Differentiating Diabetes insipidus from other diseases: Difference between revisions
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**Acquired | **Acquired | ||
***[[Trauma]] ([[surgery]], deceleration injury) | ***[[Trauma]] ([[surgery]], deceleration injury) | ||
***[[Vascular]] ([[cerebral hemorrhage]], [[infarction]], [[anterior communicating artery aneurysm]] or [[ligation]], intra-hypothalamic hemorrhage) | ***[[Vascular]] ([[cerebral hemorrhage]], [[infarction]], [[anterior communicating artery aneurysm]] or [[ligation]], intra-hypothalamic [[hemorrhage]]) | ||
***[[Neoplastic]] ([[craniopharyngioma]], [[meningioma]], [[germinoma]], [[pituitary tumor]] or [[Metastasis|metastases]]) | ***[[Neoplastic]] ([[craniopharyngioma]], [[meningioma]], [[germinoma]], [[pituitary tumor]] or [[Metastasis|metastases]]) | ||
***[[Granulomatous]] ([[histiocytosis]], [[sarcoidosis]]) | ***[[Granulomatous]] ([[histiocytosis]], [[sarcoidosis]]) | ||
***[[Infectious]] ([[meningitis]], [[encephalitis]]) | ***[[Infectious]] ([[meningitis]], [[encephalitis]]) | ||
***[[Inflammatory]]/[[autoimmune]] (lymphocytic infundibuloneurohypophysitis) | ***[[Inflammatory]]/[[autoimmune]] ([[lymphocytic]] infundibuloneurohypophysitis) | ||
***[[Drug]]/[[toxin]]-induced ([[ethanol]], [[diphenylhydantoin]], snake venom) | ***[[Drug]]/[[toxin]]-induced ([[ethanol]], [[diphenylhydantoin]], snake venom) | ||
***Other disorders ([[hydrocephalus]], ventricular/suprasellar cyst, [[trauma]], degenerative diseases) | ***Other disorders ([[hydrocephalus]], ventricular/[[suprasellar]] cyst, [[trauma]], [[degenerative diseases]]) | ||
***[[Idiopathic]] | ***[[Idiopathic]] | ||
**[[Congenital disorder|Congenital]] | **[[Congenital disorder|Congenital]] | ||
***Congenital malformations | ***[[Congenital malformations]] | ||
****[[Autosomal dominant|Autosomal dominant:]] AVP-neurophysin gene mutations | ****[[Autosomal dominant|Autosomal dominant:]] AVP-neurophysin gene mutations | ||
****[[Autosomal recessive]] :<ref name="pmid10369876">{{cite journal| author=Willcutts MD, Felner E, White PC| title=Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin. | journal=Hum Mol Genet | year= 1999 | volume= 8 | issue= 7 | pages= 1303-7 | pmid=10369876 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10369876 }} </ref><ref name="pmid19897608">{{cite journal| author=Abu Libdeh A, Levy-Khademi F, Abdulhadi-Atwan M, Bosin E, Korner M, White PC et al.| title=Autosomal recessive familial neurohypophyseal diabetes insipidus: onset in early infancy. | journal=Eur J Endocrinol | year= 2010 | volume= 162 | issue= 2 | pages= 221-6 | pmid=19897608 | doi=10.1530/EJE-09-0772 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19897608 }} </ref> [[Wolfram syndrome|Wolfram Syndrome]] (DIDMOAD) <ref name="pmid9350817">{{cite journal| author=Barrett TG, Bundey SE| title=Wolfram (DIDMOAD) syndrome. | journal=J Med Genet | year= 1997 | volume= 34 | issue= 10 | pages= 838-41 | pmid=9350817 | doi= | pmc=1051091 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9350817 }} </ref> | ****[[Autosomal recessive]] :<ref name="pmid10369876">{{cite journal| author=Willcutts MD, Felner E, White PC| title=Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin. | journal=Hum Mol Genet | year= 1999 | volume= 8 | issue= 7 | pages= 1303-7 | pmid=10369876 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10369876 }} </ref><ref name="pmid19897608">{{cite journal| author=Abu Libdeh A, Levy-Khademi F, Abdulhadi-Atwan M, Bosin E, Korner M, White PC et al.| title=Autosomal recessive familial neurohypophyseal diabetes insipidus: onset in early infancy. | journal=Eur J Endocrinol | year= 2010 | volume= 162 | issue= 2 | pages= 221-6 | pmid=19897608 | doi=10.1530/EJE-09-0772 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19897608 }} </ref> [[Wolfram syndrome|Wolfram Syndrome]] (DIDMOAD) <ref name="pmid9350817">{{cite journal| author=Barrett TG, Bundey SE| title=Wolfram (DIDMOAD) syndrome. | journal=J Med Genet | year= 1997 | volume= 34 | issue= 10 | pages= 838-41 | pmid=9350817 | doi= | pmc=1051091 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9350817 }} </ref> | ||
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***[[Hypercalcemia]], [[hypokalemia]] | ***[[Hypercalcemia]], [[hypokalemia]] | ||
***Infiltrating lesions ([[sarcoidosis]], [[amyloidosis]], [[multiple myeloma]], [[Sjögren's syndrome|Sjogren's disease]]) | ***Infiltrating lesions ([[sarcoidosis]], [[amyloidosis]], [[multiple myeloma]], [[Sjögren's syndrome|Sjogren's disease]]) | ||
***Vascular ([[Sickle-cell disease|sickle cell disease]]) | ***[[Vascular]] ([[Sickle-cell disease|sickle cell disease]]) | ||
**Congenital | **Congenital | ||
***[[X-linked recessive]] (OMIM 304800): AVP V2 receptor gene mutations | ***[[X-linked recessive]] (OMIM 304800): AVP V2 receptor gene mutations | ||
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* Scaly, [[erythematous]] scalp patches | * Scaly, [[erythematous]] scalp patches | ||
* [[Lung]] involvement | * [[Lung]] involvement | ||
* GI bleeding | * [[GI bleeding]] | ||
* [[Lymphadenopathy|Lymph node enlargement]]<ref name="pmid1340034">{{cite journal| author=Ghosh KN, Bhattacharya A| title=Gonotrophic nature of Phlebotomus argentipes (Diptera: Psychodidae) in the laboratory. | journal=Rev Inst Med Trop Sao Paulo | year= 1992 | volume= 34 | issue= 2 | pages= 181-2 | pmid=1340034 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1340034 }} </ref> | * [[Lymphadenopathy|Lymph node enlargement]]<ref name="pmid1340034">{{cite journal| author=Ghosh KN, Bhattacharya A| title=Gonotrophic nature of Phlebotomus argentipes (Diptera: Psychodidae) in the laboratory. | journal=Rev Inst Med Trop Sao Paulo | year= 1992 | volume= 34 | issue= 2 | pages= 181-2 | pmid=1340034 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1340034 }} </ref> | ||
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| | | | ||
* [[Headache]] | * [[Headache]] | ||
* Endocrine dysfunction | * [[Endocrine disorders|Endocrine dysfunction]] | ||
** [[Diabetes insipidus]] | ** [[Diabetes insipidus]] | ||
** [[Hypothyroidism]] | ** [[Hypothyroidism]] | ||
** [[Adrenal failure]] | ** [[Adrenal failure]] | ||
** [[Diabetes insipidus]] (eg, excessive fluid intake and urination) | ** [[Diabetes insipidus]] (eg, excessive fluid intake and urination) | ||
** Growth failure and delayed puberty | ** Growth failure and [[delayed puberty]] | ||
| | | | ||
* [[Suprasellar]] calcified cyst on [[MRI]] | * [[Suprasellar]] calcified cyst on [[MRI]] | ||
| Line 187: | Line 187: | ||
* History of [[psychiatric disorders]] | * History of [[psychiatric disorders]] | ||
|- | |- | ||
|Pregnancy | |[[Pregnancy]] | ||
| | | | ||
|Gestational diabetes insipidus | |Gestational diabetes insipidus | ||
| | | | ||
* [[Polyuria]] | * [[Polyuria]] | ||
* [[Polydipsia]] | * [[Polydipsia]] | ||
* [[Nocturia]] | * [[Nocturia]] | ||
| Line 203: | Line 203: | ||
| | | | ||
| | | | ||
* [[Polyuria]] | * [[Polyuria]] | ||
* [[Polydipsia]] | * [[Polydipsia]] | ||
* [[Nocturia]] | * [[Nocturia]] | ||
Revision as of 15:34, 1 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diabetes insipidus must be differentiated from other diseases that cause polyuria which is defined as a urine output exceeding 3 L/day in adults and 2 L/m2 in children, increased frequency or nocturia and polydipsia. It is important to know that levels of hypo or hypernatremia is not sufficient to describe the underlying cause of diabetes insipidus.
Differentiating Diabetes insipidus from other Diseases
Differentiating diabetes insipidus based on the type of diabetes insipidus caused
- Central diabetes insipidus
- Acquired
- Trauma (surgery, deceleration injury)
- Vascular (cerebral hemorrhage, infarction, anterior communicating artery aneurysm or ligation, intra-hypothalamic hemorrhage)
- Neoplastic (craniopharyngioma, meningioma, germinoma, pituitary tumor or metastases)
- Granulomatous (histiocytosis, sarcoidosis)
- Infectious (meningitis, encephalitis)
- Inflammatory/autoimmune (lymphocytic infundibuloneurohypophysitis)
- Drug/toxin-induced (ethanol, diphenylhydantoin, snake venom)
- Other disorders (hydrocephalus, ventricular/suprasellar cyst, trauma, degenerative diseases)
- Idiopathic
- Congenital
- Congenital malformations
- Autosomal dominant: AVP-neurophysin gene mutations
- Autosomal recessive :[1][2] Wolfram Syndrome (DIDMOAD) [3]
- X-linked recessive
- Idiopathic
- Congenital malformations
- Acquired
- Nephrogenic diabetes insipidus
- Acquired
- Drug-induced (demeclocycline, lithium, cisplatin, methoxyflurane, etc.)
- Hypercalcemia, hypokalemia
- Infiltrating lesions (sarcoidosis, amyloidosis, multiple myeloma, Sjogren's disease)
- Vascular (sickle cell disease)
- Congenital
- X-linked recessive (OMIM 304800): AVP V2 receptor gene mutations
- Autosomal recessive: AQP2 water channel gene mutations
- Acquired
- Primary polydipsia
- Psychogenic
- Dipsogenic (downward resetting of thirst threshold)
- Gestational Diabetes insipidus
- Diabetes meliitus
| Type of DI | Subclass | Disease | Defining signs and symptoms | Lab/Imaging findings |
|---|---|---|---|---|
| Central | Acquired | Histiocytosis |
|
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| Craniopharyngioma |
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| Sarcoidosis |
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| Congenital | Hydrocephalus |
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Dilated ventricles on CT and MRI | |
| Wolfram Syndrome (DIDMOAD) |
| |||
| Nephrogenic | Acquired | Drug-induced (demeclocycline, lithium) |
| |
| Hypercalcemia |
| |||
| Hypokalemia |
| |||
| Multiple myeloma |
|
| ||
| Sickle cell disease |
|
| ||
| Primary polydipsia | Psychogenic |
| ||
| Pregnancy | Gestational diabetes insipidus |
| ||
| Diabetes mellitus |
| |||
References
- ↑ Willcutts MD, Felner E, White PC (1999). "Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin". Hum Mol Genet. 8 (7): 1303–7. PMID 10369876.
- ↑ Abu Libdeh A, Levy-Khademi F, Abdulhadi-Atwan M, Bosin E, Korner M, White PC; et al. (2010). "Autosomal recessive familial neurohypophyseal diabetes insipidus: onset in early infancy". Eur J Endocrinol. 162 (2): 221–6. doi:10.1530/EJE-09-0772. PMID 19897608.
- ↑ Barrett TG, Bundey SE (1997). "Wolfram (DIDMOAD) syndrome". J Med Genet. 34 (10): 838–41. PMC 1051091. PMID 9350817.
- ↑ Ghosh KN, Bhattacharya A (1992). "Gonotrophic nature of Phlebotomus argentipes (Diptera: Psychodidae) in the laboratory". Rev Inst Med Trop Sao Paulo. 34 (2): 181–2. PMID 1340034.