Pulmonary embolism laboratory findings: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 7: Line 7:


==Laboratory Findings==
==Laboratory Findings==
Laboratory studies that are frequently ordered in the assessment of pulmonary embolism include the following:
===D-dimer Test===
 
*[[Pulmonary embolism arterial blood gas analysis]]
*Plasma [[D-dimer]]
*Plasma [[D-dimer]]
**Plasma D-dimer>500 ng/ml, PE present (Found to be 97% sensitive and 45% specific)
**Plasma D-dimer>500 ng/ml, PE present (Found to be 97% sensitive and 45% specific)
**Plasma D-dimer<500 excludes PE (Have a high negative predictive value)
**Plasma D-dimer<500 excludes PE (Have a high negative predictive value)
===Routine Blood Tests===
*[[Pulmonary embolism arterial blood gas analysis]]
*In patients with acute pulmonary embolism, routine laboratory findings are non-specific and include:
:*[[Leukocytosis]]
:*[[erythrocyte sedimentation rate|Elevated ESR]] with an elevated [[LDH|serum LDH]] and [[transaminases|serum transaminase]] (especially [[Aspartate transaminase|AST or SGOT]])
:*[[bilirubin|Serum bilirubin]] levels are found to be within normal limits
===Workup for Hypercoagulability===
*Workup for [[hypercoagulation]]: which include
*Workup for [[hypercoagulation]]: which include
**Activated [[protein C]] resistance  
**Activated [[protein C]] resistance  
Line 22: Line 29:
**[[Anticardiolipin antibodies]]
**[[Anticardiolipin antibodies]]
**Plasma [[homocysteine]] values
**Plasma [[homocysteine]] values
*In patients with acute pulmonary embolism, routine laboratory findings are non-specific and include:
:*[[Leukocytosis]]
:*[[erythrocyte sedimentation rate|Elevated ESR]] with an elevated [[LDH|serum LDH]] and [[transaminases|serum transaminase]] (especially [[Aspartate transaminase|AST or SGOT]])
:*[[bilirubin|Serum bilirubin]] levels are found to be within normal limits


==References==
==References==

Revision as of 15:39, 18 June 2014

Pulmonary Embolism Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pulmonary Embolism from other Diseases

Epidemiology and Demographics

Risk Factors

Triggers

Natural History, Complications and Prognosis

Diagnosis

Diagnostic criteria

Assessment of Clinical Probability and Risk Scores

Pulmonary Embolism Assessment of Probability of Subsequent VTE and Risk Scores

History and Symptoms

Physical Examination

Laboratory Findings

Arterial Blood Gas Analysis

D-dimer

Biomarkers

Electrocardiogram

Chest X Ray

Ventilation/Perfusion Scan

Echocardiography

Compression Ultrasonography

CT

MRI

Treatment

Treatment approach

Medical Therapy

IVC Filter

Pulmonary Embolectomy

Pulmonary Thromboendarterectomy

Discharge Care and Long Term Treatment

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Follow-Up

Support group

Special Scenario

Pregnancy

Cancer

Trials

Landmark Trials

Case Studies

Case #1

Pulmonary embolism laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pulmonary embolism laboratory findings

CDC on Pulmonary embolism laboratory findings

Pulmonary embolism laboratory findings in the news

Blogs on Pulmonary embolism laboratory findings

Directions to Hospitals Treating Pulmonary embolism laboratory findings

Risk calculators and risk factors for Pulmonary embolism laboratory findings

Editor(s)-In-Chief: C. Michael Gibson, M.S., M.D. [1], The APEX Trial Investigators; Associate Editor(s)-in-Chief:

Overview

The results of routine laboratory tests including arterial blood gas analysis are non-specific in making the diagnosis of pulmonary embolism. These laboratory studies can be obtained to rule-out other cause of chest discomfort and tachypnea. In patients with acute pulmonary embolism, non-specific lab findings include: leukocytosis, elevated ESR with an elevated serum LDH and serum transaminase (especially AST or SGOT). A negative D-dimer in a patient with low to intermediate probability of pulmonary embolism strongly suggests pulmonary embolism is not present.

Laboratory Findings

D-dimer Test

  • Plasma D-dimer
    • Plasma D-dimer>500 ng/ml, PE present (Found to be 97% sensitive and 45% specific)
    • Plasma D-dimer<500 excludes PE (Have a high negative predictive value)

Routine Blood Tests

Workup for Hypercoagulability

References

Template:WH Template:WS