic vasculitis Tacrolimus topical (patient information) Tamoxifen (patient information) Tamsulosin (patient information) Telithromycin (patient information) Telmisartan (patient information) Temozolomide (patient information) Terazosin (patient information) Testosterone Buccal (patient information) Testosterone Topical (patient information) Thioguanine (patient information) Thrombophlebitis Thrombosis in the vena cava Tiludronate (patient information) Timolol Oral (patient information) Tinidazole (patient information) Tolmetin Trandolapril (patient information) Tranylcypromine (patient information) Trazodone (patient information) Triamcinolone Oral (patient information) Triamcinolone Topical (patient information) Tumor compression Tumor in the area of the hypogastrium Turner's Syndrome Uncompensated hypertension Valganciclovir (patient information) Valsartan (patient information) Vardenafil (patient information) Varicosis Venous insufficiency Verapamil Verapamil and Trandolapril (patient information) Voriconazole (patient information) Vorinostat (patient information) Water on knee Zanamivir Inhalation (patient information) Zoledronic Acid Injection (patient information)