Anileridine: Difference between revisions

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Anileridine
Clinical data
AHFS/Drugs.com	Monograph
Routes of; administration	Tablets, injection
ATC code	N01AH05 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled) ; CA: ℞-only ; US: Schedule II ;
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
	IUPAC name Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	144-14-9 ;
PubChem CID	8944;
DrugBank	DB00913 ;
ChemSpider	8600 ;
UNII	71Q1A3O279;
KEGG	D02941 ;
ChEBI	CHEBI:61203 ;
ChEMBL	ChEMBL1201347 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H28N2O2
Molar mass	352.47 g/mol
3D model (JSmol)	Interactive image;
Melting point	83 °C (181.4 °F)
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3;
	InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 ; Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 18:46, 8 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s. It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.^[1]

Administration

As tablets or injection.^[2]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.^[3] It is mostly metabolized by the liver.

References

↑ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
↑ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
↑ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

Template:General anesthetics

[1] "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.

[2] "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.

[3] "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

[1]

[2]

[3]

@@ Line 56: / Line 56: @@
 }}
 __NOTOC__
 {{SI}}
 {{CMG}}
 ==Overview==
-'''Anileridine''' (trade name: '''Leritine''') is a synthetic [[analgesic]] drug and is a member of the [[piperidine]] class of analgesic agents developed by Merck & Co. in the 1950s.<ref>{{US Patent|2897204}}</ref> It differs from [[pethidine]] (meperidine) in that the ''N''-methyl group of meperidine is replaced by an ''N''-aminophenethyl group, which increases its analgesic activity.
+'''Anileridine''' (trade name: '''Leritine''') is a synthetic [[analgesic]] drug and is a member of the [[piperidine]] class of analgesic agents developed by Merck & Co. in the 1950s. It differs from [[pethidine]] (meperidine) in that the ''N''-methyl group of meperidine is replaced by an ''N''-aminophenethyl group, which increases its analgesic activity.
 Anileridine is no longer manufactured in the US or Canada.<ref>{{Cite web |last= |first= |title=Discontinued Prescription Drug Products |publisher=Canadian Pharmacists' Association |date= |url=http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm |accessdate=28 July 2008}}</ref>
 ==Administration==
-As [[Tablet (pharmacy)|tablets]] or [[Injection (medicine)|injection]].<ref>{{Cite web |last= |first= |title=Pharmaceutical Information - LERITINE |publisher=RxMed |date= |url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html |accessdate=16 June 2010 }}</ref>
+As tablets or [[Injection (medicine)|injection]].<ref>{{Cite web |last= |first= |title=Pharmaceutical Information - LERITINE |publisher=RxMed |date= |url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html |accessdate=16 June 2010 }}</ref>
 ==Pharmacokinetics==
@@ Line 77: / Line 74: @@
 {{Analgesics}}
 {{General anesthetics}}
-{{Opioidergics}}
 [[Category:Piperidines]]
 [[Category:Synthetic opioids]]
-[[Category:General anesthetics]]
-[[Category:Anilines]]
-[[Category:Ethyl esters]]
 [[Category:Mu-opioid agonists]]
 [[Category:Analgesics]]

v t e Analgesic products (N02A, N02B)
Opioids See also: Opioids template	Alphaprodine · Anileridine · Buprenorphine · Butorphanol · Codeine · Dextromoramide · Dextropropoxyphene · Dezocine · Desomorphine · Diamorphine · Dihydrocodeine · Dihydromorphine · Fentanyl · Hydrocodone · Hydromorphone · Ketobemidone · Levorphanol · Meptazinol · Methadone · Morphine · Nalbuphine · Nicomorphine · Opium · Oxycodone · Oxymorphone · Pethidine · Pentazocine · Pethidine · Piminodine · Piritramide · Tilidine · Tramadol · Tapentadol
Salicylic acid and derivatives	Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Magnesium Salicylate · Salicin · Salicylamide · Salsalate · See also: NSAIDs
Pyrazolones	Ampyrone/Aminophenazone · Metamizole · Phenazone
Cannabinoids	Cannabis · Tetrahydrocannabinol · AM404
Anilides	Paracetamol (acetaminophen) · Phenacetin · Propacetamol
Non-Salicylate Non-Steroidal Anti-Inflammatories See also: NSAIDs template	Template:Navbox subgroup
Atypical, Adjunct & Miscellaneous	Bicifadine · Clonidine · Cyclobenzaprine · Duloxetine · Flupirtine · Gabapentin · Nefopam · Orphenadrine · Trazadone · Ziconotide

Clinical data

AHFS/Drugs.com	Monograph
Routes of administration	Tablets, injection
ATC code	N01AH05 (WHO)
Legal status
Legal status	AU: S8 (Controlled) CA: ℞-only US: Schedule II
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
IUPAC name Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
CAS Number	144-14-9^Y
PubChem CID	8944
DrugBank	DB00913^Y
ChemSpider	8600^Y
UNII	71Q1A3O279
KEGG	D02941^Y
ChEBI	CHEBI:61203^Y
ChEMBL	ChEMBL1201347^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₂H₂₈N₂O₂
Molar mass	352.47 g/mol
3D model (JSmol)	Interactive image
Melting point	83 °C (181.4 °F)
SMILES O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3
InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3^Y Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)