Irritable bowel syndrome causes: Difference between revisions
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*IBS is caused by a mutation of type V (alpha subunit) of ''SCN5A''-encoded voltage gated sodium channel gene. Other genes such as [[Tumour necrosis factor|tumor necrosis factor]] alpha (TNFα) and genes coding for superfamily member 15 (''TNFSF15'') are also involved. | *IBS is caused by a mutation of type V (alpha subunit) of ''SCN5A''-encoded voltage gated sodium channel gene. Other genes such as [[Tumour necrosis factor|tumor necrosis factor]] alpha (TNFα) and genes coding for superfamily member 15 (''TNFSF15'') are also involved. | ||
*SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation and epithelial barriers. | *SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation and epithelial barriers. | ||
*Genes involved in the regulation of hepatic [[bile acid]] synthesis such as a functional Klothoβ gene variant are mutated in IBS patients. | *Genes involved in the regulation of [[Liver|hepatic]] [[bile acid]] synthesis such as a functional Klothoβ gene variant are mutated in IBS patients. | ||
*Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to [[neuropeptide]] hormone function and oxidative stress. | *Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to [[neuropeptide]] hormone function and oxidative stress. | ||
Revision as of 20:54, 25 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The most common cause of IBS is emotional disturbances, stress, adverse early life events, history of Inflammatory bowel disease, acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes.
Causes
Common Causes
IBS may be caused by:
- Emotional disturbance or stress
- Adverse early life events
- Anxiety, depression
- History of acute GI infections e.g. Salmonella infection, Giardiasis
- Antibiotic use causing alteration of gut microflora
- History of gastrointestinal disorders like IBD
- Immune causes: history of IBD, Celiac disease, microscopic colitis
Less Common Causes
Less common causes of disease name include:
- Genetics
- Hormonal changes
Genetic Causes
- IBS is caused by a mutation of type V (alpha subunit) of SCN5A-encoded voltage gated sodium channel gene. Other genes such as tumor necrosis factor alpha (TNFα) and genes coding for superfamily member 15 (TNFSF15) are also involved.
- SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation and epithelial barriers.
- Genes involved in the regulation of hepatic bile acid synthesis such as a functional Klothoβ gene variant are mutated in IBS patients.
- Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to neuropeptide hormone function and oxidative stress.